Gene: AMD1

262
ADOMETDC|AMD|SAMDC
adenosylmethionine decarboxylase 1
protein-coding
6q21
Ensembl:ENSG00000123505 MIM:180980 Vega:OTTHUMG00000015369 UniprotKB:P17707
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.989e-1 (AD)  1.174e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
API50.952
COPS20.946
UBE2G10.944
PAIP10.943
STX60.94
ARL6IP50.937
RUFY30.933
UBA20.932
SACM1L0.931
RAB140.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.658
MTRNR2L6-0.274
MTRNR2L10-0.272
CSAG1-0.262
NXNL1-0.255
ADAMTSL5-0.254
ZBTB20-0.254
KCNK5-0.253
MTRNR2L9-0.252

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalTarget
DB01917PutrescineSmall Molecule110-60-1ExperimentalTarget
DB03754TromethamineSmall Molecule77-86-1ApprovedTarget
DB081635'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of AMD1 mRNA"19162173
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of AMD1 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AMD1 mRNA"19167446
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased activity of AMD1 protein"12663506
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AMD1 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to AMD1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AMD1 protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of AMD1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of AMD1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of AMD1 mRNA17585979
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of AMD1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AMD1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AMD1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AMD1 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMD1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of AMD1 mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AMD1 protein]26598702
D001280AtrazineAtrazine results in increased expression of AMD1 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AMD1 mRNA"19150397|2001819
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of AMD1 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of AMD1 mRNA24758408
C044887beta-methylcholinebeta-methylcholine affects the expression of AMD1 mRNA21179406
C053541bicalutamidebicalutamide results in increased expression of AMD1 mRNA15790403
C006780bisphenol Abisphenol A results in decreased expression of AMD1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of AMD1 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of AMD1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AMD1 mRNA27509014
C018021cobaltous chloridecobaltous chloride results in decreased expression of AMD1 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of AMD1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of AMD1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of AMD1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AMD1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of AMD1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of AMD1 mRNA19167446
D016572CyclosporineCyclosporine results in increased methylation of AMD1 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AMD1 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AMD1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AMD1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AMD1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of AMD1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AMD1 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of AMD1 mRNA26924002
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of AMD1 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of AMD1 mRNA21233418
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of AMD1 mRNA23649840
D018120FinasterideFinasteride results in increased expression of AMD1 mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of AMD1 mRNA18035473
D005485FlutamideFlutamide results in increased expression of AMD1 mRNA24136188
D005492Folic AcidFolic Acid results in increased activity of AMD1 protein17371283
D005492Folic AcidReserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein]17371283
D005557FormaldehydeFormaldehyde results in decreased expression of AMD1 mRNA23649840
D005839GentamicinsGentamicins results in decreased expression of AMD1 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AMD1 mRNA20044591|2117940
D007213IndomethacinIndomethacin results in decreased expression of AMD1 mRNA16984733
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AMD1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AMD1 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of AMD1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of AMD1 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of AMD1 mRNA"24972896
D008627Mercuric ChlorideMercuric Chloride affects the expression of AMD1 mRNA20353558
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AMD1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of AMD1 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AMD1 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of AMD1 mRNA"29244179
C051752nefazodonenefazodone results in increased expression of AMD1 mRNA24136188
D009532NickelNickel results in increased expression of AMD1 mRNA24768652|2558310
D009538NicotineNicotine results in increased expression of AMD1 mRNA16949557
C005290oxybenzoneoxybenzone results in decreased expression of AMD1 mRNA22721600
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AMD1 mRNA23978341
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AMD1 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of AMD1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of AMD1 mRNA17426115|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of AMD1 mRNA]20059764
D011700Putrescine[Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein17474863
D012110ReserpineReserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein]17371283
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of AMD1 mRNA19167446
C059514resveratrolresveratrol results in decreased activity of AMD1 protein12663506
C009250sevofluranesevoflurane affects the expression of AMD1 mRNA15967596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of AMD1 mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of AMD1 gene28589171
D013467Sulindac[Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein17474863
C061133tamibarotenetamibarotene results in decreased expression of AMD1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AMD1 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AMD1 mRNA19770486
D014212TretinoinTretinoin results in decreased expression of AMD1 mRNA15498508|1605412
C080163trovafloxacintrovafloxacin results in decreased expression of AMD1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of AMD1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of AMD1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AMD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004014adenosylmethionine decarboxylase activity-IBA21873635  
GO:0004014adenosylmethionine decarboxylase activity-TAS1917972  2460457  
GO:0019810putrescine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006557S-adenosylmethioninamine biosynthetic process-IEA-  
GO:0006595polyamine metabolic process-TAS-  
GO:0006597spermine biosynthetic process-IBA21873635  
GO:0008295spermidine biosynthetic process-IBA21873635  
GO:0046500S-adenosylmethionine metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29596588Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study. (2018 May 1)Saunier VJAMA Ophthalmol