Gene: GATA4

2626
ASD2|TACHD|TOF|VSD1
GATA binding protein 4
protein-coding
8p23.1
Ensembl:ENSG00000136574 MIM:600576 Vega:OTTHUMG00000090800 UniprotKB:P43694
NG_008177.2
PubMed
0   ANCO-SNPs
ND|AD
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.270e-1 (AD)  4.493e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00412675chr8:11577758GATA4Gene body6.638e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB440.47
MYBPC30.455
CLEC17A0.45
LIPG0.449
S100A7A0.446
CLDN80.443
LCE1D0.443
TECRL0.438
OR52R10.437
KRTAP4-50.435

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYDC2-0.293
EIF1AY-0.26
TEX29-0.259
RPS4Y1-0.25
ZNF835-0.248
KNCN-0.245
HNF1A-0.241
KHDC1-0.24
CCDC74B-0.239
NLGN4Y-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA4 protein"23284745
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GATA4 mRNA28329830
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of GATA4 protein]11583584
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]]16109756|1808389
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]10788492
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]10788492
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GATA4 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GATA4 mRNA"21346803
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of GATA4 mRNA19643169
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GATA4 mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GATA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GATA4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GATA4 mRNA17562736
D019342Acetic AcidAcetic Acid results in decreased expression of GATA4 protein21296659
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GATA4 gene27153756
D000450AldosteroneAldosterone results in increased expression of GATA4 protein19966502
D006710HomocysteineHomocysteine results in decreased expression of GATA4 mRNA27203204
D006710HomocysteineHomocysteine results in decreased expression of GATA4 protein27203204
D006710HomocysteineParticulate Matter promotes the reaction [Homocysteine results in decreased expression of GATA4 protein]27203204
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GATA4 mRNA16483693
D001151ArsenicArsenic affects the methylation of GATA4 gene25304211
C015001arsenitearsenite results in increased methylation of GATA4 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GATA4 mRNA"17331233
D001205Ascorbic AcidAscorbic Acid results in increased expression of GATA4 mRNA12668514
D001280AtrazineAtrazine results in increased expression of GATA4 mRNA22372587
D001280AtrazineQuercetin inhibits the reaction [Atrazine results in increased expression of GATA4 mRNA]22372587
D001374AzacitidineAzacitidine results in increased expression of GATA4 mRNA18037191
D001374AzacitidineAzacitidine results in increased expression of GATA4 protein18037191
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of GATA4 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of GATA4 mRNA20064783
C006780bisphenol Abisphenol A affects the methylation of GATA4 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of GATA4 mRNA24090592
C006780bisphenol Abisphenol A results in decreased expression of GATA4 mRNA22718145
C006780bisphenol Abisphenol A results in increased expression of GATA4 mRNA25181051
C086232bosentanbosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]17974986
C086232bosentanbosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]17974986
C086232bosentanbosentan affects the activity of GATA4 protein21084678
D002220CarbamazepineCarbamazepine affects the expression of GATA4 mRNA24752500
D002248Carbon MonoxideCarbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein]18037988
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GATA4 mRNA17484886
C043211carvedilolcarvedilol results in decreased phosphorylation of GATA4 protein21472269
C469298CEP-11004CEP-11004 inhibits the reaction [EDN1 protein results in increased activity of GATA4 protein]20067472
D003474CurcuminCurcumin results in decreased expression of GATA4 mRNA27237783
D003474CurcuminCurcumin results in decreased expression of GATA4 protein27237783
D016572Cyclosporine"Cyclosporine promotes the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA]"16259952
D004008DiclofenacDiclofenac affects the expression of GATA4 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of GATA4 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GATA4 mRNA26219507|2706063
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of GATA4 mRNA21922642
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of GATA4 mRNA22105179
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of GATA4 mRNA22105179
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in increased expression of GATA4 mRNA22112501
C001082diphenylcresyl phosphatediphenylcresyl phosphate results in increased expression of GATA4 mRNA25661707
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]]16109756|1808389
D004317Doxorubicinbosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]17974986
D004317Doxorubicinbosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]17974986
D004317DoxorubicinCarbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein]18037988
D004317DoxorubicinCSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]17334414
D004317DoxorubicinDoxorubicin results in decreased activity of GATA4 protein18037988
D004317DoxorubicinDoxorubicin results in decreased expression of GATA4 mRNA17974986|1832177
D004317DoxorubicinDoxorubicin results in decreased expression of GATA4 protein16109756|1644973
D004317DoxorubicinEPO protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]16449733
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]16109756|1808389
D004317DoxorubicinTadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]20543097
D004317DoxorubicinTLR4 protein affects the reaction [Doxorubicin results in decreased expression of GATA4 protein]18321777
D004317DoxorubicinDoxorubicin results in decreased expression of GATA4 protein15767673|2253287
D004317DoxorubicinGATA4 protein results in decreased susceptibility to Doxorubicin22532871
D004656Enalapril[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein18820026
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GATA4 protein]19332462
D000431EthanolEthanol results in increased phosphorylation of GATA4 protein18377926|1933246
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GATA4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GATA4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GATA4 mRNA12655037
D011345FenofibrateFenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]22198280
D011345FenofibratePPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]22198280
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in decreased expression of GATA4 mRNA22406618
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GATA4 mRNA28329830
D005472FluorouracilFluorouracil affects the expression of GATA4 protein21296659
D004397FonofosFonofos results in increased methylation of GATA4 promoter22847954
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of GATA4 mRNA22634610
C010974glyphosateglyphosate results in increased expression of GATA4 mRNA17984146
D006493Heparin"Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein]"16259952
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GATA4 mRNA23562911
C056599icariinicariin results in increased expression of GATA4 mRNA16490167
C082359imidaclopridimidacloprid results in decreased expression of GATA4 mRNA27792329
C082359imidaclopridimidacloprid results in decreased expression of GATA4 protein27792329
D007213IndomethacinIndomethacin results in decreased expression of GATA4 mRNA28201806
C051890irinotecanirinotecan affects the expression of GATA4 mRNA20097248
D007545Isoproterenol[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA10710348
D007545IsoproterenolIsoproterenol promotes the reaction [NFATC1 protein binds to GATA4 protein]11435416
C037068latrunculin Blatrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]11739382
C005219methyl cellosolvemethyl cellosolve results in increased expression of GATA4 mRNA19643169
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GATA4 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of GATA4 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GATA4 protein26558463
D008790Metoprolol[Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein18820026
D008790MetoprololMetoprolol results in decreased phosphorylation of GATA4 protein21472269
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of GATA4 mRNA]27264040
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of GATA4 mRNA"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of GATA4 mRNA"19615344
D015544Inositol 1,4,5-Trisphosphate"Cyclosporine promotes the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA]"16259952
D015544Inositol 1,4,5-Trisphosphate"Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein]"16259952
D015544Inositol 1,4,5-Trisphosphate"Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA"16259952
D009538Nicotine[GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]24089524
D009538NicotineNicotine promotes the reaction [GATA4 protein binds to SP1 protein]24089524
D009538NicotineNicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]24089524
D009538NicotineNicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]24089524
C007350nitrofennitrofen results in decreased expression of GATA4 mRNA18280291|2342697
C007350nitrofennitrofen results in decreased expression of GATA4 protein23426975
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GATA4 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of GATA4 mRNA26272509
D010278ParathionParathion results in increased methylation of GATA4 promoter22847954
D052638Particulate MatterParticulate Matter promotes the reaction [Homocysteine results in decreased expression of GATA4 protein]27203204
D052638Particulate MatterParticulate Matter results in decreased expression of GATA4 mRNA27203204
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GATA4 mRNA23562911|2617826
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GATA4 protein26178269
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GATA4 mRNA23562911
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GATA4 mRNA16221955
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GATA4 mRNA23941634
D026023Permethrin[fluoranthene co-treated with Permethrin] results in decreased expression of GATA4 mRNA22406618
D026023PermethrinPermethrin results in increased expression of GATA4 mRNA22406618
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA4 protein"23284745
D010656PhenylephrineEP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]12724418
D010656Phenylephrine[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA10710348
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]10788492
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]10788492
D010656PhenylephrineGATA4 protein affects the susceptibility to Phenylephrine18252717
D010656Phenylephrinelatrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]11739382
D010656PhenylephrineMAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]10788492
D010656PhenylephrineMAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]10788492
D010656PhenylephrinePhenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]10788492
D010656PhenylephrinePhenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]15220332
D010656PhenylephrinePhenylephrine results in increased acetylation of GATA4 protein12724418
D010656PhenylephrinePhenylephrine results in increased activity of GATA4 protein11739382|1272441
D010656PhenylephrinePhenylephrine results in increased expression of GATA4 protein12724418|1996650
D010656PhenylephrinePhenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein10788492
D010656PhenylephrineY 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]11739382
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]15220332
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]15220332
C006253pirinixic acidpirinixic acid results in decreased expression of GATA4 mRNA20059764
C006253pirinixic acidpirinixic acid results in increased expression of GATA4 mRNA17951219
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of GATA4 mRNA]20059764
C006253pirinixic acidpirinixic acid results in increased expression of GATA4 mRNA19162173
C015476ponceau MXponceau MX results in decreased expression of GATA4 mRNA25727789
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of GATA4 mRNA]27264040
D011374ProgesteroneProgesterone results in decreased expression of GATA4 mRNA27264040
D015237DinoprostDinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]15271885
D015237DinoprostDinoprost results in increased activity of GATA4 protein15271885
D011748PyrogallolPyrogallol results in decreased expression of GATA4 mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in decreased expression of GATA4 mRNA]20362636
D011794QuercetinQuercetin inhibits the reaction [Atrazine results in increased expression of GATA4 mRNA]22372587
D000069458RanolazineRanolazine affects the expression of GATA4 protein18820026
D000069458Ranolazine[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein18820026
D000069458Ranolazine[Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein18820026
C093642SB 203580SB 203580 affects the activity of GATA4 protein21084678
C093642SB 203580SB 203580 inhibits the reaction [AGT protein modified form results in increased activity of GATA4 protein]21108934
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in decreased expression of GATA4 mRNA]20362636
C017947sodium arsenitesodium arsenite affects the methylation of GATA4 gene28589171
C017947sodium arsenite"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of GATA4 mRNA"19615344
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of GATA4 mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of GATA4 mRNA19615344
C105686SU 5402SU 5402 affects the expression of GATA4 mRNA15298682
D000068581TadalafilTadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]20543097
D013629TamoxifenTamoxifen results in decreased expression of GATA4 mRNA25123088
C012568terbufosterbufos results in increased methylation of GATA4 promoter22847954
C004648testosterone enanthatetestosterone enanthate affects the expression of GATA4 mRNA25603467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GATA4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GATA4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GATA4 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GATA4 mRNA20959002
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of GATA4 protein11583584
D013792ThalidomideThalidomide results in increased expression of GATA4 mRNA28892372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GATA4 mRNA27237783
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GATA4 protein27237783
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA4 protein"23284745
D014212TretinoinTretinoin results in increased expression of GATA4 mRNA16236135|1660451
D014212TretinoinTretinoin affects the expression of GATA4 mRNA16423341
C011559tributyltintributyltin results in increased expression of GATA4 mRNA27614199
C012589trichostatin Atrichostatin A results in decreased expression of GATA4 mRNA15901671
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GATA4 mRNA29024780
C113580U 0126U 0126 inhibits the reaction [AGT protein modified form results in increased activity of GATA4 protein]21108934
D014635Valproic AcidValproic Acid results in increased methylation of GATA4 gene28853863|2915479
D014635Valproic AcidValproic Acid results in increased expression of GATA4 mRNA27237783
D014635Valproic AcidValproic Acid results in increased expression of GATA4 protein27237783
D014635Valproic AcidValproic Acid results in decreased expression of GATA4 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GATA4 gene25560391
C025643vinclozolinvinclozolin results in increased expression of GATA4 mRNA20566332
D014810Vitamin EVitamin E affects the expression of GATA4 mRNA15370891
C108830Y 27632Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]11739382
D015032ZincZinc results in decreased expression of GATA4 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of GATA4 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IGI21330551  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IPI21330551  
GO:0001158enhancer sequence-specific DNA binding-IEA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IGI21330551  
GO:0003677DNA binding-IDA24000169  
GO:0003677DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activitycontributes_toIDA9312027  
GO:0003713transcription coactivator activity-IDA21220346  
GO:0005515protein binding-IPI9312027  12845333  15485867  16199874  17053787  21220346  
24000169  
GO:0008134transcription factor binding-IPI9858576  
GO:0008270zinc ion binding-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0033613activating transcription factor binding-ISS-  
GO:0043565sequence-specific DNA binding-ISS-  
GO:0044212transcription regulatory region DNA binding-IDA9566909  21220346  
GO:0051525NFAT protein binding-IEA-  
GO:0070410co-SMAD binding-IPI21330551  
GO ID GO Term Qualifier Evidence PubMed
GO:0001947heart looping-ISS-  
GO:0003180aortic valve morphogenesis-IMP29325903  
GO:0003197endocardial cushion development-IMP21330551  
GO:0003197endocardial cushion development-ISS-  
GO:0003208cardiac ventricle morphogenesis-TAS20347099  
GO:0003215cardiac right ventricle morphogenesis-ISS-  
GO:0003281ventricular septum development-ISS-  
GO:0003289atrial septum primum morphogenesis-ISS-  
GO:0003290atrial septum secundum morphogenesis-IMP20347099  
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0006366transcription by RNA polymerase II-ISS12845333  
GO:0007267cell-cell signaling-ISS-  
GO:0007492endoderm development-TAS20347099  
GO:0007507heart development-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0008584male gonad development-IEP17848411  
GO:0008584male gonad development-IMP21220346  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009887animal organ morphogenesis-IBA21873635  
GO:0009888tissue development-IBA21873635  
GO:0010507negative regulation of autophagy-IEA-  
GO:0010575positive regulation of vascular endothelial growth factor production-ISS-  
GO:0030513positive regulation of BMP signaling pathway-IEA-  
GO:0033189response to vitamin A-IEA-  
GO:0035054embryonic heart tube anterior/posterior pattern specification-ISS-  
GO:0042493response to drug-IMP20585342  
GO:0045165cell fate commitment-IBA21873635  
GO:0045766positive regulation of angiogenesis-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA24000169  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA21330551  29325903  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048468cell development-IBA21873635  
GO:0048565digestive tract development-IBA21873635  
GO:0048617embryonic foregut morphogenesis-ISS-  
GO:0048646anatomical structure formation involved in morphogenesis-IBA21873635  
GO:0051891positive regulation of cardioblast differentiation-ISS-  
GO:0060290transdifferentiation-IEA-  
GO:0060413atrial septum morphogenesis-IMP12845333  
GO:0060575intestinal epithelial cell differentiation-IDA9566909  
GO:0061049cell growth involved in cardiac muscle cell development-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0086004regulation of cardiac muscle cell contraction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9566909  21220346  24000169  
GO:0005634nucleus-ISS-  
GO:0005634nucleus-NAS12845333  
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
GO:0090575RNA polymerase II transcription factor complex-IDA9312027  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-397014Muscle contractionTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)TAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578768Physiological factorsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res
27374936Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4. (2016 Aug)Degenhardt FAlcohol Clin Exp Res
20585342Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. (2011 Oct)Kiefer FPharmacogenomics J
14581353Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. (2003 Oct 15)Miller CTClin Cancer Res
27237783Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. (2016 May 16)Cheng WToxicology
24314346Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. (2014 May 15)Jorde ABiol Psychiatry
23467912Cardiomyocyte differentiation of perinatallyderived mesenchymal stem cells. (2013 May)Nartprayut KMol Med Rep
22862823Association of GATA4 sequence variation with alcohol dependence. (2014 Mar)Karpyak VMAddict Biol
28111280Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. (2017 Feb 14)Jiang XYStem Cell Reports
24089524Nicotine induces the up-regulation of the alpha7-nicotinic receptor (alpha7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway. (2013 Nov 15)Brown KCJ Biol Chem
27397865GATA4 variant interaction with brain limbic structure and relapse risk: A voxel-based morphometry study. (2016 Sep)Zois EEur Neuropsychopharmacol
19332462Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. (2009 Apr 14)Doser TACirculation
28441648The Epigenetic Regulation of GATA4-Dependent Brain Natriuretic Peptide Expression during Alcohol Withdrawal. (2016)Glahn ANeuropsychobiology