Gene: HSPB8

26353
CMT2L|DHMN2|E2IG1|H11|HMN2|HMN2A|HSP22
heat shock protein family B (small) member 8
protein-coding
12q24.23
Ensembl:ENSG00000152137 MIM:608014 Vega:OTTHUMG00000168932 UniprotKB:Q9UJY1
NG_007953.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.224e-1 (AD)  2.077e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLU0.895
CD810.865
HADH0.861
FYN0.848
TMBIM60.84
CHPT10.839
CCND30.836
CD590.831
SERP10.826
PCBD10.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.704
OR4F29-0.681
CETP-0.333
FER1L6-0.302
GADL1-0.293
DPPA4-0.27
LY9-0.264
OR52E4-0.26
OR52M1-0.259
MXRA5-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSPB8 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HSPB8 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HSPB8 protein21233418
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of HSPB8 mRNA22841810
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of HSPB8 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HSPB8 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of HSPB8 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of HSPB8 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HSPB8 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSPB8 mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of HSPB8 mRNA17202762
D020106AcrylamideAcrylamide affects the expression of HSPB8 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of HSPB8 mRNA]21233418
C016601afimoxifeneHSPB8 results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HSPB8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HSPB8 mRNA22100608|2715375
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HSPB8 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HSPB8 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HSPB8 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of HSPB8 mRNA26705709
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HSPB8 mRNA"18687144|2535159
D016589AstemizoleAstemizole results in increased expression of HSPB8 mRNA20221588
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of HSPB8 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSPB8 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HSPB8 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSPB8 mRNA21569818|2222880
D004958EstradiolAHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]]22071320
D004958EstradiolAHR protein inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]22071320
D004958EstradiolESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]]22071320
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of HSPB8 mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HSPB8 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSPB8 mRNA19619570
D004958EstradiolEstradiol promotes the reaction [AHR protein binds to HSPB8 promoter]22071320
D004958EstradiolEstradiol promotes the reaction [ARNT protein binds to HSPB8 promoter]22071320
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to HSPB8 promoter]22071320
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of HSPB8 mRNA]20404318
D004958EstradiolEstradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]22071320
D004958Estradiol[Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] which results in decreased expression of HSPB8 mRNA22071320|2207132
D004958EstradiolEstradiol results in increased expression of HSPB8 mRNA19619570|2010694
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]21185374
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of HSPB8 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of HSPB8 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of HSPB8 mRNA23524099|2768578
C006780bisphenol Abisphenol A affects the expression of HSPB8 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of HSPB8 mRNA26496021
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in increased expression of HSPB8 mRNA]19228888
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HSPB8 mRNA14729362
C038091butylparabenbutylparaben results in increased expression of HSPB8 mRNA23524099
D002104CadmiumCadmium results in increased expression of HSPB8 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HSPB8 mRNA22110744
D002220CarbamazepineCarbamazepine affects the expression of HSPB8 mRNA25979313
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HSPB8 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HSPB8 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of HSPB8 mRNA24386269
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of HSPB8 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of HSPB8 mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of HSPB8 mRNA25167922
D019327Copper SulfateCopper Sulfate results in increased expression of HSPB8 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of HSPB8 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of HSPB8 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of HSPB8 mRNA20106945|2556210
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of HSPB8 mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of HSPB8 mRNA29038839
C526360dechlorane plusdechlorane plus results in increased expression of HSPB8 mRNA22913625
C014347decitabinedecitabine affects the expression of HSPB8 mRNA23300844
C016366dibenzothiophenedibenzothiophene results in increased expression of HSPB8 mRNA23656968
D002945CisplatinCisplatin affects the expression of HSPB8 mRNA23300844
D004008DiclofenacDiclofenac results in increased expression of HSPB8 mRNA26934552
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HSPB8 mRNA21318169
D002117CalcitriolCalcitriol results in increased expression of HSPB8 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of HSPB8 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of HSPB8 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HSPB8 mRNA"22485181
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of HSPB8 mRNA24690739
D004237DiuronDiuron results in decreased expression of HSPB8 mRNA21551480
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of HSPB8 mRNA"15919760
C118739entinostatentinostat results in increased expression of HSPB8 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of HSPB8 mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of HSPB8 mRNA29038839
C109476epoxiconazoleepoxiconazole results in increased expression of HSPB8 mRNA29038839
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of HSPB8 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of HSPB8 mRNA21233418
D004967EstrogensEstrogens affects the expression of HSPB822071320
D011345FenofibrateFenofibrate results in increased expression of HSPB8 mRNA21318169
D011345Fenofibrate[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HSPB8 mRNA21318169
D005472FluorouracilFluorouracil results in increased expression of HSPB8 mRNA16557594
D005473FluoxetineFluoxetine results in increased expression of HSPB8 mRNA20924750
D005485FlutamideFlutamide results in increased expression of HSPB8 mRNA24136188
C039281furanfuran results in increased methylation of HSPB8 gene22079235
D019833GenisteinGenistein results in increased expression of HSPB8 mRNA23524099
D017313FenretinideFenretinide results in increased expression of HSPB8 mRNA16671099
C029424hydrazinehydrazine results in increased expression of HSPB8 mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HSPB8 mRNA14729362
D007213IndomethacinIndomethacin results in decreased expression of HSPB8 mRNA28201806
C544151jinfukangjinfukang results in decreased expression of HSPB8 mRNA27392435
C052901lemongrass oillemongrass oil affects the expression of HSPB8 mRNA25976427
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HSPB8 mRNA15919760
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HSPB8 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of HSPB8 mRNA]16415329
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of HSPB8 mRNA16507785
