Gene: SUSD5

26032
-
sushi domain containing 5
protein-coding
3p22.3
Ensembl:ENSG00000173705 Vega:OTTHUMG00000155829 UniprotKB:O60279
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.459e-1 (AD)  6.884e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4389431chr3:33201894 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMX40.878
KIF3A0.875
SLC39A100.874
GSK3B0.871
TRIM370.868
ADAM220.868
CDK140.867
RCAN20.867
AKT30.866
DCLK10.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGTRAP-0.454
TMEM176A-0.453
RHOD-0.452
CSAG1-0.447
TGIF1-0.443
EVC2-0.442
PDZK1IP1-0.441
RAB13-0.435
OR4F5-0.433
ROM1-0.429

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SUSD5 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SUSD5 mRNA"19114083
C006632arsenic trioxidearsenic trioxide results in increased expression of SUSD5 mRNA15761015
C006780bisphenol Abisphenol A results in increased methylation of SUSD5 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SUSD5 mRNA25181051
D002104CadmiumCadmium results in increased expression of SUSD5 mRNA21120746
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SUSD5 protein23301498
C069837fullerene C60fullerene C60 results in decreased expression of SUSD5 mRNA19167457
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SUSD5 mRNA28001369
D009532NickelNickel results in decreased expression of SUSD5 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of SUSD5 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SUSD5 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SUSD5 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SUSD5 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of SUSD5 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SUSD5 mRNA22714537
D015474IsotretinoinIsotretinoin results in increased expression of SUSD5 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SUSD5 mRNA25895662
D012906SmokeSmoke results in increased expression of SUSD5 mRNA21095227
C012589trichostatin Atrichostatin A results in decreased expression of SUSD5 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of SUSD5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SUSD5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SUSD5 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of SUSD5 mRNA22714537
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SUSD5 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005540hyaluronic acid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0007219Notch signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal