Gene info: ID 26227

Gene: PHGDH

GENE ID: 26227

Description: phosphoglycerate dehydrogenase

Gene type: protein-coding

Location: 1p12

dbXrefs: Ensembl:ENSG00000092621 MIM:606879 Vega:OTTHUMG00000012100 UniprotKB:O43175

RefSeq: NG_009188.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.367e-1 (AD) 9.836e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14476101	chr1:120255992	PHGDH		6.620e-9	Alcohol consumption per day	27843151
cg14476101	chr1:120255992	PHGDH		3.690e-10	Alcohol consumption der day	27843151
cg16246545	chr1:120255941	PHGDH		1.540e-12	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSRP1	0.889
IQCK	0.888
COMT	0.877
PSAT1	0.875
HTRA1	0.872
PLXNB1	0.871
PON2	0.869
DDR1	0.866
PTGDS	0.865
GPRC5B	0.863

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COL19A1	-0.487
KCNH1	-0.486
TRIM58	-0.474
HS6ST3	-0.472
KCNH5	-0.472
HRH2	-0.471
ARHGAP20	-0.471
CDH7	-0.47
OR4F5	-0.467
KCNS2	-0.466

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of PHGDH mRNA"	19162173
C118559	1-bromopropane	1-bromopropane results in increased expression of PHGDH protein	21925529
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of PHGDH mRNA"	21920950
C024709	2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone	"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to PHGDH protein"	16533022
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHGDH mRNA"	15215175
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of PHGDH mRNA	15890375
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PHGDH mRNA"	20959002
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to PHGDH protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PHGDH protein]	26598702
C027576	4-hydroxy-2-nonenal	PHGDH protein binds to 4-hydroxy-2-nonenal	20043646
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PHGDH mRNA	15890375
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of PHGDH mRNA"	28073004
D000082	Acetaminophen	Acetaminophen results in increased expression of PHGDH mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of PHGDH mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of PHGDH mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PHGDH protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PHGDH mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PHGDH mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PHGDH mRNA	15890375\|2363061
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of PHGDH mRNA	28522335
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of PHGDH mRNA	17023530
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PHGDH mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PHGDH protein]	26598702
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of PHGDH mRNA	19197388
D001379	Azathioprine	Azathioprine results in decreased expression of PHGDH mRNA	19192274
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PHGDH mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in increased expression of PHGDH protein	24464499
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PHGDH mRNA	19770486\|2261060
D004958	Estradiol	Estradiol affects the expression of PHGDH mRNA	22574217
D004958	Estradiol	Estradiol results in decreased expression of PHGDH mRNA	19484750
C044887	beta-methylcholine	beta-methylcholine affects the expression of PHGDH mRNA	21179406
C110172	BHTOH-QM	BHTOH-QM binds to PHGDH protein	16533022
C006780	bisphenol A	bisphenol A affects the expression of PHGDH mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PHGDH mRNA	20678512
C006780	bisphenol A	bisphenol A results in increased expression of PHGDH mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of PHGDH mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of PHGDH mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of PHGDH mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of PHGDH mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PHGDH mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PHGDH protein	21699967
C004656	chloroacetaldehyde	chloroacetaldehyde affects the expression of PHGDH mRNA	25596134
C007020	chlorophyllin	chlorophyllin analog results in decreased expression of PHGDH protein	22852132
C100187	chloropicrin	chloropicrin results in decreased expression of PHGDH mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PHGDH mRNA	20938992
C059262	cidofovir	cidofovir affects the expression of PHGDH mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of PHGDH mRNA	25596134
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PHGDH mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PHGDH mRNA	19376846
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PHGDH mRNA	19549813
D003375	Coumestrol	Coumestrol results in increased expression of PHGDH mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of PHGDH mRNA	27523638
D016572	Cyclosporine	Cyclosporine affects the expression of PHGDH mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of PHGDH mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine affects the expression of PHGDH mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of PHGDH mRNA	25596134
D013759	Dronabinol	Dronabinol results in increased expression of PHGDH protein	18584336
D013759	Dronabinol	Dronabinol results in increased expression of PHGDH mRNA	16616335
D003907	Dexamethasone	Dexamethasone results in decreased expression of PHGDH mRNA	25047013
D003907	Dexamethasone	Dexamethasone results in decreased expression of PHGDH mRNA	22733784
C016366	dibenzothiophene	dibenzothiophene results in increased expression of PHGDH mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PHGDH mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PHGDH mRNA	17379624
D002945	Cisplatin	Cisplatin promotes the reaction [Piroxicam results in decreased expression of PHGDH mRNA]	21858171
D002945	Cisplatin	Cisplatin results in decreased expression of PHGDH protein	20540955
D002945	Cisplatin	Cisplatin results in increased expression of PHGDH mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of PHGDH mRNA	22023808
D004041	Dietary Fats	Dietary Fats results in decreased expression of PHGDH mRNA	25016146
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PHGDH mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PHGDH mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PHGDH mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PHGDH mRNA	14648872
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PHGDH mRNA	15890375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PHGDH mRNA	15890375
D004280	Dobutamine	Dobutamine results in increased expression of PHGDH mRNA	12423672
D004317	Doxorubicin	Doxorubicin affects the expression of PHGDH protein	29385562
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PHGDH protein	23301498
D004837	Epinephrine	Epinephrine results in increased expression of PHGDH mRNA	12423672
D000431	Ethanol	Ethanol results in increased expression of PHGDH protein	20621659
D000431	Ethanol	Ethanol results in decreased expression of PHGDH mRNA	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PHGDH mRNA	16174780\|1755557
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHGDH mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PHGDH mRNA	17557909
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PHGDH mRNA	16174780
D005047	Etoposide	PHGDH protein affects the susceptibility to Etoposide	16217747
D015025	Zearalenone	[Zearalenone co-treated with CGA protein] results in increased expression of PHGDH protein	25058043
C540355	fenamidone	fenamidone results in increased expression of PHGDH mRNA	27029645
D011345	Fenofibrate	Fenofibrate results in increased expression of PHGDH mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in increased expression of PHGDH mRNA	25596134
D005411	Flame Retardants	Flame Retardants results in increased expression of PHGDH protein	18550172
C061365	flusilazole	flusilazole results in decreased expression of PHGDH mRNA	22382673
C061365	flusilazole	flusilazole results in increased expression of PHGDH mRNA	22382673
D005485	Flutamide	Flutamide results in increased expression of PHGDH mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PHGDH mRNA	20938992
C039281	furan	furan results in increased expression of PHGDH mRNA	25539665\|2619464
C039281	furan	furan results in increased methylation of PHGDH gene	22079235
D005897	Glafenine	Glafenine results in increased expression of PHGDH mRNA	24136188
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA	19192274
D017313	Fenretinide	Fenretinide results in decreased expression of PHGDH mRNA	28973697
D006820	Hyaluronic Acid	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PHGDH protein]	23178681
D006861	Hydrogen Peroxide	Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PHGDH protein]	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of PHGDH protein	23178681
C492448	ICG 001	ICG 001 results in increased expression of PHGDH mRNA	26191083
D007069	Ifosfamide	Ifosfamide results in increased expression of PHGDH mRNA	25596134
C020758	indium trichloride	indium trichloride results in decreased expression of PHGDH protein	19539025
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of PHGDH mRNA	21396975
D007213	Indomethacin	Indomethacin results in increased expression of PHGDH mRNA	16184411
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHGDH mRNA	25613284
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PHGDH mRNA	12057914
D008154	Lucanthone	Lucanthone results in decreased expression of PHGDH mRNA	21148553
D008687	Metformin	Metformin results in increased expression of PHGDH mRNA	25596134
D008694	Methamphetamine	Methamphetamine results in decreased expression of PHGDH protein	19826936
D008701	Methapyrilene	Methapyrilene results in increased expression of PHGDH mRNA	15890375\|2248451
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PHGDH mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of PHGDH mRNA	19192274
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PHGDH protein	25809596
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PHGDH mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of PHGDH mRNA	24810058
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of PHGDH mRNA	19192274
D015741	Metribolone	Metribolone results in decreased expression of PHGDH protein	17152098
D015741	Metribolone	Metribolone results in increased expression of PHGDH protein	17152098
D008942	Mitoxantrone	PHGDH protein affects the susceptibility to Mitoxantrone	16217747
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PHGDH mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PHGDH mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of PHGDH mRNA	24136188
C022838	nickel chloride	nickel chloride results in increased expression of PHGDH mRNA	24612858
C028007	nickel monoxide	nickel monoxide results in increased expression of PHGDH mRNA	19167457
D009538	Nicotine	Nicotine results in increased expression of PHGDH mRNA	23825647
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of PHGDH mRNA	17616710
C025256	nonylphenol	nonylphenol results in increased expression of PHGDH mRNA	22982499
D010100	Oxygen	Oxygen deficiency results in decreased expression of PHGDH mRNA	25596134
D017239	Paclitaxel	Paclitaxel results in decreased expression of PHGDH protein	21118710
D052638	Particulate Matter	Particulate Matter results in increased expression of PHGDH protein	17922515
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PHGDH protein	18550172
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PHGDH protein	19954255
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of PHGDH mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PHGDH mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PHGDH mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of PHGDH mRNA	18158353
C018637	phorone	phorone affects the expression of PHGDH mRNA	18198479
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of PHGDH mRNA	15890375
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PHGDH mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of PHGDH mRNA	15890375
D010894	Piroxicam	Cisplatin promotes the reaction [Piroxicam results in decreased expression of PHGDH mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of PHGDH mRNA	21858171
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of PHGDH protein	18563748
D011239	Prednisolone	Prednisolone results in decreased expression of PHGDH mRNA	19192274
D011374	Progesterone	Progesterone results in decreased expression of PHGDH mRNA	20631399\|2301818
D011374	Progesterone	Progesterone results in increased expression of PHGDH mRNA	23018184
D011374	Progesterone	Progesterone results in decreased expression of PHGDH mRNA	19690047
C100573	prostaglandin A1	prostaglandin A1 analog results in increased metabolism of PHGDH protein	19800325
D011748	Pyrogallol	Pyrogallol results in increased expression of PHGDH mRNA	20362636
D011748	Pyrogallol	Silymarin inhibits the reaction [Pyrogallol results in increased expression of PHGDH mRNA]	20362636
D011794	Quercetin	Quercetin results in decreased expression of PHGDH mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of PHGDH protein	14750173
D015474	Isotretinoin	Isotretinoin results in increased expression of PHGDH mRNA	20436886
C009166	retinol acetate	retinol acetate results in increased expression of PHGDH mRNA	16772331
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of PHGDH mRNA	23806026
D012834	Silver	Silver results in increased expression of PHGDH mRNA	26551752
D012838	Silymarin	Silymarin inhibits the reaction [Pyrogallol results in increased expression of PHGDH mRNA]	20362636
C009277	sodium arsenate	sodium arsenate results in decreased expression of PHGDH mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of PHGDH protein	21925251
C017947	sodium arsenite	sodium arsenite results in increased expression of PHGDH protein	21925251
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of PHGDH protein	28918527
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of PHGDH protein	27548804
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in increased expression of PHGDH protein	24464499
D013629	Tamoxifen	Tamoxifen affects the expression of PHGDH mRNA	17555576
D013726	Terbutaline	Terbutaline results in increased expression of PHGDH mRNA	12423672
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PHGDH mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PHGDH mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHGDH mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PHGDH promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PHGDH mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PHGDH mRNA	17942748\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PHGDH mRNA	20959002
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of PHGDH mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHGDH mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of PHGDH mRNA	22378314
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PHGDH mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of PHGDH mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of PHGDH mRNA	20133372
D014241	Trichloroethylene	Trichloroethylene results in increased expression of PHGDH mRNA	28973375
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PHGDH mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PHGDH mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of PHGDH mRNA	19140230
D014415	Tunicamycin	Tunicamycin results in increased expression of PHGDH mRNA	22378314
C406224	valdecoxib	valdecoxib results in increased expression of PHGDH mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PHGDH gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PHGDH mRNA	25596134\|2915479
D014635	Valproic Acid	Valproic Acid affects the expression of PHGDH mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of PHGDH protein	17922515
C025643	vinclozolin	vinclozolin affects the expression of PHGDH mRNA	23034163
D015032	Zinc	Zinc deficiency results in increased expression of PHGDH mRNA	22171008
C088658	zoledronic acid	zoledronic acid results in decreased expression of PHGDH mRNA	24714768\|2559613