D008694MethamphetamineMethamphetamine results in increased expression of HSPB8 mRNA19564919
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPB8 mRNA]19564919
D008727MethotrexateMethotrexate results in increased expression of HSPB8 mRNA17379860
C002950methylformamidemethylformamide affects the expression of HSPB8 mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of HSPB8 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HSPB8 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HSPB8 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of HSPB8 protein26558463
D008777MethyltestosteroneMethyltestosterone results in increased expression of HSPB8 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of HSPB8 mRNA22108045
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HSPB8 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HSPB8 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of HSPB8 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of HSPB8 mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of HSPB8 mRNA22714537
C012655nimesulidenimesulide results in increased expression of HSPB8 mRNA24136188
C570897NSC668394NSC668394 results in increased expression of HSPB8 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of HSPB8 mRNA20971185
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of HSPB8 mRNA25167922
D010126Ozonepyrazolanthrone promotes the reaction [Ozone results in increased expression of HSPB8 mRNA]17460151
C016030pantogabpantogab results in increased expression of HSPB8 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of HSPB8 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HSPB8 mRNA26705709
D010416PentachlorophenolPentachlorophenol results in increased expression of HSPB8 mRNA23892564
C046012pentanalpentanal results in increased expression of HSPB8 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of HSPB8 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of HSPB8 mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of HSPB8 mRNA22538082
C018637phoronephorone affects the expression of HSPB8 mRNA18198479
C006253pirinixic acidpirinixic acid results in increased expression of HSPB8 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of HSPB8 mRNA20924750
D011192Potassium DichromatePotassium Dichromate results in increased expression of HSPB8 mRNA23608068
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of HSPB8 mRNA29038839
C045362prochlorazprochloraz results in increased expression of HSPB8 mRNA29038839
D011374ProgesteroneProgesterone results in decreased expression of HSPB8 mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HSPB8 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of HSPB8 mRNA20726854
D011372ProgestinsProgestins results in decreased expression of HSPB8 mRNA19609016
C005556propionaldehydepropionaldehyde results in increased expression of HSPB8 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of HSPB8 mRNA27029645
C432165pyrazolanthronepyrazolanthrone promotes the reaction [Ozone results in increased expression of HSPB8 mRNA]17460151
C031280pyrazolepyrazole results in increased expression of HSPB8 mRNA17945193
C030984pyrenepyrene results in increased expression of HSPB8 mRNA23656968
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]21185374
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of HSPB8 mRNA]16415329
C059514resveratrolresveratrol results in increased expression of HSPB8 protein25505154
D012402RotenoneRotenone results in increased expression of HSPB8 mRNA23186747
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSPB8 mRNA"16678137
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPB8 mRNA]19564919
D012715Sesame OilSesame Oil results in decreased expression of HSPB8 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HSPB8 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of HSPB8 mRNA25351596
D012834SilverSilver results in increased expression of HSPB8 mRNA26014281|2895954
D020123SirolimusSirolimus results in decreased expression of HSPB8 protein21233418
C009277sodium arsenatesodium arsenate results in decreased expression of HSPB8 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of HSPB8 mRNA16014739
C016104sodium bichromatesodium bichromate results in increased expression of HSPB8 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of HSPB8 mRNA21340527|2786293
D012999SomanSoman results in increased expression of HSPB8 mRNA19281266
D053260SootSoot results in increased expression of HSPB8 mRNA26551751
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in increased expression of HSPB8 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in increased expression of HSPB8 mRNA19228888
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of HSPB8 mRNA20937368
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of HSPB8 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of HSPB8 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSPB8 mRNA16443690
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSPB8 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSPB8 promoter]22071320
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to HSPB8 promoter]22071320
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to HSPB8 promoter]22071320
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NRIP1 protein binds to HSPB8 promoter]22071320
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] which results in decreased expression of HSPB8 mRNA22071320|2207132
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HSPB8 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HSPB8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSPB8 mRNA19770486|2188995
D013792ThalidomideThalidomide results in decreased expression of HSPB8 mRNA28892372
D013853ThioacetamideThioacetamide results in increased expression of HSPB8 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of HSPB8 mRNA23557971
D014212TretinoinTretinoin results in increased expression of HSPB8 mRNA20117194
D014212TretinoinTretinoin results in decreased expression of HSPB8 mRNA20488242
C011559tributyltintributyltin results in increased expression of HSPB8 mRNA21683754
C012589trichostatin Atrichostatin A results in decreased expression of HSPB8 mRNA15901671
C012589trichostatin Atrichostatin A results in decreased expression of HSPB8 mRNA15901671
C057693troglitazonetroglitazone results in increased expression of HSPB8 mRNA28973697
D014520UrethaneUrethane results in decreased expression of HSPB8 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of HSPB8 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of HSPB8 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPB8 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of HSPB8 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of HSPB8 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of HSPB8 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of HSPB8 mRNA15541757
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of HSPB8 mRNA18579281
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of HSPB8 mRNA18593933
D015034Zinc OxideZinc Oxide analog results in decreased expression of HSPB8 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of HSPB8 mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of HSPB8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activityNOTIDA14985082  
GO:0005515protein binding-IPI14594798  16189514  16225851  21516116  22366786  25036637  
25416956  26496610  28144995  
GO:0042802identical protein binding-IPI14594798  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:1900034regulation of cellular response to heat-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA-  
GO:0005634nucleus-IDA19464326  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA19464326  28144995  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24550170Smoking induces transcription of the heat shock protein system in the joints. (2014 Jul)Ospelt CAnn Rheum Dis