Gene: WSB1

26118
SWIP1|WSB-1
WD repeat and SOCS box containing 1
protein-coding
17q11.1
Ensembl:ENSG00000109046 MIM:610091 Vega:OTTHUMG00000132293 UniprotKB:Q9Y6I7
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.361e-2 (AD)  2.985e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11080131chr17:27309928 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIA10.897
NKTR0.893
RBM250.887
CREBZF0.887
DMTF10.885
WDR110.869
SRRM10.869
FNBP40.868
ZKSCAN10.868
RBM50.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.575
OR4F29-0.557
FOXJ1-0.266
MOGAT2-0.233
MTRNR2L6-0.219
MTRNR2L9-0.214
EPPIN-0.203
PLA2G5-0.2
EVC2-0.196
MTRNR2L10-0.192

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of WSB1 mRNA"21920950
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of WSB1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of WSB1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WSB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WSB1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of WSB1 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of WSB1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of WSB1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WSB1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of WSB1 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of WSB1 mRNA28522335
C015001arsenitearsenite affects the expression of WSB1 mRNA22959463
D001280AtrazineAtrazine results in increased expression of WSB1 mRNA22378314
D001507BeclomethasoneBeclomethasone results in increased expression of WSB1 mRNA23656298
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of WSB1 mRNA18164116
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of WSB1 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WSB1 mRNA"20018196
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of WSB1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of WSB1 mRNA19619570
D004958EstradiolEstradiol affects the expression of WSB1 mRNA15598610
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of WSB1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of WSB1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of WSB1 mRNA25594700|2606340
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of WSB1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of WSB1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of WSB1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of WSB1 mRNA19010381
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of WSB1 mRNA27339419
C054133casticincasticin results in decreased expression of WSB1 mRNA28444820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of WSB1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WSB1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of WSB1 mRNA19376846|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of WSB1 mRNA]22202117
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of WSB1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of WSB1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of WSB1 mRNA20106945
D003634DDTDDT results in increased expression of WSB1 mRNA25014179
D003703DemecolcineDemecolcine results in decreased expression of WSB1 mRNA23649840
D004041Dietary FatsDietary Fats results in increased expression of WSB1 mRNA18042831|1903023
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of WSB1 mRNA]19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of WSB1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of WSB1 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of WSB1 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of WSB1 mRNA21592394
C024565ethylene dichlorideethylene dichloride results in increased expression of WSB1 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of WSB1 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in decreased expression of WSB1 mRNA]21318169
D005485FlutamideFlutamide results in decreased expression of WSB1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WSB1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of WSB1 mRNA23649840
C039281furanfuran results in decreased expression of WSB1 mRNA26194646
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of WSB1 mRNA22634610
C004312glycidolglycidol results in decreased expression of WSB1 mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of WSB1 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of WSB1 mRNA18927307
C410337K 7174K 7174 results in increased expression of WSB1 mRNA24086573
C018584linaloollinalool results in increased expression of WSB1 mRNA19922762
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of WSB1 mRNA12057914
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of WSB1 mRNA12057914
D008627Mercuric ChlorideMercuric Chloride affects the expression of WSB1 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of WSB1 mRNA27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WSB1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WSB1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WSB1 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of WSB1 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of WSB1 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of WSB1 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of WSB1 mRNA20971185
D000073878Palm OilPalm Oil results in increased expression of WSB1 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of WSB1 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of WSB1 mRNA24642059
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of WSB1 mRNA27153767
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of WSB1 mRNA24535843
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WSB1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of WSB1 mRNA20059764|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of WSB1 mRNA]21318169
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of WSB1 mRNA]20059764
D010936Plant ExtractsPlant Extracts results in increased expression of WSB1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of WSB1 mRNA28903501
C045362prochlorazprochloraz results in increased expression of WSB1 mRNA21470553
D011794QuercetinQuercetin results in increased expression of WSB1 mRNA19729006
C059514resveratrolresveratrol results in decreased expression of WSB1 mRNA20878097
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of WSB1 mRNA]19030233
D012643SeleniumSelenium results in decreased expression of WSB1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of WSB1 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of WSB1 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of WSB1 mRNA23922661
C017947sodium arsenitesodium arsenite affects the expression of WSB1 mRNA29319823
C017947sodium arsenitesodium arsenite results in decreased expression of WSB1 mRNA28595984
D013311StreptozocinStreptozocin results in decreased expression of WSB1 mRNA25905778
D013629TamoxifenTamoxifen affects the expression of WSB1 mRNA20937368
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of WSB1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of WSB1 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of WSB1 mRNA26496021
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of WSB1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WSB1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WSB1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of WSB1 mRNA25613284
C483909torcetrapibtorcetrapib results in increased expression of WSB1 mRNA23228038
D014112ToxapheneToxaphene results in decreased expression of WSB1 mRNA23153324
D014212TretinoinTretinoin results in decreased expression of WSB1 mRNA20530235
D014212TretinoinTretinoin results in increased expression of WSB1 mRNA15894607
D017974Uranium CompoundsUranium Compounds results in decreased expression of WSB1 mRNA19654044
D014520UrethaneUrethane results in increased expression of WSB1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WSB1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of WSB1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of WSB1 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of WSB1 gene25560391
D014750VincristineVincristine results in decreased expression of WSB1 mRNA23649840
D014800VitalliumVitallium analog results in decreased expression of WSB1 mRNA23825117
C111237vorinostatvorinostat results in decreased expression of WSB1 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of WSB1 mRNA18593933
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of WSB1 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI18093972  27273569  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0008150biological_process-ND-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal