Gene: GAS6

2621
AXLLG|AXSF
growth arrest specific 6
protein-coding
13q34
Ensembl:ENSG00000183087 MIM:600441 Vega:OTTHUMG00000017395 UniprotKB:Q14393
NG_029703.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.527e-1 (AD)  1.603e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPDC10.923
ATG4B0.922
RAB240.915
SCYL10.915
NDUFV10.913
CAPN10.911
GPS10.909
SGSM30.908
PHKG20.907
LRSAM10.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.718
OR4F29-0.689
MTRNR2L6-0.393
MTRNR2L10-0.376
MTRNR2L9-0.37
KCNJ15-0.328
KLRB1-0.307
MTRNR2L3-0.302
FOLR3-0.301
MTRNR2L1-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of GAS6 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GAS6 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GAS6 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of GAS6 mRNA"25710175
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of GAS6 mRNA23052194
C0194992-nitrofluorene2-nitrofluorene results in increased expression of GAS6 mRNA14600272|1589037
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAS6 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GAS6 mRNA14600272|1589037
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of GAS6 mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAS6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GAS6 mRNA17562736
D000244Adenosine DiphosphateGAS6 protein results in increased susceptibility to Adenosine Diphosphate15733062
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GAS6 mRNA14600272|1589037
D000450AldosteroneAldosterone results in increased expression of GAS6 protein19564549
D000450AldosteroneNR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]19564549
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]19564549
D013196DihydrotestosteroneAR mutant form inhibits the reaction [Dihydrotestosterone results in increased expression of GAS6 mRNA]20048160
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [AR protein binds to GAS6 promoter]20048160
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [EP300 protein binds to GAS6 promoter]20048160
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of GAS6 mRNA20048160
D013196DihydrotestosteroneFlutamide inhibits the reaction [Dihydrotestosterone results in increased expression of GAS6 mRNA]20048160
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors results in increased expression of GAS6 protein19126665
D001241AspirinGAS6 protein affects the susceptibility to Aspirin16999853
C547126AZM551248AZM551248 results in increased expression of GAS6 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GAS6 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GAS6 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GAS6 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of GAS6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of GAS6 gene25435355
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GAS6 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GAS6 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GAS6 mRNA22610609
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of GAS6 mRNA20660070
D004958EstradiolEstradiol results in increased expression of GAS6 mRNA19429434|2301914
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of GAS6 mRNA]19429434
D004958EstradiolEstradiol results in increased expression of GAS6 mRNA19484750
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of GAS6 mRNA17630414
C095105bexarotenebexarotene results in decreased expression of GAS6 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of GAS6 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of GAS6 mRNA18180321
C006780bisphenol Abisphenol A results in increased expression of GAS6 mRNA12075121
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of GAS6 mRNA28628672
D001761BleomycinBleomycin results in increased expression of GAS6 protein29175452
C032688boric acidboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]28285642
C018475butyraldehydebutyraldehyde results in decreased expression of GAS6 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GAS6 mRNA25993096
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GAS6 mRNA20360939
C459604candoxincandoxin results in increased expression of GAS6 mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GAS6 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GAS6 protein16799993
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GAS6 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GAS6 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GAS6 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of GAS6 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of GAS6 mRNA24386269
D005576ColforsinColforsin results in decreased expression of GAS6 mRNA15313392
D003300Copper[Disulfiram binds to Copper] which results in increased expression of GAS6 mRNA24690739
D003345CorticosteroneCorticosterone results in increased expression of GAS6 mRNA15755911
D003474CurcuminCurcumin results in increased expression of GAS6 mRNA21594647
D003609DactinomycinDactinomycin results in increased degradation of GAS6 mRNA20048160
D003609DactinomycinPhosphates promotes the reaction [Dactinomycin results in increased degradation of GAS6 mRNA]20048160
C014347decitabine[decitabine affects the methylation of GAS6 protein] which affects the expression of GAS6 mRNA18381416|1838141
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of GAS6 mRNA28628672
D003907Dexamethasoneboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]28285642
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein28285642
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GAS6 mRNA16054899
D003907Dexamethasonesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]28285642
D003976DiazinonDiazinon results in increased methylation of GAS6 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GAS6 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of GAS6 mRNA18457598
D004041Dietary FatsDietary Fats results in increased expression of GAS6 mRNA22609946
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GAS6 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of GAS6 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GAS6 mRNA20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GAS6 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GAS6 mRNA16636312
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GAS6 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GAS6 mRNA14600272|1589037
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of GAS6 mRNA24690739
D004237DiuronDiuron results in decreased expression of GAS6 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of GAS6 mRNA15033991
C070609EMD 53998EMD 53998 analog results in increased expression of GAS6 mRNA24977338
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of GAS6 protein17717130
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAS6 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GAS6 mRNA17557909
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GAS6 mRNA12075121|1735126
D005031EthylenethioureaEthylenethiourea results in decreased expression of GAS6 mRNA18801409
C082360fipronilfipronil results in decreased expression of GAS6 mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of GAS6 mRNA18035473
D005485FlutamideFlutamide inhibits the reaction [Dihydrotestosterone results in increased expression of GAS6 mRNA]20048160
D005485FlutamideFlutamide inhibits the reaction [Testosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 mRNA]]20048160
D005485FlutamideFlutamide inhibits the reaction [Testosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 protein]]20048160
D005485FlutamideFlutamide results in decreased expression of GAS6 mRNA24136188
D005492Folic AcidFolic Acid affects the expression of GAS6 mRNA17320366
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GAS6 gene20938992
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of GAS6 mRNA]19429434
C070081fulvestrantfulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of GAS6 mRNA]19429434
C070081fulvestrantfulvestrant inhibits the reaction [Tamoxifen results in increased expression of GAS6 mRNA]19429434
C039281furanfuran results in increased expression of GAS6 mRNA24183702
C039281furanfuran results in decreased expression of GAS6 mRNA25539665
D019833GenisteinGenistein results in increased expression of GAS6 mRNA23019147
D019833GenisteinGenistein results in increased expression of GAS6 mRNA12075121
D005897GlafenineGlafenine results in increased expression of GAS6 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of GAS6 mRNA22634610
D006861Hydrogen PeroxideGAS6 protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]15123721
D003900DesoxycorticosteroneGAS6 protein promotes the reaction [Desoxycorticosterone results in increased expression of IL6 protein]19564549
D003900DesoxycorticosteroneGAS6 protein promotes the reaction [Desoxycorticosterone results in increased expression of TNF protein]19564549
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of GAS6 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of GAS6 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of GAS6 mRNA28628672
D0150561-Methyl-3-isobutylxanthineboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]28285642
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein28285642
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GAS6 mRNA16054899
D0150561-Methyl-3-isobutylxanthinesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]28285642
C045463leflunomideleflunomide results in decreased expression of GAS6 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of GAS6 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GAS6 mRNA21039473
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GAS6 mRNA27339419
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GAS6 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GAS6 mRNA26378955
D008701MethapyrileneMethapyrilene results in increased expression of GAS6 mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GAS6 gene20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GAS6 mRNA24810058
D008777MethyltestosteroneMethyltestosterone results in increased expression of GAS6 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of GAS6 protein24625837
C523799MRK 003GAS6 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GAS6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GAS6 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GAS6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GAS6 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of GAS6 mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of GAS6 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of GAS6 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of GAS6 mRNA24136188
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of GAS6 protein17717130
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GAS6 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GAS6 mRNA25729387
C494474perchlorateperchlorate results in decreased expression of GAS6 mRNA18801409
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GAS6 mRNA18692542|1916217
D010634PhenobarbitalPhenobarbital affects the expression of GAS6 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GAS6 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GAS6 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GAS6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GAS6 mRNA26272509
D010710PhosphatesFlutamide inhibits the reaction [Testosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 mRNA]]20048160
D010710PhosphatesFlutamide inhibits the reaction [Testosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 protein]]20048160
D010710PhosphatesPhosphates promotes the reaction [Dactinomycin results in increased degradation of GAS6 mRNA]20048160
D010710PhosphatesPhosphates results in decreased expression of GAS6 mRNA20048160
D010710PhosphatesPhosphates results in decreased expression of GAS6 protein20048160
D010710PhosphatesTestosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 mRNA]20048160
D010710PhosphatesTestosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 protein]20048160
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of GAS6 mRNA15890375
C006253pirinixic acidpirinixic acid results in decreased expression of GAS6 mRNA23811191
C006253pirinixic acidpirinixic acid results in decreased expression of GAS6 mRNA15890375
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of GAS6 protein29175452
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GAS6 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of GAS6 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GAS6 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of GAS6 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of GAS6 mRNA22238285
D011374ProgesteroneProgesterone results in increased expression of GAS6 mRNA20726854
D020849Raloxifene Hydrochloridefulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of GAS6 mRNA]19429434
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of GAS6 mRNA19429434
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GAS6 mRNA16079270
C059514resveratrolresveratrol results in increased expression of GAS6 mRNA25905778
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GAS6 mRNA16054899
C010327salinomycinsalinomycin results in decreased expression of GAS6 mRNA19682730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GAS6 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of GAS6 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of GAS6 mRNA22714537
C538809sodium pentaboratesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of GAS6 protein]28285642
D018038Sodium SeleniteSodium Selenite results in increased expression of GAS6 mRNA18175754
D013148SpironolactoneSpironolactone affects the expression of GAS6 protein19564549
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]19564549
D013311StreptozocinStreptozocin results in increased expression of GAS6 protein12644472
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of GAS6 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GAS6 mRNA26378955
D013629Tamoxifenfulvestrant inhibits the reaction [Tamoxifen results in increased expression of GAS6 mRNA]19429434
D013629TamoxifenTamoxifen results in increased expression of GAS6 mRNA19429434
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of GAS6 mRNA17630414
C003377taxifolintaxifolin results in increased expression of GAS6 mRNA17541156
D013739TestosteroneFlutamide inhibits the reaction [Testosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 mRNA]]20048160
D013739TestosteroneFlutamide inhibits the reaction [Testosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 protein]]20048160
D013739TestosteroneTestosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 mRNA]20048160
D013739TestosteroneTestosterone inhibits the reaction [Phosphates results in decreased expression of GAS6 protein]20048160
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GAS6 mRNA]14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAS6 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAS6 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of GAS6 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GAS6 mRNA14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GAS6 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GAS6 mRNA21215274
C009495titanium dioxidetitanium dioxide affects the expression of GAS6 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GAS6 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GAS6 mRNA25729387
D019772TopotecanTopotecan results in increased expression of GAS6 mRNA25729387
D014212TretinoinTretinoin results in increased expression of GAS6 mRNA18230668
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GAS6 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of GAS6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GAS6 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of GAS6 gene29154799
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of GAS6 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of GAS6 mRNA19015723
D014812Vitamin KVitamin K results in increased activity of GAS6 protein19126665
D010837Vitamin K 1Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]27212383
D010837Vitamin K 1[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein27212383
D010837Vitamin K 1Vitamin K 1 results in increased secretion of GAS6 protein22290807
D024482Vitamin K 2Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]27212383
D014859WarfarinWarfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]26206560
D014859WarfarinWarfarin results in decreased carboxylation of GAS6 protein26206560
D014859WarfarinVitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein]27212383
D014859Warfarin[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein27212383
D014859WarfarinWarfarin results in decreased expression of GAS6 protein19564549
D014859WarfarinWarfarin results in decreased carboxylation of GAS6 protein18495950

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IDA21501828  
GO:0005102signaling receptor binding-IDA16359517  
GO:0005102signaling receptor binding-IPI7854420  
GO:0005245voltage-gated calcium channel activity-IDA18395422  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16362042  18760998  20088931  20103767  
