Gene: FGF20

26281
FGF-20|RHDA2
fibroblast growth factor 20
protein-coding
8p22
Ensembl:ENSG00000078579 MIM:605558 Vega:OTTHUMG00000096964 UniprotKB:Q9NP95
NG_015978.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.295e-1 (AD)  3.378e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAF3IP30.699
ST8SIA40.69
P2RY130.69
GAPT0.67
HLA-DOA0.667
ATP8B40.664
CX3CR10.664
MPEG10.66
SUSD30.659
LPCAT20.655

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.364
GRIN2C-0.335
HHATL-0.334
SLC25A48-0.327
CDH20-0.326
SALL3-0.322
LRP4-0.32
CNTFR-0.305
TTYH1-0.303
BGLAP-0.301

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF20 protein results in increased phosphorylation of MAPK1 protein]12704805
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF20 protein results in increased phosphorylation of MAPK3 protein]12704805
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of FGF20 protein12704805
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FGF20 mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGF20 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF20 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of FGF20 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of FGF20 mRNA26079696
D004390ChlorpyrifosChlorpyrifos results in decreased expression of FGF20 mRNA17589599|1850231
D003471CuprizoneCuprizone results in decreased expression of FGF20 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FGF20 mRNA23640034
D003976DiazinonDiazinon results in decreased expression of FGF20 mRNA17589599
C025340manganese chloridemanganese chloride results in increased expression of FGF20 mRNA28986288
D008727MethotrexateMethotrexate affects the expression of FGF20 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FGF20 mRNA"20188158
D015232DinoprostoneFGF20 protein results in increased abundance of Dinoprostone12360478
C005556propionaldehydepropionaldehyde results in increased expression of FGF20 mRNA26079696
C105686SU 5402SU 5402 results in decreased activity of FGF20 protein12704805
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FGF20 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-TAS11306498  
GO:0005104fibroblast growth factor receptor binding-IEA-  
GO:0008083growth factor activity-ISS-  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0043395heparan sulfate proteoglycan binding-TAS11306498  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:0090722receptor-receptor interaction-IDA24157794  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007165signal transduction-TAS10913340  
GO:0007267cell-cell signaling-TAS10913340  
GO:0008284positive regulation of cell proliferation-TAS11306498  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS11306498  16988046  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014059regulation of dopamine secretion-TAS16988046  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IDA16988046  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060043regulation of cardiac muscle cell proliferation-IEA-  
GO:0060113inner ear receptor cell differentiation-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:1904340positive regulation of dopaminergic neuron differentiation-TAS18982104  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839122Signaling by activated point mutants of FGFR1TAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-1839126FGFR2 mutant receptor activationTAS
R-HSA-1839130Signaling by activated point mutants of FGFR3TAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190239FGFR3 ligand binding and activationTAS
R-HSA-190241FGFR2 ligand binding and activationTAS
R-HSA-190242FGFR1 ligand binding and activationTAS
R-HSA-190322FGFR4 ligand binding and activationTAS
R-HSA-190371FGFR3b ligand binding and activationTAS
R-HSA-190372FGFR3c ligand binding and activationTAS
R-HSA-190373FGFR1c ligand binding and activationTAS
R-HSA-190375FGFR2c ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2033514FGFR3 mutant receptor activationTAS
R-HSA-2033519Activated point mutants of FGFR2TAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-5654219Phospholipase C-mediated cascade: FGFR1TAS
R-HSA-5654221Phospholipase C-mediated cascade; FGFR2TAS
R-HSA-5654227Phospholipase C-mediated cascade; FGFR3TAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654688SHC-mediated cascade:FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654693FRS-mediated FGFR1 signalingTAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654699SHC-mediated cascade:FGFR2TAS
R-HSA-5654700FRS-mediated FGFR2 signalingTAS
R-HSA-5654704SHC-mediated cascade:FGFR3TAS
R-HSA-5654706FRS-mediated FGFR3 signalingTAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654710PI-3K cascade:FGFR3TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654726Negative regulation of FGFR1 signalingTAS
R-HSA-5654727Negative regulation of FGFR2 signalingTAS
R-HSA-5654732Negative regulation of FGFR3 signalingTAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26174813New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. (2015 Sep)Alemany SAm J Med Genet B Neuropsychiatr Genet