Gene info: ID 26291

Gene: FGF21

GENE ID: 26291

Synonyms: -

Description: fibroblast growth factor 21

Gene type: protein-coding

Location: 19q13.33

dbXrefs: Ensembl:ENSG00000105550 MIM:609436 Vega:OTTHUMG00000183326 UniprotKB:Q9NSA1

RefSeq: NG_033945.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.323e-1 (AD) 4.241e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HTR3D	0.696
MUC17	0.635
TMPRSS13	0.61
CRYBA4	0.606
GJA8	0.602
PLA2G4E	0.599
FAM83C	0.599
IL20	0.59
SLC2A9	0.58
HUS1B	0.579

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OMG	-0.266
KRT13	-0.249
SPRR3	-0.248
ACY3	-0.238
PIGP	-0.233
HYAL3	-0.221
MDH1B	-0.217
GPR17	-0.215
HAPLN1	-0.212
SPRR1A	-0.21

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FGF21 mRNA"	28903501
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FGF21 mRNA"	21354444
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of FGF21 mRNA	28329830
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF21 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FGF21 mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FGF21 mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF21 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF21 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF21 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF21 mRNA"	25510870
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FGF21 mRNA"	28163111
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of FGF21 mRNA"	28163111
D000082	Acetaminophen	Acetaminophen results in decreased expression of FGF21 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of FGF21 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of FGF21 mRNA	17562736
D000082	Acetaminophen	Acetaminophen promotes the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D000082	Acetaminophen	Acetaminophen results in increased expression of FGF21 mRNA	28088388
D000082	Acetaminophen	Dexamethasone promotes the reaction [Acetaminophen results in increased expression of FGF21 mRNA]	28088388
D000082	Acetaminophen	FGF21 protein affects the reaction [Dexamethasone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]	28088388
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA]	22917661
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased secretion of FGF21 protein]	22917661
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA]	22129741
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA	22129741
D020106	Acrylamide	Acrylamide results in decreased expression of FGF21 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FGF21 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of FGF21 gene	28458013
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FGF21 mRNA	19770486
D000638	Amiodarone	Amiodarone results in increased expression of FGF21 mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGF21 mRNA	16483693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FGF21 mRNA	18164116
D001629	Bezafibrate	Bezafibrate results in increased expression of FGF21 mRNA	22338096
D001629	Bezafibrate	Bezafibrate results in increased expression of FGF21 protein	22338096
D001629	Bezafibrate	Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]	22338096
D001629	Bezafibrate	Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]	22338096
D001629	Bezafibrate	[Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein	22338096
D001629	Bezafibrate	[Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein	22338096
D001629	Bezafibrate	Bezafibrate results in increased expression of FGF21 mRNA	18787029\|2085479
D001629	Bezafibrate	Bezafibrate results in increased expression of FGF21 protein	22338096
D001629	Bezafibrate	Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]	22338096
D001629	Bezafibrate	Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]	22338096
D001629	Bezafibrate	PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]	20854792
C006780	bisphenol A	bisphenol A affects the expression of FGF21 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of FGF21 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of FGF21 mRNA	25181051
D001786	Blood Glucose	FGF21 gene mutant form results in decreased abundance of Blood Glucose	28123933
D001786	Blood Glucose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose	28123933
D001786	Blood Glucose	FGF21 protein affects the abundance of Blood Glucose	15902306
D000069286	Bortezomib	[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of FGF21 mRNA	25522274
D002079	Butter	[Butter co-treated with Dietary Fats] results in increased expression of FGF21 mRNA	24450870
D002087	Butyrates	Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]	22338096
D002087	Butyrates	[Butyrates results in decreased activity of HDAC3 protein] which results in increased expression of FGF21 mRNA	22338096
D002087	Butyrates	Butyrates results in increased expression of FGF21 mRNA	22338096
D002087	Butyrates	Butyrates results in increased expression of FGF21 protein	22338096
D002087	Butyrates	Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]	22338096
D002087	Butyrates	Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]	22338096
D002087	Butyrates	Butyrates results in increased expression of FGF21 protein	22338096
D002087	Butyrates	FGF21 protein affects the reaction [Butyrates results in increased abundance of Ketone Bodies]	22338096
D002087	Butyrates	FGF21 protein affects the reaction [Butyrates results in increased expression of CPT1A mRNA]	22338096
D002087	Butyrates	FGF21 protein affects the reaction [Butyrates results in increased expression of HMGCS2 mRNA]	22338096
D002087	Butyrates	FGF21 protein affects the reaction [Butyrates results in increased oxidation of Fatty Acids]	22338096
D002087	Butyrates	FGF21 protein affects the susceptibility to Butyrates	22338096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of FGF21 mRNA	16929488\|2733941
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of FGF21 mRNA	25270620
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA	20350562\|2517884
D002794	Choline	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 protein	25178843
D002794	Choline	"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of FGF21 mRNA"	28163111
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF21 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FGF21 mRNA	28163111
D002794	Choline	Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]	25178843
D002794	Choline	Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 protein]	25178843
D002794	Choline	NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]	20350562
D002922	Ciguatoxins	Ciguatoxins affects the expression of FGF21 mRNA	18353800
C014416	citreoviridin	citreoviridin results in decreased expression of FGF21 mRNA	28645467
C014416	citreoviridin	citreoviridin results in decreased expression of FGF21 mRNA	28645467
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in increased expression of FGF21 mRNA]	23839791
C007095	cobaltiprotoporphyrin	tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in increased expression of FGF21 mRNA]]	23839791
C018021	cobaltous chloride	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA]	22917661
C018021	cobaltous chloride	Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased secretion of FGF21 protein]	22917661
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of and results in decreased stability of FGF21 mRNA	22917661
C018021	cobaltous chloride	cobaltous chloride results in decreased secretion of FGF21 protein	22917661
D003314	Corn Oil	Corn Oil affects the expression of FGF21 mRNA	16360708
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of FGF21 mRNA	25497113
D016572	Cyclosporine	Cyclosporine results in increased expression of FGF21 mRNA	20106945\|2798913
D003907	Dexamethasone	Dexamethasone promotes the reaction [NR1I2 protein binds to FGF21 promoter]	28088388
D003907	Dexamethasone	Dexamethasone results in increased expression of FGF21 mRNA	28088388
D003907	Dexamethasone	Dexamethasone results in increased expression of FGF21 protein	28088388
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D003907	Dexamethasone	NR1I2 protein affects the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D003907	Dexamethasone	Acetaminophen promotes the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D003907	Dexamethasone	Dexamethasone promotes the reaction [Acetaminophen results in increased expression of FGF21 mRNA]	28088388
D003907	Dexamethasone	Dexamethasone promotes the reaction [NR1I2 protein binds to FGF21 promoter]	28088388
D003907	Dexamethasone	Dexamethasone results in decreased expression of FGF21 mRNA	22733784
D003907	Dexamethasone	Dexamethasone results in increased expression of FGF21 mRNA	28088388
D003907	Dexamethasone	Dexamethasone results in increased expression of FGF21 protein	28088388
D003907	Dexamethasone	FGF21 protein affects the reaction [Dexamethasone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]	28088388
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D003907	Dexamethasone	NR1I2 protein affects the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D003976	Diazinon	Diazinon affects the expression of FGF21 mRNA	19130878
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of FGF21 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of FGF21 mRNA	28962523
D002945	Cisplatin	Cisplatin results in decreased expression of FGF21 mRNA	22023808
D004026	Dieldrin	Dieldrin results in decreased expression of FGF21 mRNA	19130878
D004041	Dietary Fats	"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of FGF21 mRNA"	24872412
D004041	Dietary Fats	Dietary Fats results in decreased expression of FGF21 mRNA	25016146
D004041	Dietary Fats	[Butter co-treated with Dietary Fats] results in increased expression of FGF21 mRNA	24450870
D004041	Dietary Fats	[Margarine co-treated with Dietary Fats] results in increased expression of FGF21 mRNA	24450870
D004041	Dietary Fats	[Olive Oil co-treated with Dietary Fats] results in increased expression of FGF21 mRNA	24450870
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA]	24769090
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 protein]	24769090
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of FGF21 mRNA	20123618
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FGF21 mRNA	24535843
D004052	Diethylnitrosamine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA]	22129741
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FGF21 mRNA	18164116
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA	22129741
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA	22129741
D004229	Dithiothreitol	Dithiothreitol results in increased expression of FGF21 mRNA	27226639
D004229	Dithiothreitol	"indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]"	27226639
D004229	Dithiothreitol	Dithiothreitol results in increased expression of FGF21 mRNA	27226639
D004229	Dithiothreitol	"indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]"	27226639
D019297	2,4-Dinitrophenol	"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of FGF21 mRNA"	24872412
D000431	Ethanol	Ethanol inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of FGF21 protein]	28131861
D000431	Ethanol	Ethanol results in increased expression of FGF21 protein	28131861
D000431	Ethanol	FGF21 gene mutant form results in increased susceptibility to Ethanol	28131861
D000431	Ethanol	PPARA protein affects the reaction [Ethanol results in increased expression of FGF21 protein]	28131861
D000431	Ethanol	[[PPARA protein co-treated with CYP2A5 protein] affects the susceptibility to Ethanol] which affects the expression of FGF21 protein	28131861
D015738	Famotidine	Famotidine results in increased expression of FGF21 protein	8774986
D005227	Fatty Acids	FGF21 protein affects the reaction [Butyrates results in increased oxidation of Fatty Acids]	22338096
D005227	Fatty Acids	FGF21 protein results in increased oxidation of Fatty Acids	22338096
D011345	Fenofibrate	Fenofibrate results in increased expression of FGF21 mRNA	22338096
D011345	Fenofibrate	Fenofibrate results in increased expression of FGF21 protein	22338096
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of FGF21 mRNA	28329830
D005485	Flutamide	Flutamide results in increased expression of FGF21 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF21 mRNA	20938992
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACA mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ACACB mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of ALDOB mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of KHK mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MLXIPL mRNA alternative form]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of PKLR mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of SCD1 mRNA]	28123933
D005632	Fructose	FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]	28123933
D005632	Fructose	FGF21 gene mutant form results in increased susceptibility to Fructose	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased abundance of Blood Glucose	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of APOB mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in decreased expression of DGAT2 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL2 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CCL3 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of CD68 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of DGAT1 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of MMP2 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB1 mRNA	28123933
D005632	Fructose	[FGF21 gene mutant form results in increased susceptibility to Fructose] which results in increased expression of TGFB2 mRNA	28123933
D005632	Fructose	Fructose results in increased expression of FGF21 mRNA	28123933
D005632	Fructose	Fructose results in increased secretion of FGF21 protein	28123933
D005632	Fructose	MLXIPL gene mutant form inhibits the reaction [Fructose results in increased expression of FGF21 mRNA]	28123933
D005632	Fructose	MLXIPL gene mutant form inhibits the reaction [Fructose results in increased secretion of FGF21 protein]	28123933
C039281	furan	furan results in increased expression of FGF21 mRNA	24183702
C039281	furan	furan results in increased expression of FGF21 mRNA	26194646
D005947	Glucose	FGF21 protein affects the uptake of Glucose	15902306
D005947	Glucose	Glucose results in increased expression of FGF21 mRNA	27226639
D005947	Glucose	"indolo(3,2-b)carbazole inhibits the reaction [Glucose results in increased expression of FGF21 mRNA]"	27226639
D005947	Glucose	Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased expression of FGF21 mRNA]	27226639
D005947	Glucose	FGF21 protein affects the uptake of Glucose	15902306
D005947	Glucose	Glucose deficiency results in increased expression of FGF21 mRNA	27226639
D005947	Glucose	Glucose results in increased secretion of FGF21 protein	28123933
D005947	Glucose	"indolo(3,2-b)carbazole inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]"	27226639
D005947	Glucose	Tetrachlorodibenzodioxin inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]	27226639
C412815	GW 4064	GW 4064 results in increased expression of FGF21 mRNA	26655953
C453899	GW 7647	GW 7647 results in increased expression of FGF21 mRNA	27226639
C453899	GW 7647	"indolo(3,2-b)carbazole inhibits the reaction [GW 7647 results in increased expression of FGF21 mRNA]"	27226639
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of FGF21 mRNA	25270620
C016517	indole-3-carbinol	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA]	22129741
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA	22129741
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA	22129741
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [Glucose results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [GW 7647 results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [CREB3L3 protein results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [PPARA protein results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]"	27226639
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole promotes the reaction [[AHR protein binds to ARNT protein] which binds to FGF21 promoter]"	27226639
C541917	INT 131	INT 131 results in increased expression of FGF21 mRNA	19452630
D007657	Ketone Bodies	FGF21 protein affects the reaction [Butyrates results in increased abundance of Ketone Bodies]	22338096
D007657	Ketone Bodies	FGF21 protein results in increased chemical synthesis of Ketone Bodies	22338096
D064747	Lansoprazole	Lansoprazole results in increased expression of FGF21 protein	8774986
C008261	lead acetate	lead acetate results in increased expression of FGF21 mRNA	22609695
D008383	Margarine	[Margarine co-treated with Dietary Fats] results in increased expression of FGF21 mRNA	24450870
D008701	Methapyrilene	Methapyrilene results in increased expression of FGF21 mRNA	22484513
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA	20350562\|2517884
D008715	Methionine	[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 protein	25178843
