Gene: KLK13

26085
KLK-L4|KLKL4
kallikrein related peptidase 13
protein-coding
19q13.41
Ensembl:ENSG00000167759 MIM:605505 Vega:OTTHUMG00000182912 UniprotKB:Q9UKR3
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.358e-2 (AD)  8.998e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC210.789
SERPINB30.777
SPRR2D0.769
KRT40.765
TMPRSS11B0.761
SPINK50.759
CRNN0.758
CSTA0.754
SPRR2A0.747
SPRR30.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGAP4-0.214
TKTL2-0.195
TINAG-0.189
PAX3-0.189
CCDC171-0.184
ASPM-0.182
DTWD2-0.18
ZBTB43-0.179
STARD4-AS1-0.178
C1orf127-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLK13 gene27153756
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of KLK13 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of KLK13 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLK13 mRNA22300585
C006780bisphenol Abisphenol A results in decreased expression of KLK13 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KLK13 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of KLK13 promoter22457795
D003300CopperCopper deficiency results in increased expression of KLK13 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of KLK13 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of KLK13 mRNA16002434
D005557FormaldehydeFormaldehyde results in increased expression of KLK13 mRNA27664576
D007854LeadLead results in decreased expression of KLK13 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KLK13 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KLK13 mRNA"25554681
D009532NickelNickel results in increased expression of KLK13 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of KLK13 mRNA19167457
D011441PropylthiouracilPropylthiouracil results in decreased expression of KLK13 mRNA24780913
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of KLK13 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK13 mRNA23152189
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KLK13 mRNA18087596
D014212TretinoinTretinoin results in increased expression of KLK13 mRNA16249480
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLK13 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-NAS10766816  
GO:0005515protein binding-IPI14687906  
GO:0016787hydrolase activity-IDA14687906  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-NAS10766816  
GO:0016485protein processing-IEA-  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS10766816  
GO:0005615extracellular space-IEA-  
GO:0005737cytoplasm-IDA12642628  
GO:0030141secretory granule-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res