Gene: GGA1

26088
-
golgi associated, gamma adaptin ear containing, ARF binding protein 1
protein-coding
22q13.1
Ensembl:ENSG00000100083 MIM:606004 Vega:OTTHUMG00000030985 UniprotKB:Q9UJY5
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.115e-2 (AD)  3.506e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3761442chr22:37607063 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTR10.935
GAK0.934
MTA10.933
TMEM2590.931
RBM100.931
PTPN230.926
POLRMT0.926
SNRNP700.925
TBC1D170.925
XAB20.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.749
OR4F29-0.713
MTRNR2L6-0.29
MTRNR2L9-0.288
MTRNR2L10-0.267
HBD-0.258
OR6C74-0.246
DNASE1L3-0.244
AGTR1-0.244
TTLL10-AS1-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of GGA1 mRNA25716159
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to GGA1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GGA1 protein]26598702
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GGA1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GGA1 mRNA21298039
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GGA1 protein]26598702
D001554BenzeneBenzene results in increased expression of GGA1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GGA1 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of GGA1 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GGA1 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of GGA1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of GGA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GGA1 gene28505145
C100187chloropicrinchloropicrin results in increased expression of GGA1 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of GGA1 mRNA19376846
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GGA1 mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GGA1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GGA1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GGA1 mRNA17942748
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of GGA1 mRNA17572062
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GGA1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GGA1 mRNA28628672
C028007nickel monoxidenickel monoxide results in increased expression of GGA1 mRNA19167457
D011374ProgesteroneProgesterone affects the expression of GGA1 mRNA17251523
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GGA1 mRNA25895662
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GGA1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GGA1 mRNA17942748
D013752TetracyclineTetracycline results in increased expression of GGA1 mRNA16917069

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI10747089  11387475  11390366  11821067  12505986  12767220  
14637142  15143060  15231748  15457209  17855360  18418388  
20676133  22522702  25416956  
GO:0030306ADP-ribosylation factor binding-IPI12668765  12679809  
GO:0046982protein heterodimerization activity-IMP12668765  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-TAS20211637  
GO:0016192vesicle-mediated transport-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:1901998toxin transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005794Golgi apparatus-TAS20214818  
GO:0010008endosome membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030131clathrin adaptor complex-IEA-  
GO:0031901early endosome membrane-TAS-  
GO:0032991protein-containing complex-IMP12668765  12679809  12767220  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-9007101Rab regulation of traffickingTAS
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal