Gene: PPP1R16B

26051
ANKRD4|TIMAP
protein phosphatase 1 regulatory subunit 16B
protein-coding
20q11.23
Ensembl:ENSG00000101445 MIM:613275 Vega:OTTHUMG00000032465 UniprotKB:Q96T49
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.776e-1 (AD)  6.272e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10392chr20:38922292 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO410.909
PIP4K2B0.908
EPB41L10.907
SBF10.906
RIMS40.902
CBX60.898
KLF130.897
HCN20.897
AGAP20.896
IQSEC10.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.625
OR4F29-0.619
C9orf135-0.453
PRRX2-0.453
S100A3-0.449
PDZK1IP1-0.427
TFPI2-0.423
PIRT-0.421
ZNF114-0.42
DNAI2-0.408

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PPP1R16B gene27153756
D001151ArsenicArsenic affects the methylation of PPP1R16B gene25304211
C015001arsenitearsenite results in increased expression of PPP1R16B mRNA23974009
D001280AtrazineAtrazine results in decreased expression of PPP1R16B mRNA22378314
D001554BenzeneBenzene results in increased expression of PPP1R16B mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPP1R16B mRNA21569818
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PPP1R16B mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of PPP1R16B mRNA25181051
D002104CadmiumCadmium results in decreased expression of PPP1R16B mRNA24376830
D002166CamptothecinPPP1R16B mRNA results in decreased susceptibility to Camptothecin25269479
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R16B gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R16B gene20938992
D007501IronIron deficiency results in increased expression of PPP1R16B mRNA20368581
D007854LeadLead affects the expression of PPP1R16B mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R16B gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PPP1R16B mRNA28001369
D009532NickelNickel results in increased expression of PPP1R16B mRNA24768652|2558310
D010634PhenobarbitalPhenobarbital affects the expression of PPP1R16B mRNA23091169
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PPP1R16B mRNA17404688
C005556propionaldehydepropionaldehyde results in decreased expression of PPP1R16B mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPP1R16B mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of PPP1R16B mRNA20436886
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of PPP1R16B mRNA"21148743
D012906SmokeSmoke results in decreased expression of PPP1R16B mRNA21095227
D053260SootSoot results in increased expression of PPP1R16B mRNA26551751
D013654TaurineTaurine results in increased expression of PPP1R16B mRNA16579726
D019284ThapsigarginThapsigargin results in decreased expression of PPP1R16B mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of PPP1R16B mRNA23557971
D014212TretinoinTretinoin results in increased expression of PPP1R16B mRNA23724009
D014415TunicamycinTunicamycin results in decreased expression of PPP1R16B mRNA22378314
D014640VancomycinVancomycin results in increased expression of PPP1R16B mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PPP1R16B gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PPP1R16B mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16263087  18586956  25007873  25416956  26497934  27107012  
28330616  
GO:0019888protein phosphatase regulator activity-IDA16263087  
GO ID GO Term Qualifier Evidence PubMed
GO:0001938positive regulation of endothelial cell proliferation-IMP25007873  
GO:0014066regulation of phosphatidylinositol 3-kinase signaling-IMP25007873  
GO:0035304regulation of protein dephosphorylation-IMP26497934  
GO:0035307positive regulation of protein dephosphorylation-IDA16263087  
GO:0035308negative regulation of protein dephosphorylation-IDA21466834  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO:0051489regulation of filopodium assembly-ISS-  
GO:0061028establishment of endothelial barrier-IMP18586956  
GO:1902309negative regulation of peptidyl-serine dephosphorylation-IMP25007873  
GO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IMP25007873  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12055102  18586956  
GO:0005886plasma membrane-IDA12055102  16263087  18586956  26497934  
GO:0016607nuclear speck-IDA-  
GO:0042995cell projection-IDA25007873  
GO:0048471perinuclear region of cytoplasm-IDA12055102  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal