Gene: CNTNAP2

26047
AUTS15|CASPR2|CDFE|NRXN4|PTHSL1
contactin associated protein like 2
protein-coding
7q35-q36.1
Ensembl:ENSG00000174469 MIM:604569 Vega:OTTHUMG00000152743 UniprotKB:Q9UHC6
NG_007092.2
PubMed|SNP Mapped
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.882e-1 (AD)  8.730e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11771941chr7:147982443 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs2178771chr7:147966400 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs2707592chr7:147963361 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs851712chr7:147831639 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs10279700chr7:147271203 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25949550chr7:145814306CNTNAP22.870e-66Maternal smoking in pregnancy27040690
cg11207515chr7:146904205CNTNAP26.260e-12Maternal smoking in pregnancy27040690
cg16254309chr7:145814152CNTNAP23.340e-9Maternal smoking in pregnancy27040690
cg25949550chr7:145814306CNTNAP21.680e-119Maternal smoking in pregnancy27040690
cg11207515chr7:146904205CNTNAP21.930e-17Maternal smoking in pregnancy27040690
cg16254309chr7:145814152CNTNAP21.040e-14Maternal smoking in pregnancy27040690
cg21322436chr7:145812842CNTNAP23.830e-13Maternal smoking in pregnancy27040690
cg25949550chr7:145814306CNTNAP21.270e-115Maternal smoking in pregnancy27040690
cg11207515chr7:146904205CNTNAP21.500e-21Maternal smoking in pregnancy27040690
cg16254309chr7:145814152CNTNAP21.630e-14Maternal smoking in pregnancy27040690
cg21322436chr7:145812842CNTNAP22.400e-13Maternal smoking in pregnancy27040690
cg25949550chr7:145814306CNTNAP22.970e-9Maternal smoking in pregnancy27040690
cg11207515chr7:146904205CNTNAP21.640e-12Maternal smoking in pregnancy27040690
cg25949550chr7:145814306CNTNAP29.000e-25Smoking27651444
cg11207515chr7:146904205CNTNAP21.500e-18Smoking27651444
cg21322436chr7:145812842CNTNAP23.500e-18Smoking27651444
cg17372101chr7:147500722CNTNAP23.300e-14Smoking27651444
cg18804920chr7:146572638CNTNAP21.000e-9Smoking27651444
cg16254309chr7:145814152CNTNAP24.900e-9Smoking27651444
cg25949550chr7:145814306CNTNAP22.780e-21Tobacco smoking28225026
cg21322436chr7:145812842CNTNAP22.230e-20Tobacco smoking28225026
cg11207515chr7:146904205CNTNAP25.260e-17Tobacco smoking28225026
cg17372101chr7:147500722CNTNAP21.160e-8Tobacco smoking28225026
cg21322436chr7:145812842CNTNAP24.350e-26Smoking28686328
cg25949550chr7:145814306CNTNAP21.600e-15Smoking28686328
cg11207515chr7:146904205CNTNAP24.250e-12Smoking28686328
cg17372101chr7:147500722CNTNAP21.740e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRB20.975
DLGAP10.974
SYT130.972
GABRA10.972
FGF120.972
MYT1L0.971
SNAP910.971
NEGR10.97
AAK10.97
RBFOX10.97

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.548
CSAG1-0.541
RAB13-0.538
MYL3-0.532
RNF135-0.526
REST-0.523
RAI14-0.522
CMTM3-0.52
WWTR1-0.514
CHST14-0.513

