Gene: GIGYF2

26058
GYF2|PARK11|PERQ2|PERQ3|TNRC15
GRB10 interacting GYF protein 2
protein-coding
2q37.1
Ensembl:ENSG00000204120 MIM:612003 Vega:OTTHUMG00000153237 UniprotKB:Q6Y7W6
NG_011847.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.554e-2 (AD)  1.049e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF3A0.908
CDC42BPA0.908
DCAF70.904
KIDINS2200.899
WDFY30.899
TGOLN20.898
KIAA20260.898
MCM3AP0.897
TM7SF30.894
RABGAP10.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.622
OR4F29-0.617
OR4F16-0.268
MTRNR2L6-0.262
MTRNR2L10-0.233
MTRNR2L9-0.229
C17orf112-0.228
S100A14-0.222
NANOGNB-0.222
MOGAT2-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of GIGYF2 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of GIGYF2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of GIGYF2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GIGYF2 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of GIGYF2 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GIGYF2 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of GIGYF2 mRNA25929836
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GIGYF2 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GIGYF2 mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of GIGYF2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of GIGYF2 mRNA21786754
D019327Copper SulfateCopper Sulfate results in decreased expression of GIGYF2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of GIGYF2 mRNA27523638
D003703DemecolcineDemecolcine results in increased expression of GIGYF2 mRNA23649840
D004041Dietary FatsDietary Fats results in decreased expression of GIGYF2 mRNA25016146
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GIGYF2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GIGYF2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GIGYF2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GIGYF2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GIGYF2 mRNA17942748
D005557FormaldehydeFormaldehyde results in increased expression of GIGYF2 mRNA23649840
D007545IsoproterenolIsoproterenol results in increased expression of GIGYF2 mRNA20003209
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GIGYF2 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of GIGYF2 mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GIGYF2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GIGYF2 mRNA"26251327
D009151Mustard GasMustard Gas results in increased phosphorylation of GIGYF2 protein19845377
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of GIGYF2 mRNA"29244179
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GIGYF2 mRNA25729387
C016030pantogabpantogab results in decreased expression of GIGYF2 mRNA17379144
D010634PhenobarbitalPhenobarbital affects the expression of GIGYF2 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of GIGYF2 mRNA23557933
C531249Poly(amidoamine)Poly(amidoamine) analog results in increased expression of GIGYF2 mRNA23806026
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GIGYF2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GIGYF2 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of GIGYF2 mRNA21278054
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GIGYF2 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GIGYF2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GIGYF2 mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of GIGYF2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GIGYF2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of GIGYF2 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of GIGYF2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of GIGYF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GIGYF2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GIGYF2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of GIGYF2 mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of GIGYF2 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of GIGYF2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI20670374  20696395  20878056  27157137  
GO:0045296cadherin binding-HDA25468996  
GO:0070064proline-rich region binding-IDA20696395  
GO ID GO Term Qualifier Evidence PubMed
GO:0007631feeding behavior-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0016441posttranscriptional gene silencing-IDA27157137  
GO:0017148negative regulation of translation-IMP22751931  
GO:0021522spinal cord motor neuron differentiation-IEA-  
GO:0031571mitotic G1 DNA damage checkpoint-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0044267cellular protein metabolic process-IEA-  
GO:0048009insulin-like growth factor receptor signaling pathway-IMP20670374  
GO:0048873homeostasis of number of cells within a tissue-IEA-  
GO:0050881musculoskeletal movement-IEA-  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0061157mRNA destabilization-IDA27157137  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IDA20670374  
GO:0005783endoplasmic reticulum-IDA20696395  
GO:0005794Golgi apparatus-IDA20696395  
GO:0005829cytosol-IDA-  
GO:0010494cytoplasmic stress granule-IDA20696395  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0032991protein-containing complex-IDA20878056  
GO:0043204perikaryon-IDA20670374  
GO:1990635proximal dendrite-IDA20670374  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28209224Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)Webb TRJ Am Coll Cardiol