Gene: CYP4X1

260293
CYPIVX1
cytochrome P450 family 4 subfamily X member 1
protein-coding
1p33|1
Ensembl:ENSG00000186377 MIM:614999 Vega:OTTHUMG00000008017 UniprotKB:Q8N118
NG_007966.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.893e-1 (AD)  9.586e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9727862chr1:47015944 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL20.958
SCN2A0.957
MAGEE10.952
SYT40.95
NEGR10.949
MAP7D20.949
GPRASP20.949
REEP10.948
GLRB0.948
ADAM230.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.536
RAI14-0.534
REST-0.525
RAB13-0.517
CSAG1-0.517
WWTR1-0.515
SYDE1-0.511
CNN2-0.508
HEY2-0.503
RNF135-0.497

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP4X1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP4X1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP4X1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP4X1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CYP4X1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYP4X1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYP4X1 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP4X1 mRNA16483693
C015001arsenitearsenite results in increased expression of CYP4X1 mRNA23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP4X1 mRNA20064835|2010694
D004958EstradiolEstradiol results in decreased expression of CYP4X1 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of CYP4X1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of CYP4X1 protein22174045
D002220CarbamazepineCarbamazepine affects the expression of CYP4X1 mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of CYP4X1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CYP4X1 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of CYP4X1 mRNA21198554
D003976DiazinonDiazinon results in decreased methylation of CYP4X1 gene22964155
D002117CalcitriolCalcitriol results in decreased expression of CYP4X1 mRNA27107558
C118739entinostatentinostat results in increased expression of CYP4X1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP4X1 mRNA"27188386
D011345FenofibrateFenofibrate results in increased expression of CYP4X1 mRNA25572481
D005419FlavonoidsFlavonoids results in increased expression of CYP4X1 mRNA18035473
C039281furanfuran results in increased methylation of CYP4X1 gene22079235
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CYP4X1 mRNA17183730
D007854LeadLead affects the expression of CYP4X1 mRNA28903495
C006253pirinixic acidpirinixic acid results in increased expression of CYP4X1 mRNA15797250
D011441PropylthiouracilPropylthiouracil results in increased expression of CYP4X1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CYP4X1 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP4X1 mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYP4X1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP4X1 mRNA28213091
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CYP4X1 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of CYP4X1 mRNA24935251
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CYP4X1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP4X1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of CYP4X1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CYP4X1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CYP4X1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005506iron ion binding-IEA-  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26095139Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)Toselli FXenobiotica