Gene info: ID 260425

Gene: MAGI3

GENE ID: 260425

Synonyms: MAGI-3|dJ730K3.2

Description: membrane associated guanylate kinase, WW and PDZ domain containing 3

Gene type: protein-coding

Location: 1p13.2

dbXrefs: Ensembl:ENSG00000081026 MIM:615943 Vega:OTTHUMG00000011737 UniprotKB:Q5TCQ9

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.586e-1 (AD) 2.788e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPM1L	0.964
GSK3B	0.958
GMPS	0.948
SYNJ1	0.947
VPS35	0.946
MTMR9	0.946
WDR47	0.945
DMXL2	0.945
KRAS	0.945
ATP6V1A	0.943

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.462
OR4F5	-0.454
HEY2	-0.443
RAB13	-0.437
MYL3	-0.421
ROM1	-0.42
RAI14	-0.419
MDFI	-0.412
BCL7C	-0.411
OR4F29	-0.41

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAGI3 mRNA	19933214
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of MAGI3 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAGI3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAGI3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAGI3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAGI3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of MAGI3 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MAGI3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MAGI3 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MAGI3 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAGI3 mRNA	16483693
D001280	Atrazine	Atrazine results in decreased expression of MAGI3 mRNA	25929836
C547126	AZM551248	AZM551248 results in decreased expression of MAGI3 mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MAGI3 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MAGI3 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAGI3 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MAGI3 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAGI3 mRNA	19770486
C006780	bisphenol A	bisphenol A results in decreased methylation of MAGI3 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of MAGI3 mRNA	25181051
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MAGI3 mRNA	27858113
D003033	Coal Tar	Coal Tar results in decreased expression of MAGI3 mRNA	27858113
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAGI3 mRNA	25562108
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of MAGI3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of MAGI3 mRNA	27392435
C070609	EMD 53998	EMD 53998 analog results in decreased expression of MAGI3 mRNA	24977338
C118739	entinostat	entinostat results in decreased expression of MAGI3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAGI3 mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MAGI3 mRNA	17555576
D005485	Flutamide	Flutamide results in decreased expression of MAGI3 mRNA	24793618
D005839	Gentamicins	Gentamicins results in decreased expression of MAGI3 mRNA	22061828
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of MAGI3 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of MAGI3 mRNA	27392435
C045463	leflunomide	leflunomide results in increased expression of MAGI3 mRNA	28988120
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of MAGI3 mRNA"	24972896
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of MAGI3 mRNA	29191790
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MAGI3 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MAGI3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MAGI3 mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in decreased expression of MAGI3 mRNA	22714537
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAGI3 mRNA	25729387
D052638	Particulate Matter	Particulate Matter results in increased expression of MAGI3 mRNA	24769257
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAGI3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of MAGI3 mRNA	26272509
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of MAGI3 mRNA	23608068
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MAGI3 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of MAGI3 mRNA	21632981
D012715	Sesame Oil	Sesame Oil results in increased expression of MAGI3 mRNA	29191790
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MAGI3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAGI3 mRNA	15328365
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAGI3 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of MAGI3 mRNA	25729387
C057693	troglitazone	troglitazone results in decreased expression of MAGI3 mRNA	28973697
D014520	Urethane	Urethane results in increased expression of MAGI3 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of MAGI3 mRNA	15885361
D014635	Valproic Acid	Valproic Acid affects the expression of MAGI3 mRNA	25979313
C111237	vorinostat	vorinostat results in decreased expression of MAGI3 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004385	guanylate kinase activity	-	NAS	10748157
GO:0005515	protein binding	-	IPI	10748157 16316992 16964398 20353789
GO:0005524	ATP binding	-	IEA	-
GO:0032947	protein-containing complex scaffold activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006915	apoptotic process	-	NAS	10748157
GO:0016032	viral process	-	IEA	-
GO:0035556	intracellular signal transduction	-	NAS	10748157
GO:0046037	GMP metabolic process	-	IEA	-
GO:0046328	regulation of JNK cascade	-	IEA	-
GO:0046710	GDP metabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005886	plasma membrane	-	IEA	-
GO:0005923	bicellular tight junction	-	IEA	-
GO:0016020	membrane	-	NAS	10748157
GO:0030054	cell junction	-	IDA	-

KEGG ID	KEGG Term
hsa04530	Tight junction

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25345847	The association of thyroid peroxidase antibody risk loci with susceptibility to and phenotype of Graves' disease. (2015 Oct)	Kus A	Clin Endocrinol (Oxf)