D008715	Methionine	"[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of FGF21 mRNA"	28163111
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF21 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FGF21 mRNA	28163111
D008715	Methionine	Methionine deficiency results in increased expression of FGF21 mRNA	25178843
D008715	Methionine	Methionine deficiency results in increased expression of FGF21 protein	25178843
D008715	Methionine	Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]	25178843
D008715	Methionine	Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 protein]	25178843
D008715	Methionine	NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]	20350562
C002950	methylformamide	methylformamide analog results in increased expression of FGF21 mRNA	17040096
C002950	methylformamide	methylformamide results in increased expression of FGF21 mRNA	17040096
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of FGF21 mRNA]	28088388
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA	20123618
C016599	mono-(2-ethylhexyl)phthalate	PPARA gene mutant form inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA]	20123618
C016599	mono-(2-ethylhexyl)phthalate	PPARA inhibits the reaction [PPARA gene mutant form inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA]]	20123618
C500085	muraglitazar	muraglitazar results in increased expression of FGF21 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of FGF21 mRNA	15674844
C560625	N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine	N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]]	27226639
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FGF21 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FGF21 mRNA"	25620056
C051752	nefazodone	nefazodone results in increased expression of FGF21 mRNA	24136188
D009532	Nickel	Nickel affects the expression of FGF21 mRNA	19130878
D000069463	Olive Oil	[Olive Oil co-treated with Dietary Fats] results in increased expression of FGF21 mRNA	24450870
D010100	Oxygen	Oxygen deficiency results in decreased expression of FGF21 mRNA	22917661
D010100	Oxygen	Oxygen deficiency results in decreased secretion of FGF21 protein	22917661
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF21 mRNA"	25510870
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FGF21 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital affects the expression of FGF21 mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FGF21 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of FGF21 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of FGF21 mRNA	19482888\|2309116
C060836	pioglitazone	pioglitazone results in increased expression of FGF21 mRNA	21720023
C060836	pioglitazone	pioglitazone results in increased expression of FGF21 mRNA	21720023
C006253	pirinixic acid	[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of FGF21 mRNA	20032461
C006253	pirinixic acid	pirinixic acid results in increased expression of FGF21 mRNA	18301758\|1844570
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of FGF21 mRNA	22698814\|2890350
D011441	Propylthiouracil	Propylthiouracil results in increased expression of FGF21 mRNA	24780913
C059514	resveratrol	resveratrol results in increased expression of FGF21 mRNA	24184811
C059514	resveratrol	resveratrol results in increased expression of FGF21 protein	24184811
C089730	rosiglitazone	rosiglitazone results in increased expression of FGF21 mRNA	21720023
C089730	rosiglitazone	rosiglitazone results in increased expression of FGF21 mRNA	19452630\|2172002
C089730	rosiglitazone	rosiglitazone results in increased expression of FGF21 mRNA	21515302
D015842	Serine Proteinase Inhibitors	Serine Proteinase Inhibitors inhibits the reaction [FAP protein results in increased cleavage of FGF21 protein]	26797127
D015842	Serine Proteinase Inhibitors	Serine Proteinase Inhibitors results in decreased cleavage of FGF21 protein	26797127
C017947	sodium arsenite	sodium arsenite results in decreased expression of FGF21 mRNA	25270620
C017947	sodium arsenite	sodium arsenite results in increased expression of FGF21 mRNA	16014739
C016104	sodium bichromate	sodium bichromate results in increased expression of FGF21 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in increased expression of FGF21 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of FGF21 mRNA	25993096
C525422	SRT1720	SRT1720 results in increased expression of FGF21 mRNA	24184811
C525422	SRT1720	SRT1720 results in increased expression of FGF21 protein	24184811
D013311	Streptozocin	FGF21 protein affects the reaction [Streptozocin results in increased expression of AIFM1]	23499715
D013311	Streptozocin	FGF21 protein affects the reaction [Streptozocin results in increased expression of CASP12 protein modified form]	23499715
D013311	Streptozocin	FGF21 protein affects the reaction [Streptozocin results in increased expression of DDIT3]	23499715
D013311	Streptozocin	FGF21 protein affects the susceptibility to Streptozocin	23499715
D016559	Tacrolimus	Tacrolimus results in decreased expression of FGF21 mRNA	25270620
D013629	Tamoxifen	Tamoxifen affects the expression of FGF21 mRNA	20937368
C501413	tesaglitazar	tesaglitazar results in increased expression of FGF21 mRNA	21515302
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of FGF21 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Glucose results in increased expression of FGF21 mRNA]	27226639
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA	24769090
D013749	Tetrachlorodibenzodioxin	AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA]	24769090
D013749	Tetrachlorodibenzodioxin	AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 protein]	24769090
D013749	Tetrachlorodibenzodioxin	Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA]	24769090
D013749	Tetrachlorodibenzodioxin	Diethylhexyl Phthalate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FGF21 protein]	24769090
D013749	Tetrachlorodibenzodioxin	FGF21 protein results in decreased susceptibility to Tetrachlorodibenzodioxin	24769090
D013749	Tetrachlorodibenzodioxin	N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]]	27226639
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGF21 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FGF21 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Glucose deficiency results in increased expression of FGF21 mRNA]	27226639
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]	27226639
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to FGF21 promoter]	27226639
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FGF21 promoter]	24769090
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of FGF21 mRNA]	21846477
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF21 mRNA	19770486\|2722663
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGF21 mRNA	21846477\|2476909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGF21 protein	24769090
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FGF21 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FGF21 mRNA	21724226
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of FGF21 mRNA	28973375
D019284	Thapsigargin	"indolo(3,2-b)carbazole inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]"	27226639
D019284	Thapsigargin	N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]]	27226639
D019284	Thapsigargin	Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]	27226639
D019284	Thapsigargin	Thapsigargin results in increased expression of FGF21 mRNA	27226639
C055421	tin mesoporphyrin	tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in increased expression of FGF21 mRNA]]	23839791
D014241	Trichloroethylene	Trichloroethylene results in increased expression of FGF21 mRNA	25549359\|2897337
C012589	trichostatin A	trichostatin A results in increased expression of FGF21 mRNA	22338096
C012589	trichostatin A	trichostatin A results in increased expression of FGF21 protein	22338096
C012589	trichostatin A	trichostatin A results in increased expression of FGF21 protein	22338096
D014280	Triglycerides	FGF21 protein affects the abundance of Triglycerides	15902306
C046488	trimethyltin	trimethyltin results in increased expression of FGF21 mRNA	24002884
C057693	troglitazone	troglitazone results in decreased expression of FGF21 mRNA	28973697
C057693	troglitazone	troglitazone results in increased expression of FGF21 mRNA	21515302
D014635	Valproic Acid	Valproic Acid results in increased expression of FGF21 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of FGF21 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of FGF21 mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in decreased expression of FGF21 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of FGF21 mRNA	24489787
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of FGF21 gene	25560391
C030106	very low density lipoprotein triglyceride	FGF21 gene mutant form inhibits the reaction [Fructose results in increased secretion of very low density lipoprotein triglyceride]	28123933
C030106	very low density lipoprotein triglyceride	FGF21 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride	28123933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005104	fibroblast growth factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	18829467 19059246 19117008
GO:0008083	growth factor activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	10858549
GO:0007267	cell-cell signaling	-	TAS	10858549
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010898	positive regulation of triglyceride catabolic process	-	IEA	-
GO:0010988	regulation of low-density lipoprotein particle clearance	-	NAS	22378787
GO:0014823	response to activity	-	IEA	-
GO:0030968	endoplasmic reticulum unfolded protein response	-	IEA	-
GO:0031667	response to nutrient levels	-	IEA	-
GO:0035690	cellular response to drug	-	IEA	-
GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process	-	NAS	22378787
GO:0046326	positive regulation of glucose import	-	IDA	17623664
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IDA	17623664
GO:0071333	cellular response to glucose stimulus	-	IEA	-
GO:0071377	cellular response to glucagon stimulus	-	IEA	-
GO:0071404	cellular response to low-density lipoprotein particle stimulus	-	IEA	-
GO:0072577	endothelial cell apoptotic process	-	IEA	-
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	-	IEA	-
GO:1901215	negative regulation of neuron death	-	IEA	-
GO:1904640	response to methionine	-	IEA	-
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	10858549
GO:0005615	extracellular space	-	IEA	-
GO:0005623	cell	-	IEA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05218	Melanoma

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	IEA
R-HSA-189200	Cellular hexose transport	TAS
R-HSA-382551	Transport of small molecules	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	IEA
R-HSA-8963899	Plasma lipoprotein remodeling	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27917437	Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. (2017 Apr)	Sinha-Hikim I	Cell Tissue Res
28467924	FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. (2017 May 2)	Soberg S	Cell Metab
23887638	Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. (2013 Oct)	Chow WS	Arterioscler Thromb Vasc Biol
27611701	Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes. (2017 Jan)	Woo YC	Clin Endocrinol (Oxf)