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTNAP2 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CNTNAP2 mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTNAP2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTNAP2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTNAP2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTNAP2 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CNTNAP2 mRNA"20206263
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CNTNAP2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTNAP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTNAP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTNAP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTNAP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CNTNAP2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CNTNAP2 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CNTNAP2 gene27153756
D001151ArsenicArsenic affects the methylation of CNTNAP2 gene25304211
C044887beta-methylcholinebeta-methylcholine affects the expression of CNTNAP2 mRNA21179406
D019327Copper SulfateCopper Sulfate results in decreased expression of CNTNAP2 mRNA19549813
D003367CotinineCotinine affects the methylation of CNTNAP2 gene22851337
D002945CisplatinCNTNAP2 protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of CNTNAP2 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CNTNAP2 mRNA21527772
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNTNAP2 mRNA17942748
D004397FonofosFonofos results in increased methylation of CNTNAP2 promoter22847954
C492448ICG 001ICG 001 results in decreased expression of CNTNAP2 mRNA26191083
C008261lead acetatelead acetate results in decreased expression of CNTNAP2 mRNA20542052
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CNTNAP2 mRNA28001369
D000073878Palm OilPalm Oil results in increased expression of CNTNAP2 mRNA18042831
D010278ParathionParathion results in increased methylation of CNTNAP2 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CNTNAP2 mRNA"25510870
D011192Potassium DichromatePotassium Dichromate affects the expression of CNTNAP2 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of CNTNAP2 mRNA22238285
C043680ptaquilosideptaquiloside results in decreased expression of CNTNAP2 mRNA23274088
C017947sodium arsenitesodium arsenite affects the methylation of CNTNAP2 gene28589171
C012568terbufosterbufos results in increased methylation of CNTNAP2 promoter22847954
D013739TestosteroneTestosterone results in decreased expression of CNTNAP2 mRNA20403060
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNTNAP2 mRNA17942748
D019284ThapsigarginThapsigargin results in increased expression of CNTNAP2 mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of CNTNAP2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the methylation of CNTNAP2 gene26756918
C024746tobacco tartobacco tar results in decreased expression of CNTNAP2 mRNA19559774
D014212TretinoinTretinoin results in decreased expression of CNTNAP2 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTNAP2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CNTNAP2 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of CNTNAP2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CNTNAP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CNTNAP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CNTNAP2 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of CNTNAP2 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CNTNAP2 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of CNTNAP2 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of CNTNAP2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  26721881  
GO:0019899enzyme binding-IPI19166515  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007420brain development-TAS10624965  
GO:0007612learning-IMP18179893  
GO:0008038neuron recognition-NAS10624965  
GO:0019226transmission of nerve impulse-NAS11352571  
GO:0021756striatum development-IEP18179893  
GO:0021761limbic system development-IEP18179895  
GO:0021794thalamus development-IEP18179893  
GO:0021987cerebral cortex development-IEP18179893  18987363  
GO:0030534adult behavior-IMP18179893  
GO:0031175neuron projection development-ISS-  
GO:0035176social behavior-IMP18179893  19896112  
GO:0042297vocal learning-IMP19896112  
GO:0045163clustering of voltage-gated potassium channels-ISS-  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0071109superior temporal gyrus development-IEP18179893  
GO:0071205protein localization to juxtaparanode region of axon-ISS-  
GO:0071625vocalization behavior-IMP18179893  19896112  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IDA19706678  
GO:0005794Golgi apparatus-IDA19166515  
GO:0008076voltage-gated potassium channel complex-IDA10624965  
GO:0008076voltage-gated potassium channel complex-NAS10624965  
GO:0009986cell surface-IDA19706678  
GO:0016020membrane-IDA10624965  
GO:0016021integral component of membrane-NAS11352571  
GO:0030424axon-NAS19706678  
GO:0030425dendrite-NAS10624965  
GO:0030673axolemma-IDA19706678  
GO:0033010paranodal junction-IEA-  
GO:0043025neuronal cell body-NAS10624965  
GO:0043204perikaryon-NAS19166515  
GO:0044224juxtaparanode region of axon-ISS-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25862628DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)Kupers LKInt J Epidemiol
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer
25041903TARV: tree-based analysis of rare variants identifying risk modifying variants in CTNNA2 and CNTNAP2 for alcohol addiction. (2014 Sep)Song CGenet Epidemiol
25552657Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). (2015 Apr 15)Richmond RCHum Mol Genet
27171005Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study. (2016)Rzehak PPLoS One
25325234Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age. (2015 Feb)Lee KWEnviron Health Perspect
29695247Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. (2018 Apr 25)Witt SHBMC Genomics