Gene: AK5

26289
AK6
adenylate kinase 5
protein-coding
1p31.1
Ensembl:ENSG00000154027 MIM:608009 Vega:OTTHUMG00000009796 UniprotKB:Q9Y6K8
NC_000001.11
SNP Mapped
2   ANCO-SNPs
ND
0   
4.603e-1 (AD)  4.650e-3 (ND)   (Frontal_Cortex)
9.678e-1 (AD)  6.575e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12131772chr1:77417986 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs10873937chr1:77414142 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17486075chr1:77788391AK5Gene body2.671e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNCA0.963
PPM1H0.961
HSPA12A0.955
FAM131B0.954
NDRG30.953
TSPAN50.952
MAPK90.952
REPS20.952
NAPB0.951
WASF10.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.513
OR4F5-0.491
OR4F29-0.488
RUNX3-0.466
CSAG1-0.465
MTRNR2L10-0.456
CXCR2-0.454
KCNJ15-0.454
TFPI2-0.451
GJB2-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of AK5 mRNA"23829299
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of AK5 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AK5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AK5 mRNA"27188386
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of AK5 mRNA]18700144
C016601afimoxifeneAK5 results in decreased susceptibility to afimoxifene21233418
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AK5 mRNA24449571
D001374AzacitidineAzacitidine results in increased expression of AK5 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AK5 mRNA20064835
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA20823114
C452139BIRB 796BIRB 796 results in increased expression of AK5 mRNA24303162
C006780bisphenol Abisphenol A results in increased expression of AK5 mRNA26364221
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of AK5 mRNA20971185
D019327Copper SulfateCopper Sulfate affects the expression of AK5 mRNA19549813
D000069439DasatinibDasatinib results in decreased expression of AK5 mRNA20579391
D013759DronabinolDronabinol results in decreased expression of AK5 mRNA21955143
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA20823114
D002117CalcitriolCalcitriol results in decreased expression of AK5 mRNA26485663
D000431EthanolEthanol results in decreased expression of AK5 mRNA21955143
D004397FonofosFonofos results in increased methylation of AK5 promoter22847954
D019833GenisteinGenistein results in decreased expression of AK5 mRNA22228119
C544151jinfukangjinfukang results in increased expression of AK5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AK5 mRNA23086925|2479639
D007854LeadLead affects the expression of AK5 mRNA28903495
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of AK5 mRNA20823114
D008694MethamphetamineAK5 gene SNP affects the susceptibility to Methamphetamine18316681
C004925methylmercuric chloridemethylmercuric chloride affects the expression of AK5 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AK5 mRNA28001369
D009020MorphineMorphine results in decreased expression of AK5 mRNA21955143
D009538NicotineNicotine results in increased expression of AK5 mRNA21955143
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of AK5 mRNA20971185
D010278ParathionParathion results in increased methylation of AK5 promoter22847954
C410127PCB 180PCB 180 results in decreased expression of AK5 mRNA23829299
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of AK5 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AK5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of AK5 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of AK5 mRNA20813756
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of AK5 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of AK5 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AK5 mRNA25895662
C012568terbufosterbufos results in increased methylation of AK5 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AK5 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AK5 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of AK5 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of AK5 mRNA24935251
D014415TunicamycinTunicamycin results in increased expression of AK5 mRNA17127020
D014635Valproic AcidValproic Acid results in decreased expression of AK5 mRNA23179753
C088658zoledronic acidzoledronic acid results in decreased expression of AK5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004017adenylate kinase activity-IEA-  
GO:0004550nucleoside diphosphate kinase activity-IDA23416111  
GO:0005524ATP binding-IEA-  
GO:0019206nucleoside kinase activity-EXP10215863  
GO ID GO Term Qualifier Evidence PubMed
GO:0006165nucleoside diphosphate phosphorylation-IDA23416111  
GO:0006172ADP biosynthetic process-TAS10215863  
GO:0006173dADP biosynthetic process-TAS10215863  
GO:0009142nucleoside triphosphate biosynthetic process-IDA23416111  
GO:0009220pyrimidine ribonucleotide biosynthetic process-TAS10215863  
GO:0015949nucleobase-containing small molecule interconversion-TAS-  
GO:0046034ATP metabolic process-IEA-  
GO:0046940nucleoside monophosphate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal