Gene info: ID 2641

Gene: GCG

GENE ID: 2641

Synonyms: GLP-1|GLP1|GLP2|GRPP

Description: glucagon

Gene type: protein-coding

Location: 2q24.2

dbXrefs: Ensembl:ENSG00000115263 MIM:138030 Vega:OTTHUMG00000153892 UniprotKB:P01275

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.032e-2 (AD) 1.750e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PNLIPRP1	0.647
GP2	0.633
CELA3B	0.628
INS	0.626
CPB1	0.621
CTRC	0.617
PLA2G1B	0.603
CTRB1	0.588
CELA3A	0.586
CLPS	0.584

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PCDHGB1	-0.255
PCDHGA4	-0.23
SERPINE3	-0.227
PCDHGA10	-0.208
PCDHGA7	-0.207
BAAT	-0.204
VN1R1	-0.198
SRY	-0.195
SLX4IP	-0.194
SLC35E2B	-0.19

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]"	25787141
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GCG mRNA"	23829299
C538758	2-aminoethyl diphenylborinate	2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
C017759	9-(tetrahydro-2-furyl)-adenine	9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein]	29070885
D000085	Acetates	Acetates results in increased secretion of GCG protein	23341498
D000085	Acetates	GNAT3 protein promotes the reaction [Acetates results in increased secretion of GCG protein]	23341498
D000242	Cyclic AMP	[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP	25191754
D000242	Cyclic AMP	[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [ARRB2 protein binds to GLP1R protein]	25191754
D000242	Cyclic AMP	[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [GRK2 protein binds to GLP1R protein]	25191754
D000242	Cyclic AMP	[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] which affects the localization of ARRB2 protein	25191754
D000242	Cyclic AMP	[GCG protein modified form binds to and results in increased activity of GLP1R protein] which results in increased abundance of Cyclic AMP	18669601
D000242	Cyclic AMP	Dietary Fats promotes the reaction [GCG protein results in increased chemical synthesis of Cyclic AMP]	20074626
D000242	Cyclic AMP	GCG protein results in increased abundance of Cyclic AMP	26964897\|6312992
D000242	Cyclic AMP	GCG protein results in increased chemical synthesis of Cyclic AMP	20074626
D000242	Cyclic AMP	Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]	26964897
D000242	Cyclic AMP	Cyclic AMP affects the susceptibility to GCG protein	6253273
D000242	Cyclic AMP	GCG protein results in increased abundance of Cyclic AMP	6253273
D000242	Cyclic AMP	1-Methyl-3-isobutylxanthine promotes the reaction [GCG protein results in increased abundance of Cyclic AMP]	7505685
D000242	Cyclic AMP	GCG protein results in increased abundance of Cyclic AMP	7505685
D000242	Cyclic AMP	Nicardipine promotes the reaction [GCG protein results in increased abundance of Cyclic AMP]	7505685
D000242	Cyclic AMP	Nifedipine promotes the reaction [GCG protein results in increased abundance of Cyclic AMP]	7505685
D000319	Adrenergic beta-Antagonists	GCG protein alternative form results in decreased susceptibility to Adrenergic beta-Antagonists	9674488
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GCG gene	27153756
D000628	Aminophylline	Aminophylline results in increased secretion of GCG protein	1248788
C014983	amitraz	amitraz results in increased secretion of GCG protein	10582558
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GCG mRNA	16483693
D001564	Benzo(a)pyrene	[Dietary Fats co-treated with Benzo(a)pyrene] results in decreased expression of GCG mRNA	20412841
D001564	Benzo(a)pyrene	[Dietary Fats co-treated with Benzo(a)pyrene] results in decreased expression of GCG protein	20412841
C053541	bicalutamide	bicalutamide results in decreased expression of GCG mRNA	15638997
C006780	bisphenol A	bisphenol A results in decreased expression of GCG mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of GCG gene	28505145
D001786	Blood Glucose	Blood Glucose results in increased secretion of GCG protein	29070885
D001786	Blood Glucose	[GCG protein modified form binds to and results in increased activity of GLP1R protein] which results in decreased abundance of Blood Glucose	18669601
D019819	Budesonide	Budesonide results in decreased expression of GCG mRNA	12524409
D019819	Budesonide	[Fatty Acids co-treated with Budesonide] results in increased expression of GCG mRNA	14705828
D002087	Butyrates	Butyrates results in increased secretion of GCG protein	23341498
D002087	Butyrates	GNAT3 protein promotes the reaction [Butyrates results in increased secretion of GCG protein]	23341498
D020148	Butyric Acid	Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]	27270450
D002118	Calcium	Calcium affects the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D002121	Calcium Channel Blockers	GCG protein alternative form results in decreased susceptibility to Calcium Channel Blockers	9674488
C081643	candesartan	[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]	21255808
C081643	candesartan	[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]	21255808
D002211	Capsaicin	Capsaicin inhibits the reaction [Deoxyglucose results in increased secretion of GCG protein]	1378463
D002217	Carbachol	Carbachol results in increased secretion of GCG protein	3329090
D002217	Carbachol	NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein]	3329090
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GCG protein	12632514
D002251	Carbon Tetrachloride	IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of GCG protein]	12632514
D048271	Chitosan	Chitosan results in increased expression of GCG mRNA	23611362
D048271	Chitosan	Chitosan results in increased secretion of GCG protein	23611362
D048271	Chitosan	SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]	23611362
D048271	Chitosan	SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein]	23611362
D002713	Chlorine	GCG protein results in decreased uptake of Chlorine	1554362
C108217	citronellal	citronellal results in increased secretion of GCG protein	29070885
D002994	Clofibrate	Clofibrate affects the secretion of GCG protein	1143089
D005576	Colforsin	Colforsin promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D005576	Colforsin	Colforsin results in increased secretion of GCG protein	15919803
D003847	Deoxyglucose	Capsaicin inhibits the reaction [Deoxyglucose results in increased secretion of GCG protein]	1378463
D003847	Deoxyglucose	Deoxyglucose results in increased secretion of GCG protein	1378463
C007262	deoxynivalenol	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]"	25787141
C007262	deoxynivalenol	2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
C007262	deoxynivalenol	deoxynivalenol results in increased expression of GCG protein	28633506
C007262	deoxynivalenol	deoxynivalenol results in increased secretion of GCG protein alternative form	25787141
C007262	deoxynivalenol	Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
C007262	deoxynivalenol	Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
C007262	deoxynivalenol	triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
D064791	Desoxycorticosterone Acetate	"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCG mRNA"	22228705
D003907	Dexamethasone	Dexamethasone results in decreased expression of GCG mRNA	12524409
C103490	dexloxiglumide	dexloxiglumide inhibits the reaction [osteum results in increased secretion of GCG protein]	19837920
D003981	Diazoxide	Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]	23200776
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GCG mRNA	21266533
D004026	Dieldrin	Dieldrin results in decreased expression of GCG mRNA	28385952
D004041	Dietary Fats	Dietary Fats results in increased secretion of GCG protein	19837920
D004041	Dietary Fats	orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]	19837920
D004041	Dietary Fats	[Dietary Fats co-treated with Benzo(a)pyrene] results in decreased expression of GCG mRNA	20412841
D004041	Dietary Fats	[Dietary Fats co-treated with Benzo(a)pyrene] results in decreased expression of GCG protein	20412841
D004041	Dietary Fats	Dietary Fats results in decreased expression of GCG mRNA	25016146
D004041	Dietary Fats	Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]	27270450
D004041	Dietary Fats	[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein	27270450
D004041	Dietary Fats	Dietary Fats promotes the reaction [GCG protein results in increased chemical synthesis of Cyclic AMP]	20074626
D004041	Dietary Fats	Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]	27270450
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of GCG mRNA"	27840820
D004533	Egtazic Acid	Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
D004785	Environmental Pollutants	Environmental Pollutants results in decreased secretion of GCG protein	26066519
D004837	Epinephrine	GCG protein results in increased abundance of Epinephrine	3281927
D005227	Fatty Acids	[Fatty Acids co-treated with Budesonide] results in increased expression of GCG mRNA	14705828
D005227	Fatty Acids	Fatty Acids results in increased expression of GCG mRNA	14705828
D005230	Fatty Acids, Nonesterified	"Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GCG protein]"	838844
D005230	Fatty Acids, Nonesterified	"[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GCG protein"	838844
D005231	Fatty Acids, Unsaturated	"[Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA"	14705828
D005421	Flavoring Agents	Flavoring Agents affects the secretion of GCG protein	27890806
D005632	Fructose	GCG protein affects the reaction [Fructose affects the degradation of PKLR mRNA]	2414297
C078049	gatifloxacin	Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]	23200776
C078049	gatifloxacin	gatifloxacin results in increased expression of GCG mRNA	23200776
C078049	gatifloxacin	gatifloxacin results in increased secretion of GCG protein	23200776
C078049	gatifloxacin	[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein	23200776
C078049	gatifloxacin	gatifloxacin results in increased expression of GCG protein	23200776
C078049	gatifloxacin	GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]	23200776
C078049	gatifloxacin	GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]	23200776
C007836	geraniol	9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein]	29070885
C007836	geraniol	CNGA2 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]	29070885
C007836	geraniol	geraniol results in increased secretion of GCG protein	29070885
C007836	geraniol	GNAL mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]	29070885
C007836	geraniol	OR1A1 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]	29070885
C007836	geraniol	OR1G1 mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]	29070885
C007836	geraniol	geraniol results in increased secretion of GCG protein	29070885
D005947	Glucose	"Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GCG protein]"	838844
D005947	Glucose	[GCG protein modified form binds to and results in increased activity of GLP1R protein] promotes the reaction [Glucose results in increased secretion of INS1 protein]	18669601
D005947	Glucose	Glucose results in increased secretion of GCG protein	22479612
D005947	Glucose	isosteviol inhibits the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of GCG protein]]	22479612
D005947	Glucose	Palmitic Acid promotes the reaction [Glucose results in increased secretion of GCG protein]	22479612
D005947	Glucose	[GCG protein modified form binds to and results in increased activity of GLP1R protein] promotes the reaction [Glucose results in increased secretion of INS1 protein]	18669601
D005947	Glucose	GCG results in increased abundance of Glucose	19002567
D005947	Glucose	Glucose results in decreased secretion of GCG protein	12914525
D005947	Glucose	Glucose results in increased secretion of GCG protein	15919803
D005947	Glucose	Metformin inhibits the reaction [GCG results in increased abundance of Glucose]	19002567
D005947	Glucose	troglitazone inhibits the reaction [Glucose results in decreased secretion of GCG protein]	12914525
D005947	Glucose	Zinc inhibits the reaction [Glucose results in increased secretion of GCG protein]	15919803
D005947	Glucose	GCG protein results in increased abundance of Glucose	3019152
D005947	Glucose	Propranolol inhibits the reaction [GCG protein results in increased abundance of Glucose]	3019152
D006854	Hydrocortisone	Hydrocortisone results in increased secretion of GCG protein	12386486
D007213	Indomethacin	Indomethacin results in decreased expression of GCG mRNA	10567023
C051890	irinotecan	irinotecan affects the expression of GCG mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine results in increased secretion of GCG protein	15919803
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine promotes the reaction [GCG protein results in increased abundance of Cyclic AMP]	7505685
C515747	isosteviol	isosteviol inhibits the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of GCG protein]]	22479612
C515747	isosteviol	isosteviol results in increased expression of GCG mRNA	22479612
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides affects the localization of ABCB1 protein]	28842383
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides affects the localization of ABCC2 protein]	28842383
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCB1 mRNA]	28842383
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCC2 mRNA]	28842383
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of ABCB1 protein]	28842383
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of ABCC2 protein]	28842383
D008070	Lipopolysaccharides	GCG protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]	28842383
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [HDAC1 protein binds to GCG promoter]	19582394
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [TCF7L2 protein binds to GCG promoter]	19582394
D018021	Lithium Chloride	Lithium Chloride promotes the reaction [CTNNB1 protein binds to GCG promoter]	19582394
D018021	Lithium Chloride	Lithium Chloride promotes the reaction [LEF1 protein binds to GCG promoter]	19582394
D018021	Lithium Chloride	Lithium Chloride promotes the reaction [[LEF1 protein co-treated with CTNNB1 protein] binds to GCG promoter]	19582394
D018021	Lithium Chloride	Lithium Chloride results in increased expression of GCG mRNA	19582394
D008095	Lithocholic Acid	GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein]	23341498
D008095	Lithocholic Acid	Lithocholic Acid results in increased secretion of GCG protein	23341498
C013592	mangiferin	[mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of GCG protein alternative form	22948814
C013592	mangiferin	mangiferin binds to GCG protein	20236857
D008687	Metformin	[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA	22117073
D008687	Metformin	Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]	23166782
D008687	Metformin	Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]	22117073
D008687	Metformin	Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]	23166782
D008687	Metformin	Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]	22117073
D008687	Metformin	Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]	27270450
D008687	Metformin	Metformin inhibits the reaction [GCG results in increased abundance of Glucose]	19002567
D008787	Metoclopramide	Metoclopramide results in increased secretion of GCG protein	20829521
C570834	MK0626	MK0626 inhibits the reaction [Tacrolimus results in decreased secretion of GCG protein modified form]	24959755
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased secretion of INS1 protein]	16837018
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]	26964897
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]	26964897
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]	26964897
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]	26964897
D009525	Niacin	"Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GCG protein]"	838844
D009525	Niacin	"[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GCG protein"	838844
D009529	Nicardipine	Nicardipine promotes the reaction [GCG protein results in increased abundance of Cyclic AMP]	7505685
D009534	Niclosamide	Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]	26964897
D009534	Niclosamide	Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]	26964897
D009534	Niclosamide	Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]	26964897
D009534	Niclosamide	Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]	26964897
D009534	Niclosamide	Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]	26964897
D009543	Nifedipine	Nifedipine promotes the reaction [GCG protein results in increased abundance of Cyclic AMP]	7505685
D009568	Nitrendipine	Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
D019301	Oleic Acid	GNAT3 protein promotes the reaction [Oleic Acid results in increased secretion of GCG protein]	23341498
D019301	Oleic Acid	Oleic Acid results in increased secretion of GCG protein	23341498
D015282	Octreotide	Octreotide results in decreased activity of GCG protein	18463367
C488250	oleoylethanolamide	GNAT3 protein promotes the reaction [oleoylethanolamide results in increased secretion of GCG protein]	23341498
C488250	oleoylethanolamide	oleoylethanolamide results in increased secretion of GCG protein	23341498
D000069463	Olive Oil	Olive Oil results in increased secretion of GCG protein	19837920
D000069463	Olive Oil	orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]	19837920
C055122	orlistat	orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]	19837920
C055122	orlistat	orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]	19837920
C055122	orlistat	orlistat results in decreased expression of GCG protein	12915676
C055122	orlistat	orlistat results in decreased secretion of GCG protein	18647814
C013173	osteum	dexloxiglumide inhibits the reaction [osteum results in increased secretion of GCG protein]	19837920
C013173	osteum	osteum results in increased secretion of GCG protein	19837920
D019308	Palmitic Acid	[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]	21255808
D019308	Palmitic Acid	[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]	21255808
D019308	Palmitic Acid	GCG protein inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]	21255808
D019308	Palmitic Acid	GCG protein inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]	21255808
D019308	Palmitic Acid	isosteviol inhibits the reaction [Palmitic Acid promotes the reaction [Glucose results in increased secretion of GCG protein]]	22479612
D019308	Palmitic Acid	Palmitic Acid promotes the reaction [Glucose results in increased secretion of GCG protein]	22479612
D019308	Palmitic Acid	Palmitic Acid results in increased expression of GCG mRNA	22479612
D010575	Pesticides	Pesticides results in increased secretion of GCG protein	25463530
D010575	Pesticides	PON1 protein polymorphism affects the reaction [Pesticides results in increased secretion of GCG protein]	25463530
D010728	Phosphoenolpyruvate	GCG protein affects the abundance of Phosphoenolpyruvate	747652
C006253	pirinixic acid	pirinixic acid results in decreased expression of GCG mRNA	17950772
D028321	Plant Preparations	Plant Preparations results in increased expression of GCG protein modified form	21907189
D011188	Potassium	GCG protein results in increased uptake of Potassium	1554362
D011189	Potassium Chloride	"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCG mRNA"	22228705
D011241	Prednisone	"[Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA"	14705828
D011241	Prednisone	Prednisone results in decreased expression of GCG mRNA	12524409
D011433	Propranolol	Propranolol inhibits the reaction [GCG protein results in increased abundance of Glucose]	3019152
D019289	Pyruvic Acid	1-Methyl-3-isobutylxanthine promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D019289	Pyruvic Acid	Calcium affects the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D019289	Pyruvic Acid	Colforsin promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D019289	Pyruvic Acid	INS protein inhibits the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D019289	Pyruvic Acid	Pyruvic Acid results in increased secretion of GCG protein	15919803
D019289	Pyruvic Acid	Zinc inhibits the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of GCG mRNA]	18998217
C093642	SB 203580	SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]	23611362
C093642	SB 203580	SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein]	23611362
D012834	Silver	Silver analog results in decreased expression of GCG mRNA	22727896
C439060	sirtinol	[sirtinol binds to and results in decreased activity of SIRT1 protein] promotes the reaction [GCG protein results in increased acetylation of CRTC2 protein]	18849969
D000068900	Sitagliptin Phosphate	[mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of GCG protein alternative form	22948814
D000068900	Sitagliptin Phosphate	Sitagliptin Phosphate inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA]	23466488
D012964	Sodium	[Sodium co-treated with GCG protein] results in increased secretion of INS1 protein	16837018
D012964	Sodium	triphenyltin chloride inhibits the reaction [[Sodium co-treated with GCG protein] results in increased secretion of INS1 protein]	16837018
D017673	Sodium Chloride, Dietary	"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GCG mRNA"	22228705
C525422	SRT1720	[SRT1720 results in increased activity of SIRT1 protein] inhibits the reaction [GCG protein results in increased expression of CRTC2 protein modified form]	18849969
D013311	Streptozocin	Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]	27270450
D013311	Streptozocin	[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein	27270450
D013311	Streptozocin	Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]	27270450
D013311	Streptozocin	rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of GCG mRNA]	18998217
D013311	Streptozocin	Sitagliptin Phosphate inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA]	23466488
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA	23466488
D013311	Streptozocin	Streptozocin results in decreased expression of GCG mRNA	18998217
D016559	Tacrolimus	MK0626 inhibits the reaction [Tacrolimus results in decreased secretion of GCG protein modified form]	24959755
D016559	Tacrolimus	Tacrolimus results in decreased secretion of GCG protein modified form	24959755
D000068581	Tadalafil	Tadalafil results in decreased activity of GCG protein	24911673
D013726	Terbutaline	NPY protein inhibits the reaction [Terbutaline results in increased secretion of GCG protein]	3329090
D013726	Terbutaline	Terbutaline results in increased secretion of GCG protein	3329090
D014044	Tolbutamide	Tolbutamide results in increased secretion of GCG protein	15919803
D014212	Tretinoin	Tretinoin results in increased expression of GCG protein	16473924
C063888	triphenylphosphine oxide	triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]	25787141
C012594	triphenyltin chloride	triphenyltin chloride inhibits the reaction [GCG protein results in increased secretion of INS1 protein]	16837018
C012594	triphenyltin chloride	triphenyltin chloride inhibits the reaction [[Sodium co-treated with GCG protein] results in increased secretion of INS1 protein]	16837018
C057693	troglitazone	troglitazone inhibits the reaction [Glucose results in decreased secretion of GCG protein]	12914525
C025699	U 40481	U 40481 results in increased secretion of GCG protein	10582558
D014635	Valproic Acid	Valproic Acid results in decreased methylation of GCG gene	29154799
C025643	vinclozolin	vinclozolin results in decreased expression of GCG mRNA	23869203
D014801	Vitamin A	[Vitamin A co-treated with INHBA protein] results in increased expression of GCG mRNA	17244017
D009536	Niacinamide	Sitagliptin Phosphate inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA]	23466488
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA	23466488
C102817	voglibose	voglibose results in increased expression of GCG mRNA	19208898
C102817	voglibose	voglibose results in increased expression of GCG protein	19208898
C102817	voglibose	voglibose results in increased secretion of GCG protein	19208898
D015032	Zinc	Zinc results in decreased secretion of GCG protein	18250168
D015032	Zinc	Zinc inhibits the reaction [Glucose results in increased secretion of GCG protein]	15919803
D015032	Zinc	Zinc inhibits the reaction [Pyruvic Acid results in increased secretion of GCG protein]	15919803
D015032	Zinc	Zinc results in decreased secretion of GCG protein	15919803

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	9990065
GO:0005179	hormone activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	17051221 17715056 21314817
GO:0031769	glucagon receptor binding	-	IBA	21873635
GO:0042802	identical protein binding	-	IPI	22212535

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	7929237
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007631	feeding behavior	-	TAS	8538742
GO:0008283	cell proliferation	-	TAS	10861272
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010737	protein kinase A signaling	-	IBA	21873635
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	-	IEA	-
GO:0032092	positive regulation of protein binding	-	IEA	-
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	IEA	-
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	-	IBA	21873635
GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0045860	positive regulation of protein kinase activity	-	IEA	-
GO:0050796	regulation of insulin secretion	-	TAS	-
GO:0051571	positive regulation of histone H3-K4 methylation	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0071377	cellular response to glucagon stimulus	-	TAS	-
GO:0090280	positive regulation of calcium ion import	-	IEA	-
GO:1900118	negative regulation of execution phase of apoptosis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0034774	secretory granule lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-163359	Glucagon signaling in metabolic regulation	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-2980736	Peptide hormone metabolism	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	IEA
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	TAS
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-400508	Incretin synthesis, secretion, and inactivation	TAS
R-HSA-400508	Incretin synthesis, secretion, and inactivation	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-420092	Glucagon-type ligand receptors	TAS
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	TAS
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
2008995	Gcglobulin functions as a cochemotaxin in the lower respiratory tract. A potential mechanism for lung neutrophil recruitment in cigarette smokers. (1991 Apr)	Metcalf JP	Am Rev Respir Dis
24185078	Glucagon gene polymorphism modifies the effects of smoking and physical activity on risk of type 2 diabetes mellitus in Han Chinese. (2014 Jan 25)	Li L	Gene
2221580	Inactivation of chemotactic factor inactivator by cigarette smoke. A potential mechanism of modulating neutrophil recruitment to the lung. (1990 Oct)	Robbins RA	Am Rev Respir Dis
22488871	ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. (2012 Jun)	Hill SY	Am J Med Genet B Neuropsychiatr Genet