GO:0030296protein tyrosine kinase activator activity-IDA20103767  
GO:0030971receptor tyrosine kinase binding-IPI7634325  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IDA16723520  
GO:0048018receptor ligand activity-IDA15184064  
GO:0060090molecular adaptor activity-IDA21501828  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0001934positive regulation of protein phosphorylation-IDA7854420  16723520  20103767  
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0001961positive regulation of cytokine-mediated signaling pathway-IMP18840707  
GO:0002576platelet degranulation-TAS-  
GO:0003104positive regulation of glomerular filtration-ISS-  
GO:0006468protein phosphorylation-IDA16359517  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0006909phagocytosis-IDA21501828  
GO:0006915apoptotic process-IEA-  
GO:0007050cell cycle arrest-TAS16564713  
GO:0007155cell adhesion-TAS16564713  
GO:0007165signal transduction-IDA7854420  18680538  
GO:0007165signal transduction-TAS16564713  
GO:0007167enzyme linked receptor protein signaling pathway-IEA-  
GO:0008283cell proliferation-TAS16564713  
GO:0009267cellular response to starvation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010628positive regulation of gene expression-IDA19657094  
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway-IDA19657094  
GO:0010934macrophage cytokine production-IEA-  
GO:0016477cell migration-TAS16564713  
GO:0018105peptidyl-serine phosphorylation-IDA18680538  20103767  
GO:0019064fusion of virus membrane with host plasma membrane-IDA21501828  
GO:0019079viral genome replication-IDA21501828  
GO:0030168platelet activation-TAS16564713  
GO:0031100animal organ regeneration-IEA-  
GO:0031589cell-substrate adhesion-IEA-  
GO:0032008positive regulation of TOR signaling-ISS-  
GO:0032148activation of protein kinase B activity-ISS-  
GO:0032689negative regulation of interferon-gamma production-IDA18840707  
GO:0032715negative regulation of interleukin-6 production-IDA19657094  
GO:0032720negative regulation of tumor necrosis factor production-IDA19657094  20103767  
GO:0032825positive regulation of natural killer cell differentiation-IDA18840707  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA16723520  
GO:0033159negative regulation of protein import into nucleus, translocation-IDA20103767  
GO:0035457cellular response to interferon-alpha-IDA19657094  
GO:0035690cellular response to drug-IDA16359517  
GO:0035754B cell chemotaxis-IDA19922767  
GO:0040008regulation of growth-IEA-  
GO:0043066negative regulation of apoptotic process-IDA19922767  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA16723520  
GO:0043277apoptotic cell clearance-IDA21501828  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA18680538  
GO:0043491protein kinase B signaling-IDA16723520  20103767  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045860positive regulation of protein kinase activity-IDA7854420  
GO:0045892negative regulation of transcription, DNA-templated-IDA18680538  
GO:0046718viral entry into host cell-IDA21501828  
GO:0046813receptor-mediated virion attachment to host cell-IDA21501828  
GO:0046827positive regulation of protein export from nucleus-IDA18680538  
GO:0048146positive regulation of fibroblast proliferation-IDA7854420  15184064  
GO:0050711negative regulation of interleukin-1 secretion-IDA20103767  
GO:0050766positive regulation of phagocytosis-IDA18395422  
GO:0050900leukocyte migration-TAS-  
GO:0051897positive regulation of protein kinase B signaling-IDA16359517  16723520  18680538  
GO:0061098positive regulation of protein tyrosine kinase activity-IDA20103767  
GO:0070168negative regulation of biomineral tissue development-IDA20048160  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA15184064  
GO:0070527platelet aggregation-TAS16564713  
GO:0070588calcium ion transmembrane transport-IDA18395422  
GO:0071307cellular response to vitamin K-IDA16359517  
GO:0071333cellular response to glucose stimulus-ISS-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0072659protein localization to plasma membrane-IDA16359517  
GO:0085029extracellular matrix assembly-ISS-  
GO:0097028dendritic cell differentiation-IEP19657094  
GO:0097241hematopoietic stem cell migration to bone marrow-IDA19922767  
GO:1900142negative regulation of oligodendrocyte apoptotic process-IDA16723520  
GO:1900165negative regulation of interleukin-6 secretion-IDA20103767  
GO:2000270negative regulation of fibroblast apoptotic process-IDA16359517  
GO:2000352negative regulation of endothelial cell apoptotic process-IDA16359517  18680538  18760998  
GO:2000510positive regulation of dendritic cell chemotaxis-IDA19657094  
GO:2000533negative regulation of renal albumin absorption-ISS-  
GO:2000669negative regulation of dendritic cell apoptotic process-IDA19657094  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA8336730  18395422  19922767  20088931  
GO:0005737cytoplasm-IDA18395422  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-159740Gamma-carboxylation of protein precursorsIEA
R-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusTAS
R-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteinsTAS
R-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsIEA
R-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationIEA
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23341490Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. (2013 Feb)Hsiao FCJ Clin Endocrinol Metab
25752901Growth arrest-specific 6 and cardiometabolic risk factors in patients with psoriasis. (2015 Apr)Sunbul MCardiovasc Ther
23372645Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers. (2013)Verdugo RAPLoS One