Gene: SIPA1L1

26037
E6TP1
signal induced proliferation associated 1 like 1
protein-coding
14q24.2
Ensembl:ENSG00000197555 MIM:617504 Vega:OTTHUMG00000171282 UniprotKB:O43166
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.808e-1 (AD)  5.189e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11158907chr14:71520348 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELF20.949
TANC20.947
DAPK10.945
IP6K10.94
SUGP20.94
CLASP10.938
CIT0.935
PDPK10.933
HTT0.933
KIAA07530.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.552
OR4F29-0.499
TFPI2-0.464
MYL3-0.445
CTNNA3-0.429
KLRB1-0.429
SNHG18-0.425
RAI14-0.421
SGMS2-0.418
SH2D1A-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SIPA1L1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SIPA1L1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SIPA1L1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SIPA1L1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SIPA1L1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SIPA1L1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SIPA1L1 mRNA22378314
D001280AtrazineAtrazine results in increased expression of SIPA1L1 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIPA1L1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIPA1L1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIPA1L1 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SIPA1L1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SIPA1L1 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of SIPA1L1 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of SIPA1L1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of SIPA1L1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of SIPA1L1 mRNA25270620
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SIPA1L1 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SIPA1L1 mRNA17484886
D003042CocaineCocaine affects the expression of SIPA1L1 mRNA20187946
D016572CyclosporineCyclosporine results in increased expression of SIPA1L1 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of SIPA1L1 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SIPA1L1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SIPA1L1 mRNA19561079|2739243
C000944dicrotophosdicrotophos results in increased expression of SIPA1L1 mRNA28302478
D004026DieldrinDieldrin results in increased expression of SIPA1L1 mRNA20438755
D004041Dietary FatsDietary Fats results in increased expression of SIPA1L1 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of SIPA1L1 mRNA]19030233
C042080diisodecyl phthalatediisodecyl phthalate results in decreased expression of SIPA1L1 mRNA25270620
C118739entinostatentinostat results in decreased expression of SIPA1L1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of SIPA1L1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SIPA1L1 mRNA22079256
D005419FlavonoidsFlavonoids results in increased expression of SIPA1L1 mRNA18035473
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SIPA1L1 mRNA17183730
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of SIPA1L1 mRNA19376150
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SIPA1L1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SIPA1L1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SIPA1L1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SIPA1L1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SIPA1L1 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of SIPA1L1 mRNA24768652
D010672PhenytoinPhenytoin results in increased expression of SIPA1L1 mRNA20345932
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIPA1L1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SIPA1L1 mRNA18301758|2381119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SIPA1L1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SIPA1L1 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of SIPA1L1 mRNA18037150
C089032rimonabantrimonabant affects the expression of SIPA1L1 mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of SIPA1L1 mRNA]19030233
C017947sodium arsenitesodium arsenite affects the expression of SIPA1L1 mRNA29319823
D018038Sodium SeleniteSodium Selenite results in increased expression of SIPA1L1 mRNA18175754
C016766sulforafansulforafan results in increased expression of SIPA1L1 mRNA26833863
D013629TamoxifenTamoxifen results in increased expression of SIPA1L1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIPA1L1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SIPA1L1 mRNA25975270
C009495titanium dioxidetitanium dioxide results in decreased expression of SIPA1L1 mRNA27760801
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SIPA1L1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SIPA1L1 mRNA28973697
D014520UrethaneUrethane results in increased expression of SIPA1L1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SIPA1L1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIPA1L1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SIPA1L1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of SIPA1L1 mRNA23179753|2718838
D014638VanadatesVanadates results in increased expression of SIPA1L1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SIPA1L1 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of SIPA1L1 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of SIPA1L1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of SIPA1L1 mRNA23555832
C029297vinylidene chloridevinylidene chloride results in decreased expression of SIPA1L1 mRNA26682919
D019287Zinc SulfateZinc Sulfate results in increased expression of SIPA1L1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005096GTPase activator activity-IEA-  
GO:0046875ephrin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0031532actin cytoskeleton reorganization-ISS-  
GO:0043087regulation of GTPase activity-ISS-  
GO:0048013ephrin receptor signaling pathway-ISS-  
GO:0048167regulation of synaptic plasticity-ISS-  
GO:0050770regulation of axonogenesis-ISS-  
GO:0051056regulation of small GTPase mediated signal transduction-IEA-  
GO:0061001regulation of dendritic spine morphogenesis-ISS-  
GO:0090630activation of GTPase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0014069postsynaptic density-ISS-  
GO:0030054cell junction-IEA-  
GO:0043197dendritic spine-ISS-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal