Gene: SACS

26278
ARSACS|DNAJC29|PPP1R138|SPAX6
sacsin molecular chaperone
protein-coding
13q12.12
Ensembl:ENSG00000151835 MIM:604490 Vega:OTTHUMG00000016562 UniprotKB:Q9NZJ4
NG_012342.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.790e-2 (AD)  9.045e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17078717chr13:23410292 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17078678chr13:23383375 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNJ10.951
UBR30.95
WDR470.948
ARFGEF20.943
PIK3CB0.943
CAND10.942
CHIC10.942
DMXL20.942
FAM126B0.942
PDS5B0.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.523
MYL3-0.451
RAB13-0.448
OR4F5-0.439
RNF135-0.439
COPZ2-0.437
FLT3LG-0.423
PDZK1IP1-0.422
TFPI2-0.421
MTRNR2L10-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of SACS mRNA19041380
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SACS mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SACS mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SACS mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SACS mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SACS mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of SACS mRNA"20406850
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SACS mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of SACS mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SACS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SACS mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SACS mRNA19770486
C006632arsenic trioxidearsenic trioxide results in increased expression of SACS mRNA20458559
C547126AZM551248AZM551248 results in increased expression of SACS mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SACS mRNA20106945|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SACS mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SACS mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SACS mRNA"20382639
D004958EstradiolEstradiol results in increased expression of SACS mRNA20106945|2301914
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SACS mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SACS mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SACS mRNA27571134
D019256Cadmium Chloride[lead chloride co-treated with Cadmium Chloride] results in increased expression of SACS mRNA25016106
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SACS gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SACS mRNA19320972
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SACS mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SACS mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of SACS mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SACS mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SACS mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SACS mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SACS mRNA27392435|2759478
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SACS mRNA22129741
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SACS mRNA28196854
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SACS gene20938992
C010974glyphosateglyphosate results in increased expression of SACS mRNA25636363
D017313FenretinideFenretinide results in increased expression of SACS mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SACS mRNA21179406
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SACS mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SACS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SACS mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SACS mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SACS mRNA27392435
C410337K 7174K 7174 results in increased expression of SACS mRNA24086573
D007854LeadLead affects the expression of SACS mRNA28903495
C029891lead chloride[lead chloride co-treated with Cadmium Chloride] results in increased expression of SACS mRNA25016106
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SACS mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SACS gene20938992
C523799MRK 003MRK 003 results in increased expression of SACS mRNA21169257
C568376MT19c compoundMT19c compound results in increased expression of SACS mRNA21781307
C029938nickel sulfatenickel sulfate results in decreased expression of SACS mRNA22714537
D010269ParaquatParaquat results in increased expression of SACS mRNA22563483
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SACS mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of SACS mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of SACS mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of SACS mRNA19429403
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SACS mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SACS mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SACS mRNA20813756|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of SACS mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of SACS mRNA23557933
D011794QuercetinQuercetin results in increased expression of SACS mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SACS mRNA19167446
D012643SeleniumSelenium results in decreased expression of SACS mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of SACS mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of SACS gene28589171
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SACS mRNA21641980
C061133tamibarotenetamibarotene results in decreased expression of SACS mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SACS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SACS mRNA19770486
D013853ThioacetamideThioacetamide results in increased expression of SACS mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SACS mRNA28065790
D014212TretinoinTretinoin results in decreased expression of SACS mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of SACS mRNA25979313
C029297vinylidene chloridevinylidene chloride results in increased expression of SACS mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of SACS mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030544Hsp70 protein binding-IPI19208651  
GO:0051087chaperone binding-IDA19208651  
GO:0070628proteasome binding-IPI19208651  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-NAS10655055  
GO:0090084negative regulation of inclusion body assembly-IMP19208651  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19208651  
GO:0005737cytoplasm-IDA19208651  
GO:0005739mitochondrion-IDA19208651  
GO:0030424axon-TAS19208651  
GO:0030425dendrite-TAS19208651  
GO:0070852cell body fiber-TAS19208651  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24504365RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. (2014 Mar 18)Tsuta KBr J Cancer