Gene: VPS33B

26276
-
VPS33B, late endosome and lysosome associated
protein-coding
15q26.1
Ensembl:ENSG00000184056 MIM:608552 Vega:OTTHUMG00000149835 UniprotKB:Q9H267
NG_012162.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.852e-2 (AD)  6.141e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8026678chr15:91018775 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs3743445chr15:91017952 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COG10.954
GPHN0.947
C16orf580.946
MRPS270.946
NDUFA100.944
AGK0.943
ABCF30.943
DHDDS0.941
UQCC10.939
COPG10.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.52
OR4F29-0.479
MTRNR2L6-0.475
MTRNR2L9-0.469
MTRNR2L10-0.439
RAI14-0.412
YES1-0.404
HEY2-0.403
MTRNR2L8-0.395
MTRNR2L2-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of VPS33B mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of VPS33B mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of VPS33B mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of VPS33B mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of VPS33B mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VPS33B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of VPS33B mRNA24449571
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of VPS33B mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of VPS33B mRNA25181051
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of VPS33B mRNA]20371981
D002220CarbamazepineCarbamazepine affects the expression of VPS33B mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of VPS33B mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of VPS33B mRNA17361019
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of VPS33B mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of VPS33B mRNA26924002
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of VPS33B mRNA22079256
D000431EthanolEthanol results in decreased expression of VPS33B mRNA29018328
D000431EthanolEthanol results in decreased expression of VPS33B mRNA17920746
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of VPS33B mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of VPS33B mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of VPS33B mRNA23649840
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of VPS33B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VPS33B mRNA"20188158
C523184mocetinostatmocetinostat results in decreased expression of VPS33B mRNA27255383
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VPS33B mRNA"12756304
D010634PhenobarbitalPhenobarbital results in decreased expression of VPS33B mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of VPS33B mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of VPS33B mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of VPS33B mRNA22079256
C010313pseudocumenepseudocumene results in decreased expression of VPS33B protein17337753
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of VPS33B mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VPS33B mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of VPS33B mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of VPS33B gene25560391
C025643vinclozolinvinclozolin results in decreased expression of VPS33B mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of VPS33B mRNA23869203
D019287Zinc SulfateZinc Sulfate results in increased expression of VPS33B mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  18474358  19109425  20190753  22677173  23901104  
23918659  25416956  25783203  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0006904vesicle docking involved in exocytosis-IEA-  
GO:0007032endosome organization-IMP23918659  
GO:0008333endosome to lysosome transportNOTIMP25783203  
GO:0015031protein transport-IMP15052268  
GO:0016192vesicle-mediated transport-IDA15790593  
GO:0017185peptidyl-lysine hydroxylation-IMP27435297  
GO:0032400melanosome localization-IDA15790593  
GO:0032418lysosome localization-IDA15790593  
GO:0032963collagen metabolic process-IMP27435297  
GO:0061025membrane fusion-IMP15052268  
GO:0070889platelet alpha granule organization-IMP16123220  
GO:0097352autophagosome maturationNOTIMP25783203  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15052268  20190753  
GO:0005764lysosome-IDA15052268  
GO:0005765lysosomal membrane-IEA-  
GO:0005770late endosome-IDA15052268  
GO:0005794Golgi apparatus-IDA27435297  
GO:0030123AP-3 adaptor complexcolocalizes_withIDA21411634  
GO:0030136clathrin-coated vesicle-IDA21411634  
GO:0030897HOPS complexNOTIDA25783203  
GO:0030897HOPS complexcolocalizes_withIDA19109425  
GO:0031091platelet alpha granule-IDA16123220  
GO:0031901early endosome membrane-IDA21411634  
GO:0031902late endosome membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA19109425  
GO:0055037recycling endosome-IEA-  
GO:0071439clathrin complexcolocalizes_withIDA21411634  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal