Gene: LRIG1

26018
LIG-1|LIG1
leucine rich repeats and immunoglobulin like domains 1
protein-coding
3p14.1
Ensembl:ENSG00000144749 MIM:608868 Vega:OTTHUMG00000158727 UniprotKB:Q96JA1
NC_000003.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.981e-1 (AD)  2.797e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11198596chr3:66548117LRIG13.100e-15Smoking27651444
cg06096184chr3:66549732LRIG12.800e-12Smoking27651444
cg06189394chr3:66534050LRIG11.000e-11Smoking27651444
cg24150385chr3:66543263LRIG12.800e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX40.924
SLC1A30.915
AQP40.911
F30.906
SOX90.9
TP53BP20.894
ATP1B20.891
HEPH0.888
BMPR1B0.885
DDR10.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.408
TYRP1-0.398
SERF1B-0.387
DUSP27-0.384
SAMD5-0.384
CALHM1-0.377
ABCC12-0.374
OR4F29-0.374
MYOZ3-0.372
PPEF1-0.372

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LRIG1 mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of LRIG1 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LRIG1 mRNA"19167446
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of LRIG1 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LRIG1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of LRIG1 mRNA"26238291
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRIG1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LRIG1 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of LRIG1 mRNA21757418
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of LRIG1 mRNA28713220
D001151ArsenicArsenic affects the expression of LRIG1 mRNA18414638
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRIG1 mRNA22316170|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRIG1 mRNA"20382639
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRIG1 mRNA28628672
D002922CiguatoxinsCiguatoxins affects the expression of LRIG1 mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of LRIG1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of LRIG1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of LRIG1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of LRIG1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of LRIG1 mRNA19770486
D003561CytarabineCytarabine results in increased expression of LRIG1 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRIG1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of LRIG1 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LRIG1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LRIG1 mRNA27392435
D002945CisplatinLRIG1 protein inhibits the reaction [Cisplatin results in increased phosphorylation of and affects the localization of EGFR protein]21431282
D002945CisplatinLRIG1 protein results in increased susceptibility to Cisplatin21431282
D002945CisplatinCisplatin results in increased expression of LRIG1 mRNA21151649
D002117CalcitriolCalcitriol results in increased expression of LRIG1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LRIG1 mRNA21592394
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRIG1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LRIG1 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of LRIG1 mRNA28329830
D017313FenretinideFenretinide results in decreased expression of LRIG1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRIG1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LRIG1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LRIG1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LRIG1 mRNA27392435
D007854LeadLead affects the expression of LRIG1 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of LRIG1 mRNA22613225
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LRIG1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRIG1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRIG1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LRIG1 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of LRIG1 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of LRIG1 mRNA21195148
C523799MRK 003LRIG1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LRIG1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LRIG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LRIG1 mRNA"25620056
D010100OxygenOxygen deficiency results in increased expression of LRIG1 mRNA24205000
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of LRIG1 mRNA26272509
C016030pantogabpantogab results in decreased expression of LRIG1 mRNA17379144
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LRIG1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of LRIG1 mRNA18445702|2081375
D011374ProgesteroneProgesterone results in increased expression of LRIG1 mRNA20864642
D011441PropylthiouracilPropylthiouracil results in decreased expression of LRIG1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of LRIG1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of LRIG1 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA19059307
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of LRIG1 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LRIG1 mRNA25895662
C533467SM 164LRIG1 protein affects the susceptibility to SM 16422241084
C533467SM 164LRIG1 protein promotes the reaction [SM 164 results in increased expression of TNF mRNA]22241084
C533467SM 164LRIG1 protein promotes the reaction [SM 164 results in increased expression of TNF protein]22241084
C017947sodium arsenitesodium arsenite results in decreased expression of LRIG1 mRNA28713220
D013629TamoxifenTamoxifen affects the expression of LRIG1 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA19059307
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LRIG1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LRIG1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRIG1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinLRIG1 affects the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]28973660
D013749TetrachlorodibenzodioxinLRIG1 affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]28973660
D013749TetrachlorodibenzodioxinLRIG1 results in increased susceptibility to Tetrachlorodibenzodioxin28973660
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRIG1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRIG1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRIG1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRIG1 mRNA18691609
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LRIG1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LRIG1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of LRIG1 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of LRIG1 mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LRIG1 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of LRIG1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of LRIG1 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of LRIG1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of LRIG1 mRNA19101580|2915479
D014635Valproic AcidValproic Acid affects the expression of LRIG1 mRNA17963808
D014638VanadatesVanadates results in increased expression of LRIG1 mRNA22714537
C029297vinylidene chloridevinylidene chloride results in increased expression of LRIG1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of LRIG1 mRNA20044591
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRIG1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of LRIG1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007605sensory perception of sound-IEA-  
GO:0022405hair cycle process-IEA-  
GO:0032474otolith morphogenesis-IEA-  
GO:0060384innervation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-177929Signaling by EGFRTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19334046Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. (2009 Jun)Boelens MCJ Pathol
24998916Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. (2014 Apr 15)Lindstrom AKEur J Histochem
17624990LRIG1 and squamous epithelial uterine cervical cancer: correlation to prognosis, other tumor markers, sex steroid hormones, and smoking. (2008 Mar-Apr)Lindstrom AKInt J Gynecol Cancer
25813475LRIG1 is a prognostic biomarker in non-small cell lung cancer. (2015)Kvarnbrink SActa Oncol