| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| TLR8 | 0.76 |
| NABP1 | 0.757 |
| FPR3 | 0.75 |
| PARP15 | 0.731 |
| ALPK1 | 0.73 |
| CD300E | 0.73 |
| DAPP1 | 0.727 |
| FAM20A | 0.719 |
| ARHGAP15 | 0.719 |
| FPR2 | 0.718 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| ASPDH | -0.427 |
| ARSF | -0.408 |
| WFDC1 | -0.382 |
| CPLX3 | -0.381 |
| KCNIP3 | -0.36 |
| C15orf59 | -0.359 |
| WNT7A | -0.356 |
| CHRNA4 | -0.343 |
| HES6 | -0.342 |
| SLC29A4 | -0.34 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C051246 | 1-methylanthracene | [1-methylanthracene co-treated with fluoranthene] results in increased expression of PTPN22 mRNA | 28329830 |
| C009505 | 4,4'-diaminodiphenylmethane | "4,4'-diaminodiphenylmethane results in increased expression of PTPN22 mRNA" | 18648102 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of PTPN22 mRNA | 17562736 |
| D000535 | Aluminum | [APP protein modified form binds to Aluminum] which results in decreased expression of PTPN22 mRNA | 21298039 |
| D018501 | Antirheumatic Agents | Antirheumatic Agents results in decreased expression of PTPN22 mRNA | 24449571 |
| D001151 | Arsenic | Arsenic affects the methylation of PTPN22 gene | 25304211 |
| D001554 | Benzene | Benzene results in increased expression of PTPN22 mRNA | 19162166 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of PTPN22 mRNA | 22316170 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of PTPN22 mRNA | 21569818 |
| D004958 | Estradiol | Estradiol affects the expression of PTPN22 mRNA | 22574217 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of PTPN22 mRNA | 26364221 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of PTPN22 mRNA | 25181051 |
| D020111 | Chlorodiphenyl (54% Chlorine) | Chlorodiphenyl (54% Chlorine) results in decreased expression of PTPN22 mRNA | 23650126 |
| D003010 | Clorgyline | Clorgyline results in increased expression of PTPN22 mRNA | 19691856 |
| C007262 | deoxynivalenol | deoxynivalenol results in increased expression of PTPN22 mRNA | 15371230 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTPN22 mRNA" | 19480007 |
| D005020 | Ethyl Methanesulfonate | Ethyl Methanesulfonate results in increased expression of PTPN22 mRNA | 23649840 |
| C007738 | fluoranthene | [1-methylanthracene co-treated with fluoranthene] results in increased expression of PTPN22 mRNA | 28329830 |
| D005557 | Formaldehyde | Formaldehyde results in increased expression of PTPN22 mRNA | 23649840 |
| D005839 | Gentamicins | Gentamicins results in increased expression of PTPN22 mRNA | 22061828 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of PTPN22 mRNA | 18951874 |
| C525666 | I-C11 compound | I-C11 compound binds to and results in decreased activity of PTPN22 protein | 21190368 |
| C525666 | I-C11 compound | I-C11 compound results in decreased activity of PTPN22 protein | 21341673 |
| C051890 | irinotecan | irinotecan metabolite results in increased expression of PTPN22 mRNA | 15956246 |
| C051890 | irinotecan | irinotecan results in increased expression of PTPN22 mRNA | 15956246 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in decreased expression of PTPN22 mRNA | 21889194|2280244 |
| D058185 | Magnetite Nanoparticles | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PTPN22 mRNA | 26378955 |
| D058185 | Magnetite Nanoparticles | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of PTPN22 mRNA | 21641980 |
| D008713 | Methimazole | Methimazole results in increased expression of PTPN22 mRNA | 22504374 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in increased expression of PTPN22 mRNA | 23649840 |
| D009532 | Nickel | Nickel affects the expression of PTPN22 mRNA | 14575637 |
| D009532 | Nickel | Nickel results in increased expression of PTPN22 mRNA | 24768652 |
| D009532 | Nickel | trichostatin A inhibits the reaction [Nickel affects the expression of PTPN22 mRNA] | 14575637 |
| C568608 | PCI 5002 | [PCI 5002 co-treated with Zinc] results in increased expression of PTPN22 mRNA | 18593933 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of PTPN22 mRNA | 20813756 |
| C019536 | potassium bromate | potassium bromate affects the expression of PTPN22 mRNA | 27082013 |
| C019536 | potassium bromate | [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of PTPN22 mRNA] | 27082013 |
| D011441 | Propylthiouracil | Propylthiouracil results in increased expression of PTPN22 mRNA | 22504374 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of PTPN22 mRNA | 17879257 |
| D053260 | Soot | Soot results in increased expression of PTPN22 mRNA | 26551751 |
| D004113 | Succimer | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PTPN22 mRNA | 26378955 |
| D004113 | Succimer | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of PTPN22 mRNA | 21641980 |
| C016766 | sulforafan | sulforafan results in increased expression of PTPN22 mRNA | 26833863 |
| C009495 | titanium dioxide | titanium dioxide results in increased expression of PTPN22 mRNA | 23557971 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of PTPN22 mRNA | 16604517 |
| D014241 | Trichloroethylene | PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of PTPN22 mRNA] | 15363585 |
| C012589 | trichostatin A | trichostatin A inhibits the reaction [Nickel affects the expression of PTPN22 mRNA] | 14575637 |
| D014638 | Vanadates | Vanadates results in increased expression of PTPN22 mRNA | 22714537 |
| D014640 | Vancomycin | Vancomycin results in decreased expression of PTPN22 mRNA | 18930951 |
| D015032 | Zinc | [PCI 5002 co-treated with Zinc] results in increased expression of PTPN22 mRNA | 18593933 |
| D019287 | Zinc Sulfate | Zinc Sulfate results in increased expression of PTPN22 mRNA | 27504894 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0004725 | protein tyrosine phosphatase activity | - | IDA | 10068674 16461343 18056643 |
| GO:0004725 | protein tyrosine phosphatase activity | - | TAS | - |
| GO:0005515 | protein binding | - | IPI | 10068674 11882361 16461343 19167335 21719704 23871208 24658140 25040622 |
| GO:0016791 | phosphatase activity | - | IDA | 23991106 |
| GO:0017124 | SH3 domain binding | - | ISS | - |
| GO:0019900 | kinase binding | - | ISS | - |
| GO:0031625 | ubiquitin protein ligase binding | - | IPI | 23871208 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006470 | protein dephosphorylation | - | IDA | 10068674 |
| GO:0006470 | protein dephosphorylation | - | TAS | 21044313 |
| GO:0006914 | autophagy | - | IEA | - |
| GO:0010507 | negative regulation of autophagy | - | IMP | 23991106 |
| GO:0010628 | positive regulation of gene expression | - | IMP | 23871208 23991106 |
| GO:0010629 | negative regulation of gene expression | - | IMP | 23991106 |
| GO:0030217 | T cell differentiation | - | ISS | - |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway | - | IMP | 23991106 |
| GO:0032481 | positive regulation of type I interferon production | - | IMP | 23871208 |
| GO:0032496 | response to lipopolysaccharide | - | IMP | 23871208 |
| GO:0032720 | negative regulation of tumor necrosis factor production | - | IMP | 23991106 |
| GO:0032817 | regulation of natural killer cell proliferation | - | IDA | 20522204 |
| GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway | - | IMP | 23871208 |
| GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | - | IMP | 23871208 |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | - | IEA | - |
| GO:0035644 | phosphoanandamide dephosphorylation | - | ISS | - |
| GO:0043508 | negative regulation of JUN kinase activity | - | IMP | 23991106 |
| GO:0045088 | regulation of innate immune response | - | IC | 20522204 |
| GO:0050852 | T cell receptor signaling pathway | - | TAS | - |
| GO:0050855 | regulation of B cell receptor signaling pathway | - | NAS | 19265110 |
| GO:0050860 | negative regulation of T cell receptor signaling pathway | - | IDA | 18056643 |
| GO:0050868 | negative regulation of T cell activation | - | IMP | 18299186 |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | - | IMP | 23991106 |
| GO:0070433 | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | - | IMP | 23991106 |
| GO:0071225 | cellular response to muramyl dipeptide | - | IDA | 23991106 |
| GO:1900165 | negative regulation of interleukin-6 secretion | - | IMP | 23991106 |
| GO:1901222 | regulation of NIK/NF-kappaB signaling | - | IMP | 23991106 |
| GO:1902523 | positive regulation of protein K63-linked ubiquitination | - | IMP | 23871208 |
| GO:1902715 | positive regulation of interferon-gamma secretion | - | IMP | 23991106 |
| GO:1903753 | negative regulation of p38MAPK cascade | - | IMP | 23991106 |
| GO:2000483 | negative regulation of interleukin-8 secretion | - | IMP | 23991106 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005634 | nucleus | - | IDA | 10940933 |
| GO:0005737 | cytoplasm | - | IDA | 10068674 10940933 |
| GO:0005737 | cytoplasm | - | TAS | 20401454 |
| GO:0005829 | cytosol | - | TAS | - |
| GO:0009898 | cytoplasmic side of plasma membrane | - | IDA | 10940933 |
| GO:0048471 | perinuclear region of cytoplasm | - | IDA | 10068674 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-1280218 | Adaptive Immune System | TAS |
| R-HSA-168256 | Immune System | TAS |
| R-HSA-202403 | TCR signaling | TAS |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | TAS |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 24489016 | Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis. (2014 Jun) | Davis LA | Rheumatology (Oxford) |
| 20560812 | Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study. (2010 Nov) | Berglin E | Scand J Rheumatol |
| 15943829 | Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset. (2005 Jun) | Skorka A | Clin Endocrinol (Oxf) |
| 22891483 | [Genetic and environmental interactions on the development of rheumatoid arthritis]. (2012 May-Jun) | Malaise O | Rev Med Liege |
| 23637320 | Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis. (2013 Jul) | Taylor LH | J Rheumatol |
