Gene: GART

2618
AIRS|GARS|GARTF|PAIS|PGFT|PRGS
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
protein-coding
21q22.11
Ensembl:ENSG00000159131 MIM:138440 Vega:OTTHUMG00000065628 UniprotKB:P22102
NG_029160.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.478e-1 (AD)  4.357e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX180.909
YME1L10.902
COPB10.899
SLC39A90.895
THUMPD30.893
RPRD1B0.891
COPB20.89
KPNB10.89
DCTN40.889
EPRS0.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.662
OR4F29-0.607
MTRNR2L6-0.246
MTRNR2L9-0.235
HMHB1-0.218
MTRNR2L10-0.204
OR6C74-0.203
OR4F16-0.195
RSPO1-0.184
TTLL10-0.18

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00642PemetrexedSmall Molecule137281-23-3Approved|InvestigationalTarget
DB02236Glycinamide RibonucleotideSmall MoleculeExperimentalTarget
DB03546N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GART mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GART mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GART mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of GART mRNA"21346803
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to GART protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GART protein]26598702
C1050656R-2',5'-thienyl-5,10-dideazatetrahydrofolic acid"6R-2',5'-thienyl-5,10-dideazatetrahydrofolic acid results in decreased activity of GART protein"21879757
D000082AcetaminophenAcetaminophen results in decreased expression of GART mRNA21420995
C105066AG 2034AG 2034 results in decreased activity of GART protein21879757
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GART mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GART mRNA24449571
D001151ArsenicArsenic affects the methylation of GART gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GART protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of GART protein19364129
C006632arsenic trioxidearsenic trioxide results in increased expression of GART mRNA22521957
C006632arsenic trioxidearsenic trioxide results in increased expression of GART protein25419056
C015001arsenitearsenite affects the expression of GART mRNA22959463
D001507BeclomethasoneBeclomethasone results in increased expression of GART mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GART mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of GART mRNA21179406
C006780bisphenol Abisphenol A affects the expression of GART mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GART mRNA20678512
C006780bisphenol Abisphenol A affects the expression of GART mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GART mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GART mRNA28628672
D002104CadmiumCadmium results in increased expression of GART mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GART mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GART mRNA23741332
D002220CarbamazepineCarbamazepine affects the expression of GART mRNA24752500
C007020chlorophyllinchlorophyllin analog results in decreased expression of GART protein22852132
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of GART mRNA28472532
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GART mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of GART mRNA19320972|1937684
D003300CopperCopper results in decreased expression of GART mRNA26293553
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of GART mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of GART mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of GART mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of GART mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GART mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GART mRNA28628672
C016366dibenzothiophenedibenzothiophene results in increased expression of GART mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GART mRNA17361019|2126653
D004008DiclofenacDiclofenac affects the expression of GART mRNA24752500
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GART mRNA17602206
D002117CalcitriolCalcitriol results in decreased expression of GART mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of GART mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GART protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GART mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GART mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GART mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GART mRNA23649840
D005472FluorouracilFluorouracil results in increased expression of GART mRNA19219653
D005557FormaldehydeFormaldehyde results in decreased expression of GART mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GART mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GART mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of GART mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GART mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GART mRNA28628672
C045894lometrexollometrexol results in decreased activity of GART protein8958188
D008727MethotrexateMethotrexate affects the expression of GART mRNA23897011
D008727MethotrexateMethotrexate results in decreased expression of GART mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GART mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GART mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GART mRNA24810058
D008777MethyltestosteroneMethyltestosterone results in decreased expression of GART mRNA29191790
C568952N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid"[SLC46A1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid] which results in decreased activity of GART protein"21879757
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GART mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GART mRNA"25554681
D009532NickelNickel results in decreased expression of GART mRNA23195993
D009532NickelNickel results in increased expression of GART mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GART mRNA25729387
D010269ParaquatParaquat results in decreased expression of GART mRNA21371552
D010269ParaquatParaquat results in increased expression of GART mRNA21371552
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in decreased expression of GART mRNA18593933
D000068437PemetrexedPemetrexed results in decreased activity of GART protein17465208
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GART mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GART protein26879310
D010936Plant ExtractsPlant Extracts results in increased expression of GART mRNA23557933
D011748PyrogallolPyrogallol results in increased expression of GART mRNA20362636
C016104sodium bichromatesodium bichromate results in increased expression of GART mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of GART protein28918527
D013629TamoxifenTamoxifen affects the expression of GART mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of GART mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of GART mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GART mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GART mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GART mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GART mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GART mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of GART mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GART mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GART mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of GART mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of GART mRNA16054129
C012589trichostatin Atrichostatin A results in increased expression of GART mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GART mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of GART mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GART mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of GART mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GART gene25560391
D014750VincristineVincristine results in decreased expression of GART mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of GART mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in decreased expression of GART mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004637phosphoribosylamine-glycine ligase activity-IBA21873635  
GO:0004637phosphoribosylamine-glycine ligase activity-TAS-  
GO:0004641phosphoribosylformylglycinamidine cyclo-ligase activity-IBA21873635  
GO:0004641phosphoribosylformylglycinamidine cyclo-ligase activity-TAS-  
GO:0004644phosphoribosylglycinamide formyltransferase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003360brainstem development-IEA-  
GO:0006164purine nucleotide biosynthetic process-IBA21873635  
GO:0006189'de novo' IMP biosynthetic process-IEA-  
GO:0006544glycine metabolic process-IEA-  
GO:0009113purine nucleobase biosynthetic process-IEA-  
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TAS-  
GO:0010033response to organic substance-IEA-  
GO:0010035response to inorganic substance-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0046084adenine biosynthetic process-IBA21873635  
GO:0046654tetrahydrofolate biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73817Purine ribonucleoside monophosphate biosynthesisTAS
R-HSA-8956320Nucleobase biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22738448[Risk factors for Tourette syndrome]. (2012 Jun)Zhang HYZhongguo Dang Dai Er Ke Za Zhi