Gene: SPATS2L

26010
DNAPTP6|SGNP
spermatogenesis associated serine rich 2 like
protein-coding
2q33.1
Ensembl:ENSG00000196141 MIM:613817 Vega:OTTHUMG00000154589 UniprotKB:Q9NUQ6
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.669e-1 (AD)  6.763e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2028201chr2:200438287 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCT20.873
MED80.869
CCT40.869
PRMT50.866
TOP10.864
SRXN10.864
AKIRIN20.863
PSMF10.862
POLR2C0.861
LRRC590.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.664
OR4F29-0.62
CTNNA3-0.33
C5orf64-0.309
VNN3-0.275
TRPV5-0.27
SH2D1A-0.267
TNFRSF13B-0.263
SLCO1A2-0.256
P2RY14-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SPATS2L mRNA"19114083
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SPATS2L mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SPATS2L mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATS2L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATS2L mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SPATS2L mRNA21420995|2669055
D020106AcrylamideAcrylamide results in decreased expression of SPATS2L mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SPATS2L gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SPATS2L mRNA24449571
D004958EstradiolEstradiol results in increased expression of SPATS2L mRNA18556351|2118537
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SPATS2L mRNA18556351
C006780bisphenol Abisphenol A affects the expression of SPATS2L mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SPATS2L promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of SPATS2L mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of SPATS2L mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of SPATS2L mRNA24386269
D003042CocaineCocaine results in increased expression of SPATS2L mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of SPATS2L mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SPATS2L mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SPATS2L mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SPATS2L mRNA21266533
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of SPATS2L mRNA"27840820
D004237DiuronDiuron results in decreased expression of SPATS2L mRNA25152437
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SPATS2L mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of SPATS2L mRNA23649840
D019833GenisteinGenistein results in increased expression of SPATS2L protein24552547
D007854LeadLead affects the splicing of SPATS2L mRNA28903495
C045463leflunomideleflunomide results in increased expression of SPATS2L mRNA28988120
D008727MethotrexateMethotrexate results in increased expression of SPATS2L mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SPATS2L mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of SPATS2L mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SPATS2L mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of SPATS2L mRNA22124623
C025589ochratoxin Aochratoxin A results in increased expression of SPATS2L mRNA22124623
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SPATS2L mRNA25729387
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SPATS2L mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of SPATS2L mRNA28655636
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPATS2L mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SPATS2L mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPATS2L mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPATS2L mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SPATS2L mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SPATS2L mRNA18556351
D011441PropylthiouracilPropylthiouracil results in increased expression of SPATS2L mRNA24780913
C010327salinomycinsalinomycin results in decreased expression of SPATS2L mRNA19682730
C541923sandostatinLARsandostatinLAR results in increased expression of SPATS2L mRNA17210224
C017947sodium arsenitesodium arsenite affects the localization of SPATS2L protein19005571
C017947sodium arsenitesodium arsenite results in increased expression of SPATS2L mRNA20020861
C017947sodium arseniteSPATS2L protein affects the susceptibility to sodium arsenite19005571
C016104sodium bichromatesodium bichromate results in decreased expression of SPATS2L mRNA17685462
D012999SomanSoman results in decreased expression of SPATS2L mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SPATS2L promoter]19654925
D013806TheophyllineTheophylline results in decreased expression of SPATS2L mRNA18951874
C009495titanium dioxidetitanium dioxide results in increased expression of SPATS2L mRNA23557971
D014050TolueneToluene results in decreased expression of SPATS2L mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SPATS2L mRNA25729387
D019772TopotecanTopotecan results in increased expression of SPATS2L mRNA25729387
D014212TretinoinTretinoin results in increased expression of SPATS2L mRNA21934132|2372400
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SPATS2L mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of SPATS2L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SPATS2L gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SPATS2L mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SPATS2L mRNA28655636
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SPATS2L gene25560391
C025643vinclozolinvinclozolin results in increased expression of SPATS2L mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of SPATS2L mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0032991protein-containing complex-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal