Gene: GATA2

2624
DCML|IMD21|MONOMAC|NFE1B
GATA binding protein 2
protein-coding
3q21.3
Ensembl:ENSG00000179348 MIM:137295 Vega:OTTHUMG00000159689 UniprotKB:P23769
NG_029334.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.483e-1 (AD)  7.492e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC14A0.867
CARD100.863
ARHGEF150.857
FLI10.856
MECOM0.856
CD340.853
PALMD0.845
FLT40.844
FOXC10.838
LEF10.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.446
ASPDH-0.404
FAM43B-0.388
CRH-0.388
ATP2C2-0.363
CPLX3-0.357
BCL11A-0.355
FAM71E1-0.354
MYADML2-0.353
SMIM18-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of GATA2 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of GATA2 mRNA28329830
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GATA2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GATA2 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one affects the expression of GATA2 mRNA"24646949
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]"18450646
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]"18450646
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]"18450646
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]"18450646
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GATA2 mRNA17562736
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]22258452
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]22258452
C041524aluminum sulfatealuminum sulfate results in decreased expression of GATA2 mRNA15961160
D000638AmiodaroneAmiodarone results in decreased expression of GATA2 mRNA17991464
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GATA2 mRNA16483693
C006632arsenic trioxidearsenic trioxide affects the methylation of GATA2 promoter26046465
C006632arsenic trioxidearsenic trioxide results in increased expression of GATA2 protein16360329
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GATA2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GATA2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of GATA2 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GATA2 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of GATA2 mRNA26271895
C006780bisphenol Abisphenol A affects the methylation of GATA2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of GATA2 mRNA28657538
C006780bisphenol Abisphenol A results in decreased expression of GATA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GATA2 gene28505145
D002038BungarotoxinsBungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
D002038BungarotoxinsBungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]18450646
D002038BungarotoxinsBungarotoxins inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
D002038BungarotoxinsBungarotoxins inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
C018475butyraldehydebutyraldehyde results in increased expression of GATA2 mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of GATA2 mRNA14757314
D020148Butyric Acidchebulinic acid promotes the reaction [Butyric Acid results in increased expression of GATA2 mRNA]14769215
D020148Butyric Acidtellimagrandin I promotes the reaction [Butyric Acid results in increased expression of GATA2 mRNA]14757314
C584509C646 compoundC646 compound results in decreased expression of GATA2 mRNA26191083
C103481chebulinic acidchebulinic acid promotes the reaction [Butyric Acid results in increased expression of GATA2 mRNA]14769215
C103481chebulinic acidchebulinic acid results in increased expression of GATA2 mRNA14769215
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GATA2 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of GATA2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GATA2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GATA2 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of GATA2 mRNA27858113
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of GATA2 mRNA24690739
D003300CopperCopper deficiency results in increased expression of GATA2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of GATA2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GATA2 mRNA"19167446
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]22258452
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]22258452
D003474CurcuminCurcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]22258452
C017160cypermethrincypermethrin results in decreased expression of GATA2 mRNA22528246
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of GATA2 mRNA17185465
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of GATA2 mRNA26271895
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GATA2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GATA2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of GATA2 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of GATA2 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of GATA2 mRNA16002434
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of GATA2 mRNA24690739
C118739entinostatentinostat results in increased expression of GATA2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GATA2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GATA2 mRNA16174780
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GATA2 mRNA16174780
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of GATA2 mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of GATA2 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GATA2 gene20938992
C039281furanfuran results in increased expression of GATA2 mRNA27387713
D006427HeminHemin results in decreased expression of GATA2 mRNA21414390
D006427Heminhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]21414390
D006427Heminhydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]21414390
D006427HeminPhenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]21414390
D017313FenretinideFenretinide results in increased expression of GATA2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GATA2 mRNA21179406
C031927hydroquinonehydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]21414390
C031927hydroquinonehydroquinone results in decreased expression of GATA2 mRNA21414390
C013038hydroxyhydroquinonehydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]21414390
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of GATA2 mRNA21414390
C492448ICG 001ICG 001 results in decreased expression of GATA2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GATA2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GATA2 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of GATA2 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GATA2 mRNA"24972896
D008070Lipopolysaccharides2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
D008070LipopolysaccharidesGATA2 affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]23940812
D008070LipopolysaccharidesGATA2 affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]23940812
D008070LipopolysaccharidesLipopolysaccharides affects the localization of and results in increased activity of GATA2 protein23940812
D008070LipopolysaccharidesMYD88 affects the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
D008070LipopolysaccharidesTLR4 affects the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
C054474manumycinmanumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
C054474manumycinmanumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]18450646
C054474manumycinmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
C054474manumycinmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
C042720mercuric bromidemercuric bromide results in increased expression of GATA2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GATA2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GATA2 mRNA28001369
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of GATA2 mRNA"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of GATA2 mRNA"19615344
C523799MRK 003GATA2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GATA2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GATA2 mRNA"25554681
D009538Nicotine"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]"18450646
D009538Nicotine"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]"18450646
D009538NicotineBungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
D009538NicotineBungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
D009538NicotineCHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]18450646
D009538NicotineGATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]18450646
D009538NicotineGATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]18450646
D009538Nicotinemanumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
D009538Nicotinemanumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]18450646
D009538NicotineNicotine results in increased expression of GATA2 mRNA18450646
D009538NicotineNicotine results in increased expression of GATA2 protein18450646
D009538NicotineU 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
D009538NicotineU 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]18450646
C007350nitrofennitrofen results in decreased expression of GATA2 mRNA27592368
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GATA2 mRNA26272509
D019800PhenolPhenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]21414390
D019800PhenolPhenol results in decreased expression of GATA2 mRNA21414390
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GATA2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of GATA2 mRNA20707411
D059808PolyphenolsPolyphenols results in decreased expression of GATA2 mRNA16293270
C467566pomalidomidepomalidomide results in decreased expression of GATA2 mRNA15292067
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of GATA2 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of GATA2 mRNA23018184
D011374Progesterone[Progesterone results in increased activity of PGR protein] which results in increased expression of GATA2 mRNA15845616
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of GATA2 mRNA19429434
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]23940812
D012834SilverSilver results in increased expression of GATA2 mRNA26014281
C009277sodium arsenatesodium arsenate results in decreased expression of GATA2 mRNA16882884
C017947sodium arsenite"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of GATA2 mRNA"19615344
C017947sodium arsenitesodium arsenite results in decreased expression of GATA2 mRNA19615344
D053260SootSoot results in increased expression of GATA2 mRNA26551751
C061133tamibarotenetamibarotene results in decreased expression of GATA2 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of GATA2 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of GATA2 mRNA17555576
C087926tellimagrandin Itellimagrandin I promotes the reaction [Butyric Acid results in increased expression of GATA2 mRNA]14757314
C087926tellimagrandin Itellimagrandin I promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GATA2 mRNA]14757314
C087926tellimagrandin Itellimagrandin I results in increased expression of GATA2 mRNA14757314
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of GATA2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GATA2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GATA2 mRNA24058054
D013752TetracyclineTetracycline results in increased expression of GATA2 mRNA16917069
D013755Tetradecanoylphorbol Acetatetellimagrandin I promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GATA2 mRNA]14757314
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GATA2 mRNA14757314
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GATA2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of GATA2 mRNA22378314
C009495titanium dioxidetitanium dioxide affects the expression of GATA2 mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of GATA2 mRNA23557971
D014028Tobacco Smoke Pollution"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]"18450646
D014028Tobacco Smoke Pollution"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]"18450646
D014028Tobacco Smoke PollutionBungarotoxins inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
D014028Tobacco Smoke PollutionBungarotoxins inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
D014028Tobacco Smoke PollutionCHRNA7 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
D014028Tobacco Smoke PollutionGATA2 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 mRNA]18450646
D014028Tobacco Smoke PollutionGATA2 protein affects the reaction [Tobacco Smoke Pollution results in increased expression of CHRNA7 protein]18450646
D014028Tobacco Smoke Pollutionmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
D014028Tobacco Smoke Pollutionmanumycin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GATA2 mRNA18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GATA2 protein18450646
D014028Tobacco Smoke PollutionU 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
D014028Tobacco Smoke PollutionU 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GATA2 mRNA20133372
D014050TolueneToluene results in increased expression of GATA2 mRNA22967744
D014118Toxins, Biological"Toxins, Biological affects the expression of GATA2 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of GATA2 mRNA15498508
D014212TretinoinTretinoin results in decreased expression of GATA2 protein18922099
D014212TretinoinTretinoin results in increased expression of GATA2 mRNA17138961
D014241TrichloroethyleneTrichloroethylene results in increased expression of GATA2 mRNA15363585
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of GATA2 mRNA17185465
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GATA2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of GATA2 mRNA15901671
C057693troglitazonetroglitazone results in decreased expression of GATA2 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of GATA2 mRNA22378314
C113580U 0126U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]18450646
C113580U 0126U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]18450646
C113580U 0126U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 mRNA]18450646
C113580U 0126U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of GATA2 protein]18450646
D014520UrethaneUrethane results in increased expression of GATA2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of GATA2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of GATA2 mRNA15901671
C025643vinclozolinvinclozolin affects the expression of GATA2 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of GATA2 mRNA26682919
D015034Zinc OxideZinc Oxide analog results in decreased expression of GATA2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of GATA2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA27780851  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001158enhancer sequence-specific DNA binding-IDA19323994  
GO:0003682chromatin binding-IDA19242469  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA15016828  20206639  
GO:0005515protein binding-IPI7568177  10938104  16153155  18250304  20705609  21988832  
23887938  25416956  
GO:0008134transcription factor binding-IPI15016828  
GO:0008270zinc ion binding-IEA-  
GO:0070742C2H2 zinc finger domain binding-IPI12483298  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001655urogenital system development-IEA-  
GO:0001709cell fate determination-IEA-  
GO:0001764neuron migration-IEA-  
GO:0001892embryonic placenta development-IEA-  
GO:0006351transcription, DNA-templated-IDA16153155  
GO:0006909phagocytosis-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007507heart development-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0009887animal organ morphogenesis-IBA21873635  
GO:0009888tissue development-IBA21873635  
GO:0010628positive regulation of gene expression-IGI27780851  
GO:0010628positive regulation of gene expression-IMP27780851  
GO:0010629negative regulation of gene expression-IMP27780851  
GO:0010725regulation of primitive erythrocyte differentiation-IEA-  
GO:0021514ventral spinal cord interneuron differentiation-IEA-  
GO:0021533cell differentiation in hindbrain-IEA-  
GO:0021902commitment of neuronal cell to specific neuron type in forebrain-IEA-  
GO:0021954central nervous system neuron development-IEA-  
GO:0021983pituitary gland development-IEA-  
GO:0033993response to lipid-IEA-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035065regulation of histone acetylation-IEA-  
GO:0035854eosinophil fate commitment-IDA12045236  
GO:0042472inner ear morphogenesis-IEA-  
GO:0043306positive regulation of mast cell degranulation-IEA-  
GO:0045165cell fate commitment-IBA21873635  
GO:0045599negative regulation of fat cell differentiation-IMP20705609  
GO:0045648positive regulation of erythrocyte differentiation-IEA-  
GO:0045650negative regulation of macrophage differentiation-IEA-  
GO:0045654positive regulation of megakaryocyte differentiation-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IDA16672344  
GO:0045766positive regulation of angiogenesis-IDA19242469  
GO:0045766positive regulation of angiogenesis-IMP21788589  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15016828  20206639  21788589  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI19323994  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP19242469  
GO:0048468cell development-IBA21873635  
GO:0048469cell maturation-IEA-  
GO:0048565digestive tract development-IBA21873635  
GO:0048646anatomical structure formation involved in morphogenesis-IBA21873635  
GO:0048873homeostasis of number of cells within a tissue-IEA-  
GO:0050766positive regulation of phagocytosis-ISS-  
GO:0060100positive regulation of phagocytosis, engulfment-IEA-  
GO:0060216definitive hemopoiesis-IEA-  
GO:0060872semicircular canal development-IEA-  
GO:0061614pri-miRNA transcription by RNA polymerase II-IDA27780851  
GO:0070345negative regulation of fat cell proliferation-IMP20705609  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IMP27780851  
GO:0090102cochlea development-IEA-  
GO:0097154GABAergic neuron differentiation-IEA-  
GO:1902036regulation of hematopoietic stem cell differentiation-TAS-  
GO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IMP27780851  
GO:2000178negative regulation of neural precursor cell proliferation-IDA16672344  
GO:2000352negative regulation of endothelial cell apoptotic process-IMP21788589  
GO:2000977regulation of forebrain neuron differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA27780851  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA27780851  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19706030Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. (2009 Nov)Horne BDAnn Hum Genet