Gene: GBE1

2632
APBD|GBE|GSD4
1,4-alpha-glucan branching enzyme 1
protein-coding
3p12.2
Ensembl:ENSG00000114480 MIM:607839 Vega:OTTHUMG00000158978 UniprotKB:Q04446
NG_011810.1
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.408e-1 (AD)  2.137e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2J10.826
CAST0.814
VMP10.813
DDX180.811
TMF10.802
ELL20.799
COPB10.798
PICALM0.798
ABCE10.794
RB10.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.447
OR4F29-0.437
HES5-0.319
NXNL1-0.265
BTBD17-0.256
ARSF-0.251
PYGM-0.237
C16orf74-0.236
SLC13A5-0.23
ADAMTSL5-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GBE1 mRNA"21346803
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of GBE1 protein"22649188
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GBE1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GBE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GBE1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GBE1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GBE1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GBE1 mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of GBE1 mRNA19483382
C547126AZM551248AZM551248 results in decreased expression of GBE1 mRNA22323515
C487081belinostatbelinostat results in decreased expression of GBE1 mRNA27188386
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of GBE1 mRNA26377693
D001553BenzbromaroneBenzbromarone affects the expression of GBE1 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GBE1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GBE1 mRNA23735875
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of GBE1 mRNA20823114
D004958EstradiolEstradiol results in decreased expression of GBE1 mRNA21632981
D004958EstradiolEstradiol results in decreased expression of GBE1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of GBE1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GBE1 gene28505145
D002065BuspironeBuspirone results in decreased expression of GBE1 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of GBE1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GBE1 mRNA25596134
C037123cadmium sulfatecadmium sulfate results in increased expression of GBE1 mRNA12064557|1467641
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GBE1 mRNA17484886
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of GBE1 mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GBE1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of GBE1 mRNA23125180
D002794CholineCholine affects the expression of GBE1 mRNA17616785
C059262cidofovircidofovir results in increased expression of GBE1 mRNA25596134
D002994ClofibrateClofibrate affects the expression of GBE1 mRNA19483382
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of GBE1 mRNA18078969
C018021cobaltous chloridecobaltous chloride results in increased expression of GBE1 mRNA15094311|1937684
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GBE1 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of GBE1 mRNA15094311
C018021cobaltous chloridecobaltous chloride results in increased expression of GBE1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of GBE1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of GBE1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GBE1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of GBE1 mRNA20106945|2559613
D016572CyclosporineCyclosporine results in decreased expression of GBE1 mRNA19770486
D016572CyclosporineCyclosporine results in increased expression of GBE1 mRNA25596134
D003676DeferoxamineDeferoxamine results in increased expression of GBE1 mRNA15094311
D003676DeferoxamineDeferoxamine results in increased expression of GBE1 mRNA15094311
D003907DexamethasoneDexamethasone results in increased expression of GBE1 mRNA25047013
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of GBE1 mRNA20823114
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of GBE1 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of GBE1 mRNA27594783
D002945CisplatinCisplatin results in increased expression of GBE1 mRNA25596134|2739243
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of GBE1 mRNA23625948
C000944dicrotophosdicrotophos results in decreased expression of GBE1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of GBE1 mRNA18042831
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of GBE1 mRNA27638505
C118739entinostatentinostat results in decreased expression of GBE1 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GBE1 mRNA22079256
D005001EthionineEthionine affects the expression of GBE1 mRNA19483382
D011345FenofibrateFenofibrate results in increased expression of GBE1 mRNA25596134
D011345FenofibrateFenofibrate results in decreased expression of GBE1 mRNA25596134
D005485FlutamideFlutamide results in increased expression of GBE1 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of GBE1 mRNA24136188
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of GBE1 mRNA16849584
D007052IbuprofenIbuprofen results in increased expression of GBE1 mRNA25596134
C410337K 7174K 7174 results in increased expression of GBE1 mRNA24086573
C025340manganese chloridemanganese chloride results in decreased expression of GBE1 mRNA27913844
C025340manganese chloridemanganese chloride results in increased methylation of GBE1 gene27913844
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of GBE1 mRNA20823114
D008687MetforminMetformin results in increased expression of GBE1 mRNA25596134
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GBE1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GBE1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GBE1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GBE1 mRNA"25620056
D009532NickelNickel results in increased expression of GBE1 mRNA24084258
C022838nickel chloridenickel chloride results in increased expression of GBE1 mRNA15094311
C022838nickel chlorideHIF1A protein affects the reaction [nickel chloride results in increased expression of GBE1 mRNA]15094311
C022838nickel chloridenickel chloride results in increased expression of GBE1 mRNA15094311
C022838nickel chloridenickel chloride affects the expression of GBE1 mRNA22110744
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of GBE1 mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of GBE1 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GBE1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of GBE1 mRNA15094311|2423605
D010100OxygenOxygen deficiency results in increased expression of GBE1 mRNA20880076
D000073878Palm OilPalm Oil results in decreased expression of GBE1 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of GBE1 mRNA23892564
C046012pentanalpentanal results in decreased expression of GBE1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of GBE1 mRNA23602845
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of GBE1 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of GBE1 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GBE1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of GBE1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GBE1 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GBE1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GBE1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of GBE1 mRNA17426115
C006253pirinixic acidpirinixic acid affects the expression of GBE1 mRNA19483382
D010936Plant ExtractsPlant Extracts results in increased expression of GBE1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GBE1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GBE1 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of GBE1 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of GBE1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of GBE1 mRNA24780913
C031280pyrazolepyrazole results in increased expression of GBE1 mRNA17945193
D011794QuercetinQuercetin results in increased expression of GBE1 mRNA19729006
D015474IsotretinoinIsotretinoin results in decreased expression of GBE1 mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of GBE1 mRNA25596134
D012834SilverSilver results in increased expression of GBE1 mRNA27131904
C016104sodium bichromatesodium bichromate affects the expression of GBE1 mRNA22110744
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GBE1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GBE1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GBE1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GBE1 mRNA16267337
D013849ThimerosalThimerosal results in decreased expression of GBE1 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of GBE1 mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of GBE1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of GBE1 mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GBE1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of GBE1 mRNA19448997
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of GBE1 mRNA18078969
D014635Valproic AcidValproic Acid affects the expression of GBE1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GBE1 mRNA23179753|2718838
C111237vorinostatvorinostat results in decreased expression of GBE1 mRNA27188386
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GBE1 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038441,4-alpha-glucan branching enzyme activity-EXP8613547  
GO:00038441,4-alpha-glucan branching enzyme activity-IBA21873635  
GO:00038441,4-alpha-glucan branching enzyme activity-IDA26199317  
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds-IEA-  
GO:0005515protein binding-IPI24837458  
GO:0030246carbohydrate binding-IEA-  
GO:0043169cation binding-IEA-  
GO:01027521,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IBA21873635  
GO:0005977glycogen metabolic process-TAS8613547  
GO:0005978glycogen biosynthetic process-IBA21873635  
GO:0005978glycogen biosynthetic process-IDA26199317  
GO:0005978glycogen biosynthetic process-IEA-  
GO:0005978glycogen biosynthetic process-TAS-  
GO:0006091generation of precursor metabolites and energy-TAS8613547  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00500Starch and sucrose metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-3229121Glycogen storage diseasesTAS
R-HSA-3322077Glycogen synthesisTAS
R-HSA-3878781Glycogen storage disease type IV (GBE1)TAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8982491Glycogen metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22629285Genome-environmental risk assessment of cocaine dependence. (2012)Wei CFront Genet
28355295Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. (2017)Hong EPPLoS One