Gene: GATA6

2627
-
GATA binding protein 6
protein-coding
18q11.2
Ensembl:ENSG00000141448 MIM:601656 Vega:OTTHUMG00000131767 UniprotKB:Q92908
NG_032677.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.281e-1 (AD)  4.719e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRABD2B0.914
SLC22A80.907
SLC22A20.9
ALX40.898
OR51E10.897
CDC20B0.889
SLC13A40.863
BMX0.861
MYOCD0.849
PTGDR0.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNPLA7-0.271
FEZF2-0.269
NDP-0.257
GRM3-0.247
KIAA0930-0.244
C2orf72-0.242
SORCS2-0.24
PTCHD1-0.237
ADORA1-0.236
ZNF285-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione affects the expression of GATA6 mRNA"19162173
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA6 protein"23284745
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GATA6 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GATA6 mRNA"19114083
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of GATA6 mRNA19643169
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GATA6 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GATA6 mRNA"20959002
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of GATA6 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of GATA6 mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of GATA6 mRNA17034753
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GATA6 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of GATA6 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of GATA6 mRNA17585979
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GATA6 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GATA6 mRNA]17585979
D019342Acetic AcidAcetic Acid results in decreased expression of GATA6 protein21296659
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GATA6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GATA6 gene27153756
C103303alitretinoinalitretinoin results in increased expression of GATA6 mRNA17034753
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GATA6 mRNA16483693
D000735AndrostenedioneFSHB protein promotes the reaction [[[GATA6 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Androstenedione]22155568
D000735AndrostenedioneFSHB protein promotes the reaction [[[GATA6 protein binds to STAR promoter] which results in increased expression of STAR mRNA] which results in increased abundance of Androstenedione]22155568
C004984apocarotenalapocarotenal results in increased expression of GATA6 mRNA17034753
C015001arsenitearsenite results in increased methylation of GATA6 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GATA6 mRNA"18687144
D001554BenzeneBenzene results in decreased expression of GATA6 mRNA15120971|1512265
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of GATA6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GATA6 mRNA21632981|2623829
D019207beta Carotenebeta Carotene results in increased expression of GATA6 mRNA17034753
C006780bisphenol Abisphenol A affects the methylation of GATA6 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of GATA6 mRNA22687993
C006780bisphenol Abisphenol A affects the expression of GATA6 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GATA6 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of GATA6 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of GATA6 protein21296659
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GATA6 mRNA15336504
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GATA6 mRNA12634122
D000068579CelecoxibCelecoxib results in decreased expression of GATA6 mRNA28201806
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of GATA6 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GATA6 gene20938992
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GATA6 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GATA6 mRNA12634122
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GATA6 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of GATA6 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GATA6 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of GATA6 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of GATA6 mRNA19376846
D016572CyclosporineCyclosporine results in decreased expression of GATA6 mRNA21632981|2556210
D003976DiazinonDiazinon results in increased methylation of GATA6 gene22964155
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GATA6 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GATA6 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GATA6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GATA6 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of GATA6 mRNA26934552
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GATA6 promoter23359474
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of GATA6 mRNA16507463
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of GATA6 mRNA22105179
D005038EthylnitrosoureaEthylnitrosourea promotes the reaction [GATA6 protein binds to KRAS exon]16271038
D005038EthylnitrosoureaEthylnitrosourea results in increased activity of GATA6 protein16271038
D005419FlavonoidsFlavonoids results in increased expression of GATA6 mRNA18035473
D005472FluorouracilFluorouracil affects the expression of GATA6 protein21296659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GATA6 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of GATA6 mRNA20655997
D005839GentamicinsGentamicins results in decreased expression of GATA6 mRNA22061828
C082359imidaclopridimidacloprid results in decreased expression of GATA6 protein27792329
D007213IndomethacinIndomethacin results in increased expression of GATA6 mRNA16984733
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GATA6 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GATA6 mRNA27392435
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GATA6 mRNA12634122
C045463leflunomideleflunomide results in decreased expression of GATA6 mRNA24136188
C042720mercuric bromidemercuric bromide results in increased expression of GATA6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of GATA6 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GATA6 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of GATA6 mRNA19643169
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [GATA6 protein binds to KRAS exon]16271038
D008748MethylcholanthreneMethylcholanthrene results in increased activity of GATA6 protein16271038
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GATA6 mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GATA6 mRNA23179753
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]"20230807
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of GATA6 mRNA16507463
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideGATA6 protein inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ALOX15 protein]11861401
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of GATA6 protein11861401
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GATA6 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GATA6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GATA6 mRNA"25620056
D009532NickelNickel results in decreased expression of GATA6 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of GATA6 mRNA17312168
D009538Nicotine[GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]24089524
D009538NicotineNicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]24089524
D009538NicotineNicotine promotes the reaction [GATA6 protein binds to SP1 protein]24089524
D009538NicotineNicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]24089524
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]"20230807
C012655nimesulidenimesulide results in decreased expression of GATA6 mRNA24136188
C007350nitrofennitrofen results in decreased expression of GATA6 mRNA17270562|1828029
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of GATA6 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GATA6 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GATA6 mRNA18804290
D010634PhenobarbitalPhenobarbital affects the expression of GATA6 mRNA19159669
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA6 protein"23284745
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GATA6 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of GATA6 mRNA18301758
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of GATA6 mRNA24583197
D011374ProgesteroneFSHB protein promotes the reaction [[[GATA6 protein binds to CYP17A1 promoter] which results in increased expression of CYP17A1 mRNA] which results in increased abundance of Progesterone]22155568
D011374ProgesteroneFSHB protein promotes the reaction [[[GATA6 protein binds to STAR promoter] which results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]22155568
D011374ProgesteroneProgesterone results in increased expression of GATA6 mRNA21540246
D011794QuercetinQuercetin results in increased expression of GATA6 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of GATA6 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GATA6 mRNA25895662
D012834SilverSilver results in increased expression of GATA6 mRNA28959546
D012834SilverSilver results in increased expression of GATA6 mRNA27131904
D019821SimvastatinSimvastatin results in increased expression of GATA6 mRNA19842842
D019821SimvastatinSimvastatin results in increased expression of GATA6 protein19842842
D012906SmokeSmoke affects the expression of GATA6 mRNA23693141
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GATA6 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of GATA6 mRNA16507463
C025463sulindac sulfoneGATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]11861401
C025463sulindac sulfonesulindac sulfone results in decreased expression of GATA6 protein11861401
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GATA6 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GATA6 mRNA19933214|2188995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GATA6 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GATA6 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GATA6 mRNA20959002
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GATA6 mRNA28065790
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of GATA6 protein"23284745
D014212TretinoinTretinoin results in increased expression of GATA6 mRNA17034753|1713896
D014212TretinoinTretinoin results in increased expression of GATA6 mRNA16236135|1660451
D014212TretinoinTretinoin results in increased expression of GATA6 mRNA20488242
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GATA6 mRNA19042947
D014501UraniumUranium analog results in decreased expression of GATA6 mRNA27544493
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GATA6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GATA6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GATA6 mRNA24383497|2627250
C066075vanadium pentoxidevanadium pentoxide affects the expression of GATA6 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GATA6 gene25560391
C025643vinclozolinvinclozolin affects the expression of GATA6 mRNA19015723
D014801Vitamin AVitamin A results in increased expression of GATA6 mRNA17034753
D002762CholecalciferolCholecalciferol results in increased expression of GATA6 mRNA17170073
D024483Vitamin K 3Vitamin K 3 affects the expression of GATA6 mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of GATA6 mRNA18593933
D015032ZincZinc results in increased expression of GATA6 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of GATA6 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IMP21127043  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001103RNA polymerase II repressing transcription factor binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA19666519  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI11889139  16199874  
GO:0008134transcription factor binding-IPI14988427  15016828  
GO:0008270zinc ion binding-IEA-  
GO:0019901protein kinase binding-IPI20864106  
GO:0044212transcription regulatory region DNA binding-IDA9566909  18177748  19666519  20206639  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA18177748  
GO:0001701in utero embryonic development-IEA-  
GO:0001889liver development-IEA-  
GO:0003148outflow tract septum morphogenesis-IMP19666519  
GO:0003309type B pancreatic cell differentiation-IEA-  
GO:0003310pancreatic A cell differentiation-IEA-  
GO:0006366transcription by RNA polymerase II-IDA19666519  
GO:0006644phospholipid metabolic process-IEA-  
GO:0007493endodermal cell fate determination-IEA-  
GO:0007507heart development-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0008584male gonad development-IEP17848411  
GO:0009887animal organ morphogenesis-IBA21873635  
GO:0009888tissue development-IBA21873635  
GO:0014898cardiac muscle hypertrophy in response to stress-IEA-  
GO:0030513positive regulation of BMP signaling pathway-IBA21873635  
GO:0032911negative regulation of transforming growth factor beta1 production-IMP21127043  
GO:0032912negative regulation of transforming growth factor beta2 production-IMP21127043  
GO:0035239tube morphogenesis-IEA-  
GO:0042493response to drug-IMP18671946  
GO:0043066negative regulation of apoptotic process-IMP21127043  
GO:0043627response to estrogen-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045165cell fate commitment-IBA21873635  
GO:0045766positive regulation of angiogenesis-IDA21127043  
GO:0045892negative regulation of transcription, DNA-templated-IDA18177748  
GO:0045893positive regulation of transcription, DNA-templated-IMP22750565  22824924  27756709  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048468cell development-IBA21873635  
GO:0048565digestive tract development-IBA21873635  
GO:0048645animal organ formation-IEA-  
GO:0048646anatomical structure formation involved in morphogenesis-IBA21873635  
GO:0051145smooth muscle cell differentiation-IMP17626241  
GO:0051891positive regulation of cardioblast differentiation-IEA-  
GO:0055007cardiac muscle cell differentiation-IEA-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060430lung saccule development-IEA-  
GO:0060486Clara cell differentiation-IEA-  
GO:0060510type II pneumocyte differentiation-IEA-  
GO:0060575intestinal epithelial cell differentiation-IDA9566909  
GO:0060947cardiac vascular smooth muscle cell differentiation-IMP11889139  12615657  
GO:0070848response to growth factor-IDA21127043  
GO:0071158positive regulation of cell cycle arrest-IDA9593712  
GO:0071371cellular response to gonadotropin stimulus-IEA-  
GO:0071456cellular response to hypoxia-IDA21127043  
GO:0071773cellular response to BMP stimulus-IEA-  
GO:0110024positive regulation of cardiac muscle myoblast proliferation-IDA25068583  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9566909  9593712  17785913  19666519  20206639  21127043  21828274  27756709  
GO:0005654nucleoplasm-TAS-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24089524Nicotine induces the up-regulation of the alpha7-nicotinic receptor (alpha7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway. (2013 Nov 15)Brown KCJ Biol Chem
29429410The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. (2018 Feb 12)Johnston ZCBMC Med
25127677Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice. (2014 Nov)Hermann PCGastroenterology