Gene: DNM3

26052
Dyna III
dynamin 3
protein-coding
1q24.3
Ensembl:ENSG00000197959 MIM:611445 Vega:OTTHUMG00000034913 UniprotKB:Q9UQ16
NC_000001.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.114e-1 (AD)  9.958e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6698987chr1:172399827 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02338271chr1:171868115DNM35.300e-14Smoking27651444
cg16696002chr1:172189728DNM31.500e-12Smoking27651444
cg07802362chr1:172313798DNM31.030e-11Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC60.966
SRPK20.961
NAPG0.958
SLC25A460.958
CHIC10.956
PIK3CB0.956
KIF3A0.956
TRIM370.953
PRKACB0.953
KIFAP30.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.502
CSAG1-0.496
RNF135-0.464
EVC2-0.461
OR4F29-0.456
SYDE1-0.454
RHOD-0.45
PDZK1IP1-0.441
MTRNR2L10-0.431
RUNX3-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of DNM3 protein"21673325
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DNM3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNM3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DNM3 mRNA19770486
D000447AldehydesAldehydes results in increased expression of DNM3 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of DNM3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DNM3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DNM3 mRNA24449571
D001151ArsenicArsenic affects the methylation of DNM3 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of DNM3 mRNA26705709
C006780bisphenol Abisphenol A results in increased methylation of DNM3 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of DNM3 mRNA26079696
D003042CocaineCocaine affects the expression of DNM3 mRNA20187946
D003471CuprizoneCuprizone results in increased expression of DNM3 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of DNM3 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DNM3 mRNA21266533
C118739entinostatentinostat results in increased expression of DNM3 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DNM3 mRNA22079256
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DNM3 gene27776689
C540355fenamidonefenamidone results in decreased expression of DNM3 mRNA27029645
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DNM3 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of DNM3 mRNA21889194
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DNM3 mRNA"20188158|2625132
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNM3 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of DNM3 mRNA22714537
C046012pentanalpentanal results in increased expression of DNM3 mRNA26079696
D010634PhenobarbitalPhenobarbital results in decreased expression of DNM3 mRNA19084549
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNM3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DNM3 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of DNM3 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DNM3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DNM3 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of DNM3 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of DNM3 mRNA21795739
C005556propionaldehydepropionaldehyde results in increased expression of DNM3 mRNA26079696
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of DNM3 mRNA19617259
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DNM3 mRNA25895662
D014212TretinoinTretinoin results in increased expression of DNM3 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of DNM3 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of DNM3 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNM3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DNM3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DNM3 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DNM3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-ISS-  
GO:0005515protein binding-IPI15252009  
GO:0005525GTP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0031798type 1 metabotropic glutamate receptor binding-IEA-  
GO:0031802type 5 metabotropic glutamate receptor binding-IEA-  
GO:0050998nitric-oxide synthase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-ISS-  
GO:0007416synapse assembly-ISS-  
GO:0010020chloroplast fission-IBA21873635  
GO:0016185synaptic vesicle budding from presynaptic endocytic zone membrane-IBA21873635  
GO:0016185synaptic vesicle budding from presynaptic endocytic zone membrane-IEA-  
GO:0016559peroxisome fission-IBA21873635  
GO:0031623receptor internalization-IBA21873635  
GO:0046847filopodium assembly-ISS-  
GO:0048285organelle fission-IBA21873635  
GO:0050803regulation of synapse structure or activity-IBA21873635  
GO:0051491positive regulation of filopodium assembly-IEA-  
GO:0061002negative regulation of dendritic spine morphogenesis-IEA-  
GO:0098884postsynaptic neurotransmitter receptor internalization-IBA21873635  
GO:0098884postsynaptic neurotransmitter receptor internalization-IEA-  
GO:1903423positive regulation of synaptic vesicle recycling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005777peroxisome-IBA21873635  
GO:0005794Golgi apparatus-IEA-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0009507chloroplast-IBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-ISS-  
GO:0015630microtubule cytoskeleton-IBA21873635  
GO:0016020membrane-IBA21873635  
GO:0030424axon-IBA21873635  
GO:0030424axon-IEA-  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0043083synaptic cleft-IEA-  
GO:0043197dendritic spine-IBA21873635  
GO:0043197dendritic spine-ISS-  
GO:0044327dendritic spine head-IBA21873635  
GO:0044327dendritic spine head-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:0061828apical tubulobulbar complex-IEA-  
GO:0061829basal tubulobulbar complex-IEA-  
GO:0070062extracellular exosome-HDA23533145  
GO:0098844postsynaptic endocytic zone membrane-IBA21873635  
GO:0098844postsynaptic endocytic zone membrane-IEA-  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04666Fc gamma R-mediated phagocytosis
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-177504Retrograde neurotrophin signallingIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-437239Recycling pathway of L1TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes