Gene: B3GAT3

26229
GLCATI|JDSCD|glcUAT-I
beta-1,3-glucuronyltransferase 3
protein-coding
11q12.3
Ensembl:ENSG00000149541 MIM:606374 Vega:OTTHUMG00000167685 UniprotKB:O94766
NG_031863.1
PubMed
0   ANCO-SNPs
ND
1   
2.839e-2 (AD)  1.761e-1 (ND)   (Frontal_Cortex)
1.680e-1 (AD)  6.100e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRPL380.948
THAP40.948
MRPS20.945
PTOV10.942
TMEM2050.937
RUVBL20.934
MRPS340.934
DDX490.933
CUTA0.931
RNF1670.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.76
OR4F29-0.705
PZP-0.399
HMCN1-0.377
KLRB1-0.37
CEACAM3-0.361
DNASE1L3-0.357
KLRF1-0.35
KCNJ15-0.349
IL18RAP-0.349

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03041UDP-alpha-D-glucuronic acidSmall Molecule2616-64-0ExperimentalTarget
DB03435Uridine-5'-DiphosphateSmall Molecule58-98-0ExperimentalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of B3GAT3 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of B3GAT3 mRNA22230336|2906747
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of B3GAT3 mRNA15894607
D001280AtrazineAtrazine results in increased expression of B3GAT3 mRNA25929836
C006780bisphenol Abisphenol A results in increased expression of B3GAT3 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of B3GAT3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of B3GAT3 gene28505145
D003931DiacetylDiacetyl results in decreased activity of B3GAT3 protein11986319
D003931DiacetylUridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]11986319
C018021cobaltous chloridecobaltous chloride results in decreased expression of B3GAT3 mRNA19376846
D005944GlucosamineGlucosamine inhibits the reaction [IL1B protein results in decreased activity of B3GAT3 protein]11229466
D005944GlucosamineGlucosamine inhibits the reaction [IL1B protein results in decreased expression of B3GAT3 mRNA]11229466
D005944GlucosamineGlucosamine results in increased expression of B3GAT3 mRNA11801247
D005944Glucosamine[XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucosamine results in increased expression of B3GAT3 mRNA]11801247
D005947GlucoseGlucose results in increased expression of B3GAT3 mRNA11801247
D005947GlucoseIL1B protein inhibits the reaction [Glucose results in increased expression of B3GAT3 mRNA]11801247
D005947Glucose[XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucose results in increased expression of B3GAT3 mRNA]11801247
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of B3GAT3 mRNA19376150
D019271Hypoxanthine[XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucosamine results in increased expression of B3GAT3 mRNA]11801247
D019271Hypoxanthine[XDH protein co-treated with Hypoxanthine] inhibits the reaction [Glucose results in increased expression of B3GAT3 mRNA]11801247
D048628KetolidesKetolides analog results in decreased expression of B3GAT3 mRNA24967691
D015735MifepristoneMifepristone results in decreased expression of B3GAT3 mRNA17584828
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of B3GAT3 mRNA"29244179
C006253pirinixic acidpirinixic acid results in increased expression of B3GAT3 mRNA18301758
D011794QuercetinQuercetin results in increased expression of B3GAT3 mRNA21632981
D012643SeleniumSelenium results in increased expression of B3GAT3 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of B3GAT3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of B3GAT3 mRNA28922406
D014050TolueneToluene results in decreased expression of B3GAT3 mRNA22967744
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of B3GAT3 mRNA15894607
D014535Uridine Diphosphate Glucuronic AcidB3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid11986319
D014535Uridine Diphosphate Glucuronic AcidUridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]11986319
D014635Valproic AcidValproic Acid results in increased expression of B3GAT3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of B3GAT3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of B3GAT3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24425863  
GO:0015018galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity-IBA21873635  
GO:0015018galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity-NAS10842173  
GO:0015018galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity-TAS-  
GO:0015020glucuronosyltransferase activity-IDA25893793  
GO:0015020glucuronosyltransferase activity-IMP21763480  
GO:0046872metal ion binding-IEA-  
GO:0072542protein phosphatase activator activity-IDA24425863  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IBA21873635  
GO:0006024glycosaminoglycan biosynthetic process-IDA24425863  
GO:0006024glycosaminoglycan biosynthetic process-IMP25893793  
GO:0006024glycosaminoglycan biosynthetic process-NAS10842173  
GO:0006486protein glycosylation-IEA-  
GO:0015012heparan sulfate proteoglycan biosynthetic process-IDA21763480  
GO:0015012heparan sulfate proteoglycan biosynthetic process-IMP25893793  
GO:0030203glycosaminoglycan metabolic process-TAS-  
GO:0043085positive regulation of catalytic activity-IDA24425863  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO:0050650chondroitin sulfate proteoglycan biosynthetic process-IBA21873635  
GO:0050650chondroitin sulfate proteoglycan biosynthetic process-IDA21763480  
GO:0050650chondroitin sulfate proteoglycan biosynthetic process-IMP25893793  
GO:0050651dermatan sulfate proteoglycan biosynthetic process-IDA21763480  
GO:0050651dermatan sulfate proteoglycan biosynthetic process-IMP25893793  
GO:0090316positive regulation of intracellular protein transport-IMP24425863  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IBA21873635  
GO:0000139Golgi membrane-TAS-  
GO:0005794Golgi apparatus-IDA21763480  
GO:0005801cis-Golgi network-IDA21763480  25893793  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-NAS10842173  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3560801Defective B3GAT3 causes JDSSDHDTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25821920Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking. (2015 Jun)Metzler-Guillemain CSyst Biol Reprod Med