| 19252239 | [Recent advances in the pathogenesis of rheumatoid arthritis]. (2009 Mar) | Kawabata K | Clin Calcium |
| 24812286 | Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies. (2014 Oct) | Jiang X | Ann Rheum Dis |
| 19714585 | Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. (2009 Sep) | Morgan AW | Arthritis Rheum |
| 19898480 | Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. (2009 Dec) | Mahdi H | Nat Genet |
| 19427413 | Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis. (2010 Jan) | Szodoray P | Autoimmun Rev |
| 22994016 | [100 years of Hashimoto thyroiditis, still an intriguing disease]. (2011 Dec) | Baretic M | Acta Med Croatica |
| 29325864 | Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases. (2018 Mar) | Shukla SK | Microb Pathog |
| 25421156 | Role of genetic and non-genetic factors in the etiology of Graves' disease. (2015 Mar) | Marino M | J Endocrinol Invest |
| 17436241 | Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. (2007 May) | Kallberg H | Am J Hum Genet |
| 22242199 | Genetic factors of autoimmune thyroid diseases in Japanese. (2012) | Ban Y | Autoimmune Dis |
| 18240242 | Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. (2008 Feb) | Farragher TM | Arthritis Rheum |
| 21496252 | Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers. (2011 Apr 15) | Saevarsdottir S | Arthritis Res Ther |
| 19944780 | The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. (2010 Mar) | Tobon GJ | Autoimmun Rev |
| 22661643 | Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. (2013 May) | Lundberg K | Ann Rheum Dis |
| 19307103 | The etiology of autoimmune thyroid disease: a story of genes and environment. (2009 May-Jun) | Tomer Y | J Autoimmun |
| 22968483 | Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism. (2012 Dec) | Vos XG | Eur J Endocrinol |
| 22440825 | Relationship between area-level socio-economic deprivation and autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study. (2012 Oct) | Mackie SL | Ann Rheum Dis |
| 20125172 | Epidemiology: Interpreting studies of interactions between RA risk factors. (2010 Feb) | Karlson EW | Nat Rev Rheumatol |
| 16279844 | Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (2005 Oct) | Kurylowicz A | Thyroid |
| 20234359 | Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis. (2010 May) | Kochi Y | Nat Rev Rheumatol |
| 17941906 | Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease. (2008 Mar) | Kisiel B | Clin Endocrinol (Oxf) |
| 20080387 | The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. (2010 Aug) | Tobon GJ | J Autoimmun |
| 23613482 | Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study. (2014 Jun) | Bengtsson C | Ann Rheum Dis |
| 25231450 | Thyroid autoimmunity. (2014) | Wiersinga WM | Endocr Dev |
| 20061955 | The rheumatoid arthritis HLA-DRB1 shared epitope. (2010 May) | Holoshitz J | Curr Opin Rheumatol |
| 22128080 | Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden. (2012 Jun) | Arlestig L | Ann Rheum Dis |
| 17553139 | The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden. (2007) | Kokkonen H | Arthritis Res Ther |
| 20439292 | Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep) | van der Helm-van Mil AH | Ann Rheum Dis |
| 23290888 | The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs. (2013 Mar) | Svendsen AJ | J Autoimmun |
| 26293122 | Etiopathogenesis of Basedow's disease. Trends and current aspects. (2015) | Leporati P | Nuklearmedizin |
| 24779222 | [Classification and etiology of hyperthyroidism]. (2014 Mar) | Lacka K | Pol Merkur Lekarski |
| 21752868 | PTPN22 R620W genotype-phenotype correlation analysis and gene-environment interaction study in early rheumatoid arthritis: results from the ESPOIR cohort. (2011 Oct) | Salliot C | Rheumatology (Oxford) |
| 23288628 | Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct) | Kurko J | Clin Rev Allergy Immunol |
| 18462498 | Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. (2008) | Costenbader KH | Arthritis Res Ther |
| 17660221 | Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis. (2008 Apr) | Michou L | Ann Rheum Dis |
| 18466513 | Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15. (2007) | Mei L | BMC Proc |
| 20046016 | [Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec) | Ohmura K | Nihon Rinsho Meneki Gakkai Kaishi |
| 20453439 | Genetic background of tolerance breakdown in rheumatoid arthritis. (2010) | Kochi Y | Nihon Rinsho Meneki Gakkai Kaishi |
| 15838240 | Understanding the genetic contribution to rheumatoid arthritis. (2005 May) | van der Helm-van Mil AH | Curr Opin Rheumatol |
| 27613842 | Methylation and expression of PTPN22 in esophageal squamous cell carcinoma. (2016 Sep 27) | Deng J | Oncotarget |
| 18466575 | Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis. (2007) | Dempfle A | BMC Proc |
| 20192991 | Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. (2010 Jan) | Wegner N | Immunol Rev |