Gene: GARS

2617
CMT2D|DSMAV|GlyRS|HMN5|SMAD1
glycyl-tRNA synthetase
protein-coding
7p14.3
Ensembl:ENSG00000106105 MIM:600287 Vega:OTTHUMG00000152769 UniprotKB:P41250
NG_007942.1
PubMed
0   ANCO-SNPs
OD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.148e-1 (AD)  6.266e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03068497chr7:30635838GARS2.580e-10Alcohol consumption der day27843151
cg19390658chr7:30636176GARS9.180e-9Alcohol consumption der day27843151
cg21429551chr7:30635762GARS1.430e-11Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SARS0.979
CIAPIN10.971
VDAC10.97
YARS0.969
DDX240.966
PRPF190.965
ATP6V1B20.963
GOT20.959
ASNS0.958
PPME10.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.617
OR4F29-0.568
ASB4-0.412
MYOM1-0.397
RAI14-0.385
MBNL3-0.383
KLRB1-0.378
CXCR2-0.368
PARD3B-0.368
VNN3-0.364

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of GARS mRNA19041380
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GARS mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GARS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GARS mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of GARS protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GARS mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of GARS mRNA"19561079
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of GARS mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GARS mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GARS mRNA25704631
D000082AcetaminophenAcetaminophen results in increased expression of GARS mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GARS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GARS mRNA21632981
C006632arsenic trioxidearsenic trioxide results in increased expression of GARS mRNA20458559
D001205Ascorbic AcidAscorbic Acid results in decreased expression of GARS mRNA19197388
C547126AZM551248AZM551248 results in increased expression of GARS mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GARS mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GARS mRNA21715664
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GARS mRNA"20018196
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GARS mRNA20823114
D004958EstradiolEstradiol results in increased expression of GARS mRNA20106945
C095105bexarotenebexarotene results in decreased expression of GARS mRNA17178900
C006780bisphenol Abisphenol A results in increased expression of GARS mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of GARS protein24909818
C006780bisphenol Abisphenol A affects the expression of GARS mRNA25181051
D002065BuspironeBuspirone results in decreased expression of GARS mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GARS mRNA15003993
C584509C646 compoundC646 compound results in increased expression of GARS mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GARS mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GARS mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GARS protein21699967
D002220CarbamazepineCarbamazepine affects the expression of GARS mRNA24752500|2597931
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GARS mRNA27339419
C004656chloroacetaldehydechloroacetaldehyde affects the expression of GARS mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GARS mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GARS mRNA26272509
C100187chloropicrinchloropicrin affects the expression of GARS mRNA26352163
C059262cidofovircidofovir results in increased expression of GARS mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of GARS mRNA25596134
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GARS mRNA17602206
D019327Copper SulfateCopper Sulfate results in increased expression of GARS mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of GARS mRNA20106945|2116390
D016572CyclosporineCyclosporine results in increased expression of GARS mRNA25596134
D013759DronabinolDronabinol affects the expression of GARS mRNA18454173
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GARS mRNA20823114
D002945CisplatinCisplatin results in increased expression of GARS mRNA25596134
D002945CisplatinGARS protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac affects the expression of GARS mRNA24752500
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of GARS mRNA15784690
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GARS mRNA17602206
D004178DiquatDiquat affects the expression of GARS mRNA22814884
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GARS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GARS mRNA20227414
D011345FenofibrateFenofibrate results in increased expression of GARS mRNA25596134
D018120FinasterideFinasteride results in increased expression of GARS mRNA24136188
D005485FlutamideFlutamide results in increased expression of GARS mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of GARS mRNA16221962
C419708gefitinibgefitinib results in increased expression of GARS mRNA16685379
C492448ICG 001ICG 001 results in increased expression of GARS mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of GARS mRNA25596134
C020758indium trichlorideindium trichloride results in decreased expression of GARS protein19539025
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GARS mRNA25613284
C410337K 7174K 7174 results in increased expression of GARS mRNA24086573
C045463leflunomideleflunomide results in increased expression of GARS mRNA28988120
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GARS mRNA20823114
D008687MetforminMetformin results in increased expression of GARS mRNA25596134
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GARS mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GARS mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GARS mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GARS protein26558463
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GARS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GARS mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GARS mRNA20551477
C051752nefazodonenefazodone results in increased expression of GARS mRNA24136188
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of GARS mRNA"16823509
D043371Fatty Acids, Omega-6"Fatty Acids, Omega-6 results in decreased expression of GARS mRNA"16823509
D010100OxygenOxygen deficiency results in decreased expression of GARS mRNA25596134
D010416PentachlorophenolPentachlorophenol results in decreased expression of GARS mRNA24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of GARS mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GARS protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of GARS mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of GARS mRNA19084549
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GARS mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GARS mRNA19482888
D010936Plant ExtractsPlant Extracts results in increased expression of GARS mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of GARS mRNA18037150
D018038Sodium SeleniteSodium Selenite results in increased expression of GARS mRNA18175754
C025462sulindac sulfidesulindac sulfide results in increased expression of GARS mRNA12734198
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GARS mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GARS mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of GARS mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GARS mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of GARS mRNA22378314
D014212TretinoinTretinoin results in decreased expression of GARS mRNA16140955
D014241TrichloroethyleneTrichloroethylene results in increased expression of GARS mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GARS mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of GARS mRNA22378314
D014520UrethaneUrethane results in increased expression of GARS mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of GARS mRNA18422935
D014635Valproic AcidValproic Acid affects the expression of GARS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GARS mRNA23179753|2915479
D014635Valproic AcidValproic Acid affects the expression of GARS mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GARS gene25560391
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of GARS mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004081bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity-IDA19710017  
GO:0004820glycine-tRNA ligase activity-IBA21873635  
GO:0004820glycine-tRNA ligase activity-IDA17544401  17545306  19710017  
GO:0004820glycine-tRNA ligase activity-IMP28675565  
GO:0004820glycine-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI17545306  17595294  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IPI17545306  17595294  
GO:0046983protein dimerization activity-IDA17544401  17545306  
GO ID GO Term Qualifier Evidence PubMed
GO:0006418tRNA aminoacylation for protein translation-IMP28675565  
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006426glycyl-tRNA aminoacylation-IBA21873635  
GO:0015966diadenosine tetraphosphate biosynthetic process-IDA19710017  
GO:0070150mitochondrial glycyl-tRNA aminoacylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS7961834  
GO:0005739mitochondrion-IBA21873635  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0030141secretory granule-IEA-  
GO:0030424axon-IDA17035524  
GO:0070062extracellular exosome-ISS-  
KEGG ID KEGG Term
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-379726Mitochondrial tRNA aminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28930612Genetic addiction risk score (GARS) , a predictor of vulnerability to opioid dependence. (2018 Jan 1)Blum KFront Biosci (Elite Ed)