Gene: SENP3

26168
SMT3IP1|SSP3|Ulp1
SUMO specific peptidase 3
protein-coding
17p13.1
Ensembl:ENSG00000161956 MIM:612844 Vega:OTTHUMG00000178333 UniprotKB:Q9H4L4
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIP4K2B0.954
OTUD50.953
STK250.95
CALM10.948
DEF80.948
FXR20.947
GNB10.945
KLHDC30.943
NGRN0.943
ASNA10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.789
OR4F29-0.756
TFPI2-0.389
IL18RAP-0.387
KCNJ15-0.368
KLRB1-0.356
CXCR2-0.356
CST7-0.347
KLRF1-0.343
CEACAM3-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SENP3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SENP3 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SENP3 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SENP3 mRNA17562736
D001280AtrazineAtrazine results in increased expression of SENP3 mRNA25929836
D001374AzacitidineAzacitidine results in increased expression of SENP3 mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of SENP3 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SENP3 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of SENP3 mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SENP3 protein28747609
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SENP3 promoter22457795
D019256Cadmium ChlorideSENP3 protein affects the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]28747609
C018021cobaltous chloridecobaltous chloride results in decreased expression of SENP3 mRNA19320972|1937684
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SENP3 protein23301498
D005485FlutamideFlutamide results in increased expression of SENP3 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SENP3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SENP3 mRNA23430699
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]22094256
D010634PhenobarbitalPhenobarbital results in decreased expression of SENP3 mRNA16940010
C006253pirinixic acidpirinixic acid results in increased expression of SENP3 mRNA16940010
D010936Plant ExtractsPlant Extracts results in increased expression of SENP3 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SENP3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of SENP3 protein23298284
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SENP3 mRNA25613284
D014635Valproic AcidValproic Acid results in decreased expression of SENP3 mRNA19101580|2352703

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18259216  19680224  21326211  
GO:0008234cysteine-type peptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006364rRNA processing-TAS-  
GO:0016926protein desumoylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0071339MLL1 complex-IDA15960975  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27181202SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. (2016 Nov 10)Zhou ZOncogene
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One