Gene: TINF2

26277
DKCA3|TIN2
TERF1 interacting nuclear factor 2
protein-coding
14q12
Ensembl:ENSG00000092330 MIM:604319 Vega:OTTHUMG00000171849 UniprotKB:Q9BSI4
NG_016650.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.790e-2 (AD)  7.376e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF4A10.919
ILF20.914
EIF4A30.913
KDELR20.911
SEC130.906
IMPDH20.905
EIF3D0.9
CAP10.899
USP390.898
RAB7A0.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.76
OR4F29-0.725
MTRNR2L6-0.264
MTRNR2L9-0.236
MTRNR2L10-0.19
HMHB1-0.187
CYP11B2-0.173
PRDM14-0.173
RAX2-0.164
OR6C74-0.162

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TINF2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TINF2 mRNA"21346803
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of TINF2 mRNA21731707
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TINF2 mRNA24449571
D001280AtrazineAtrazine results in increased expression of TINF2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of TINF2 mRNA22378314
D001554BenzeneBenzene results in increased expression of TINF2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TINF2 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of TINF2 mRNA19371625
C006780bisphenol Abisphenol A affects the methylation of TINF2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of TINF2 mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of TINF2 mRNA15878706
C584509C646 compoundC646 compound results in increased expression of TINF2 mRNA26191083
D002104CadmiumCadmium results in increased expression of TINF2 mRNA23369406
D019256Cadmium ChlorideCadmium Chloride affects the expression of TINF2 mRNA22110744
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TINF2 mRNA17484886
C014347decitabinedecitabine affects the expression of TINF2 mRNA23300844
D003976DiazinonDiazinon results in increased methylation of TINF2 gene22964155
D002945CisplatinCisplatin affects the expression of TINF2 mRNA23300844
D002945CisplatinCisplatin results in increased expression of TINF2 mRNA27392435
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of TINF2 mRNA25198161
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TINF2 mRNA22079256
D015025ZearalenoneZearalenone results in decreased expression of TINF2 mRNA19371625
C082360fipronilfipronil results in increased expression of TINF2 mRNA23962444
D005472FluorouracilFluorouracil results in decreased expression of TINF2 mRNA19272435
D005485FlutamideFlutamide results in increased expression of TINF2 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of TINF2 mRNA19167457
D019833GenisteinGenistein results in decreased expression of TINF2 mRNA19371625
C492448ICG 001ICG 001 results in increased expression of TINF2 mRNA26191083
C544151jinfukangjinfukang results in increased expression of TINF2 mRNA27392435
D007854LeadLead results in decreased expression of TINF2 mRNA19921347
C045463leflunomideleflunomide results in increased expression of TINF2 mRNA24136188
C066851mithramycin Amithramycin A inhibits the reaction [[SP1 protein binds to TINF2 promoter] which results in increased expression of TINF2 mRNA]21731707|2173170
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TINF2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of TINF2 mRNA19167457
C012655nimesulidenimesulide results in increased expression of TINF2 mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in increased expression of TINF2 mRNA15878706
C006253pirinixic acidpirinixic acid results in increased expression of TINF2 mRNA25270620
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TINF2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TINF2 mRNA22079256
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in decreased expression of TINF2 mRNA21731707
C059514resveratrolresveratrol results in decreased expression of TINF2 mRNA19371625
C017947sodium arsenitesodium arsenite results in increased expression of TINF2 mRNA17879257
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of TINF2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TINF2 mRNA19770486
D014204Trenbolone AcetateTrenbolone Acetate results in increased expression of TINF2 mRNA25198161
C057693troglitazonetroglitazone results in increased expression of TINF2 mRNA19140230
D014415TunicamycinTunicamycin results in increased expression of TINF2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of TINF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TINF2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TINF2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TINF2 mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of TINF2 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA bindingNOTIDA10581025  
GO:0005515protein binding-IPI11701125  12768206  15133513  15181449  15231715  15380063  
15383534  16169070  16880378  17589526  18202258  19287395  
19487455  21044950  25172512  25416956  25620558  25910212  
26496610  
GO:0042162telomeric DNA binding-IDA12768206  23685356  
GO ID GO Term Qualifier Evidence PubMed
GO:0010836negative regulation of protein ADP-ribosylation-IDA15133513  
GO:0016233telomere capping-IC15133513  
GO:0016233telomere capping-IMP18443218  
GO:0016233telomere capping-TAS-  
GO:0032202telomere assembly-IMP16880378  
GO:0032211negative regulation of telomere maintenance via telomerase-IGI10581025  
GO:0032211negative regulation of telomere maintenance via telomerase-IMP15133513  
GO:0050680negative regulation of epithelial cell proliferation-IMP15741234  
GO:0070198protein localization to chromosome, telomeric region-IMP15133513  18443218  
GO:1904356regulation of telomere maintenance via telomere lengthening-IMP18669893  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IDA10581025  12768206  
GO:0000783nuclear telomere cap complex-IDA16880378  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric region-IDA15133513  15380063  23685356  24270157  
GO:0005654nucleoplasm-TAS-  
GO:0010370perinucleolar chromocenter-IDA15741234  
GO:0016363nuclear matrix-IEA-  
GO:0016604nuclear body-IDA-  
GO:0070187shelterin complex-IDA15383534  23685356  
GO:0070187shelterin complex-IMP21852327  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-171306Packaging Of Telomere EndsTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301779Dyskeratosis Congenita (1993)Savage SA-