Gene: NPHP4

261734
POC10|SLSN4
nephrocystin 4
protein-coding
1p36.31
Ensembl:ENSG00000131697 MIM:607215 Vega:OTTHUMG00000000701 UniprotKB:O75161
NG_011724.2
PubMed
0   ANCO-SNPs
ND
1   
5.647e-1 (AD)  5.282e-1 (ND)   (Frontal_Cortex)
3.108e-1 (AD)  9.400e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPH10.91
SUGP20.904
QSOX20.899
ZFYVE280.897
TOP3A0.896
MYBBP1A0.893
ATP8B20.892
SNAPC40.891
DDX510.891
PPIL20.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.464
OR4F29-0.424
MYL3-0.396
MTRNR2L9-0.394
KLRC2-0.392
CTNNA3-0.386
MTRNR2L6-0.382
TRDN-0.376
MTRNR2L10-0.368
SH2D1A-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of NPHP4 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPHP4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPHP4 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to NPHP4 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to NPHP4 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPHP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPHP4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NPHP4 mRNA25064622
D000638AmiodaroneAmiodarone affects the expression of NPHP4 mRNA25064622
D001151ArsenicArsenic affects the methylation of NPHP4 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to NPHP4 protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPHP4 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of NPHP4 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of NPHP4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPHP4 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NPHP4 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of NPHP4 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPHP4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of NPHP4 mRNA26272509
D002746ChlorpromazineChlorpromazine affects the expression of NPHP4 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPHP4 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of NPHP4 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of NPHP4 mRNA25064622
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NPHP4 mRNA23914054
D002945CisplatinCisplatin results in decreased expression of NPHP4 mRNA27392435
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of NPHP4 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NPHP4 mRNA25064622
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPHP4 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of NPHP4 mRNA19167457
C004312glycidolglycidol results in increased expression of NPHP4 mRNA24915197
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NPHP4 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NPHP4 mRNA25613284
C042720mercuric bromidemercuric bromide results in decreased expression of NPHP4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPHP4 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NPHP4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NPHP4 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of NPHP4 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NPHP4 mRNA"25554681
D010269ParaquatParaquat affects the expression of NPHP4 mRNA25064622
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NPHP4 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of NPHP4 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of NPHP4 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NPHP4 promoter]19654925
D013752TetracyclineTetracycline affects the expression of NPHP4 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NPHP4 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of NPHP4 mRNA25064622
C009495titanium dioxidetitanium dioxide affects the expression of NPHP4 mRNA23557971
D014212TretinoinTretinoin results in increased expression of NPHP4 mRNA16788091
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NPHP4 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of NPHP4 mRNA25064622
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NPHP4 mRNA17183730
D014635Valproic AcidValproic Acid analog results in decreased expression of NPHP4 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of NPHP4 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-NAS12006559  
GO:0005515protein binding-IPI12244321  15661758  16339905  17558407  20664800  21224891  
21565611  22654112  22863007  26638075  26644512  27173435  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS12244321  
GO:0007632visual behavior-NAS12205563  
GO:0030036actin cytoskeleton organization-NAS12006559  
GO:0030317flagellated sperm motility-IEA-  
GO:0035329hippo signaling-TAS-  
GO:0035845photoreceptor cell outer segment organization-IEA-  
GO:0045494photoreceptor cell maintenance-IEA-  
GO:0060041retina development in camera-type eye-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA22654112  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:0098609cell-cell adhesion-NAS12006559  
GO:1903348positive regulation of bicellular tight junction assembly-IMP19755384  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005813centrosome-IDA21399614  
GO:0005829cytosol-TAS-  
GO:0005911cell-cell junction-IDA21565611  
GO:0005923bicellular tight junction-IEA-  
GO:0032391photoreceptor connecting cilium-IEA-  
GO:0036064ciliary basal body-IEA-  
GO:0097470ribbon synapse-IEA-  
GO:0097546ciliary base-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2028269Signaling by HippoTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22797725Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. (2012 Jul 15)Dong JNat Genet