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004617	phosphoglycerate dehydrogenase activity	-	IBA	21873635
GO:0004617	phosphoglycerate dehydrogenase activity	-	TAS	-
GO:0009055	electron transfer activity	-	TAS	8758134
GO:0030060	L-malate dehydrogenase activity	-	IEA	-
GO:0051287	NAD binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006541	glutamine metabolic process	-	IEA	-
GO:0006544	glycine metabolic process	-	IEA	-
GO:0006564	L-serine biosynthetic process	-	TAS	-
GO:0006566	threonine metabolic process	-	IEA	-
GO:0007420	brain development	-	TAS	8758134
GO:0009448	gamma-aminobutyric acid metabolic process	-	IEA	-
GO:0010468	regulation of gene expression	-	IEA	-
GO:0019530	taurine metabolic process	-	IEA	-
GO:0021510	spinal cord development	-	IEA	-
GO:0021782	glial cell development	-	IEA	-
GO:0021915	neural tube development	-	IEA	-
GO:0022900	electron transport chain	-	IEA	-
GO:0031175	neuron projection development	-	IEA	-
GO:0070314	G1 to G0 transition	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0043209	myelin sheath	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 20458337 23533145

KEGG ID	KEGG Term
hsa00260	Glycine, serine and threonine metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-977347	Serine biosynthesis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26110892	Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. (2015 Jul)	Aslibekyan S	Obesity (Silver Spring)