Gene: TENM4

26011
Doc4|ETM5|ODZ4|TNM4|Ten-M4|ten-4
teneurin transmembrane protein 4
protein-coding
11q14.1
Ensembl:ENSG00000149256 MIM:610084 Vega:OTTHUMG00000166770 UniprotKB:Q6N022
NG_051803.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.081e-1 (AD)  1.698e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs630970chr11:79013169 (GRCh38.p7)A>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGSM10.897
UBE2O0.896
HERC10.887
TLN20.884
POLR3A0.884
ATG16L10.884
RYR20.883
BTRC0.882
FAM135B0.881
UQCC10.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.557
COPZ2-0.515
YES1-0.504
HEY2-0.488
KLRB1-0.487
MYOM1-0.486
TFPI2-0.476
MBNL3-0.474
MYL3-0.467
KLRF1-0.455

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of TENM4 mRNA"22698814
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of TENM4 mRNA"20713471
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TENM4 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM4 mRNA"27188386
C547126AZM551248AZM551248 results in decreased expression of TENM4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of TENM4 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TENM4 mRNA20713471|2222880
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TENM4 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TENM4 mRNA]25566086
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of TENM4 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TENM4 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TENM4 mRNA19619570
C006780bisphenol Abisphenol A results in increased expression of TENM4 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in decreased expression of TENM4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TENM4 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of TENM4 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TENM4 mRNA15336504
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TENM420938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TENM4 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TENM4 gene20938992
C031180chrysenechrysene results in increased expression of TENM4 mRNA26377693
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in increased expression of TENM4 mRNA18355967
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TENM4 mRNA20971185
D003300CopperCopper deficiency results in increased expression of TENM4 mRNA26033743
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TENM4 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TENM4 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of TENM4 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of TENM4 mRNA26033743
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of TENM4 mRNA"21785161
C118739entinostatentinostat results in increased expression of TENM4 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TENM4 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TENM420938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TENM4 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TENM4 gene20938992
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of TENM4 mRNA20846436
C069837fullerene C60fullerene C60 results in decreased expression of TENM4 mRNA19167457
C039281furanfuran results in decreased expression of TENM4 mRNA25539665
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TENM4 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of TENM4 mRNA28973697
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TENM420938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TENM4 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TENM4 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TENM4 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TENM4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TENM4 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TENM4 mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TENM4 mRNA26705709
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of TENM4 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of TENM4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TENM4 mRNA25351596
D012834SilverSilver results in decreased expression of TENM4 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of TENM4 gene28589171
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TENM4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TENM4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TENM4 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of TENM4 mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TENM4 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TENM4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TENM4 mRNA23179753|2519280
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TENM4 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TENM4 mRNA23555832
C088658zoledronic acidzoledronic acid results in increased expression of TENM4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042803protein homodimerization activity-IBA21873635  
GO:0042803protein homodimerization activity-ISS-  
GO:0046982protein heterodimerization activity-IBA21873635  
GO:0050839cell adhesion molecule binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001702gastrulation with mouth forming second-IEA-  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0007165signal transduction-IEA-  
GO:0031641regulation of myelination-IMP26188006  
GO:0031643positive regulation of myelination-ISS-  
GO:0032289central nervous system myelin formation-IMP26188006  
GO:0032289central nervous system myelin formation-ISS-  
GO:0048666neuron development-IBA21873635  
GO:0048666neuron development-IMP26188006  
GO:0048714positive regulation of oligodendrocyte differentiation-ISS-  
GO:0060038cardiac muscle cell proliferation-IEA-  
GO:0060912cardiac cell fate specification-IEA-  
GO:0097264self proteolysis-IEA-  
GO:2000543positive regulation of gastrulation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IDA26188006  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal