Gene: GCH1

2643
DYT14|DYT5|DYT5a|GCH|GTP-CH-1|GTPCH1|HPABH4B
GTP cyclohydrolase 1
protein-coding
14q22.2
Ensembl:ENSG00000131979 MIM:600225 Vega:OTTHUMG00000029754 UniprotKB:P30793
NG_008647.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.003e-1 (AD)  5.612e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VCAM10.764
IRF10.757
NLRC50.757
APOL30.738
APOL10.731
GBP10.729
SP1000.727
ISG200.726
SIGLEC50.724
PARP120.724

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PVALB-0.339
SCRT1-0.337
NEUROD2-0.332
MYADML2-0.325
SLC6A7-0.321
SOHLH1-0.31
EMX1-0.31
GALNT9-0.306
DBH-0.305
NEUROD6-0.304

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02325Isopropyl AlcoholSmall Molecule67-63-0Approved|InvestigationalTarget
DB02377GuanineSmall Molecule73-40-5ExperimentalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCH1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCH1 mRNA]"27071940
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GCH1 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GCH1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GCH1 mRNA"25614096
C0172022,4-diaminohypoxanthine"[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Acetylcholine"12855421
C0172022,4-diaminohypoxanthine"[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Calcimycin"12855421
C0172022,4-diaminohypoxanthine"2,4-diaminohypoxanthine results in decreased expression of GCH1 protein"12855421
C0172022,4-diaminohypoxanthine"sepiapterin inhibits the reaction [[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Calcimycin]"12855421
C0172022,4-diaminohypoxanthine"2,4-diaminohypoxanthine inhibits the reaction [[GCH1 protein co-treated with Guanosine Triphosphate] results in increased chemical synthesis of sapropterin]"7756597
C0172022,4-diaminohypoxanthine"2,4-diaminohypoxanthine results in decreased activity of GCH1 protein"7756597
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of GCH1 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GCH1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GCH1 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of GCH1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCH1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased activity of GCH1 protein17872449
C0275764-hydroxy-2-nonenal[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin17872449
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased degradation of GCH1 protein17872449
C0275764-hydroxy-2-nonenalAscorbic Acid inhibits the reaction [[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin]17872449
C0275764-hydroxy-2-nonenalAscorbic Acid inhibits the reaction [4-hydroxy-2-nonenal results in increased degradation of GCH1 protein]17872449
C0275764-hydroxy-2-nonenallactacystin inhibits the reaction [[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin]17872449
C0275764-hydroxy-2-nonenallactacystin inhibits the reaction [4-hydroxy-2-nonenal results in increased degradation of GCH1 protein]17872449
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCH1 mRNA"27188386
C0172267,8-dihydrobiopterin"EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]"25490417
C0172267,8-dihydrobiopterin"GCH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin"25490417
C0172267,8-dihydrobiopterin"[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin"25490417
D000082AcetaminophenAcetaminophen results in increased expression of GCH1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of GCH1 mRNA17562736
D000109AcetylcholineEPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine]25490417
D000109AcetylcholineGCH1 gene mutant form results in decreased susceptibility to Acetylcholine25490417
D000109Acetylcholine"[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Acetylcholine"12855421
D019798NeopterinEPO protein promotes the reaction [GCH1 protein results in increased chemical synthesis of Neopterin]25490417
D019798NeopterinGCH1 protein results in increased chemical synthesis of Neopterin25490417
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GCH1 mRNA16483693
D000968Antimycin AAntimycin A results in increased expression of GCH1 mRNA19304788
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GCH1 mRNA24449571
D001151ArsenicArsenic affects the methylation of GCH1 gene25304211
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin]17872449
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [4-hydroxy-2-nonenal results in increased degradation of GCH1 protein]17872449
D001280AtrazineAtrazine affects the expression of GCH1 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GCH1 mRNA23656968
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GCH1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GCH1 mRNA22228805
D004958EstradiolEstradiol affects the expression of GCH1 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of GCH1 mRNA20404318
C044887beta-methylcholinebeta-methylcholine affects the expression of GCH1 mRNA21179406
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of GCH1 mRNA15912405
C006780bisphenol Abisphenol A results in increased expression of GCH1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of GCH1 mRNA22434021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GCH1 mRNA18804290
C018475butyraldehydebutyraldehyde results in increased expression of GCH1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of GCH1 mRNA22110744
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GCH1 mRNA20360939
D000001Calcimycin"[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Calcimycin"12855421
D000001Calcimycin"sepiapterin inhibits the reaction [[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Calcimycin]"12855421
D002211CapsaicinGCH1 gene SNP affects the susceptibility to Capsaicin19081190
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GCH1 mRNA27339419
C031180chrysenechrysene results in decreased expression of GCH1 mRNA26377693
C418118CI 1044CI 1044 results in increased expression of GCH1 mRNA17569694
D002994ClofibrateClofibrate results in decreased expression of GCH1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of GCH1 mRNA24386269
D003078ColchicineColchicine results in decreased expression of GCH1 mRNA24211769
D019327Copper SulfateCopper Sulfate results in decreased expression of GCH1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GCH1 mRNA20106945|2556210
C093628cyproconazolecyproconazole results in increased expression of GCH1 mRNA22334560
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GCH1 mRNA23640034
C014347decitabinedecitabine results in increased expression of GCH1 mRNA19151715|1919447
D003907DexamethasoneDexamethasone results in decreased expression of GCH1 mRNA11368234
D003976DiazinonDiazinon results in increased methylation of GCH1 gene22964155
D003976DiazinonDiazinon affects the expression of GCH1 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GCH1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GCH1 mRNA24211769
D002945CisplatinCisplatin results in increased expression of GCH1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of GCH1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of GCH1 mRNA15238619|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GCH1 mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GCH1 mRNA17005392
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]15659429
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]15659429
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]15659429
D004298DopamineGCH1 protein results in increased abundance of Dopamine15929554
C109476epoxiconazoleepoxiconazole results in increased expression of GCH1 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GCH1 mRNA17108234
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GCH1 mRNA15576828|1755790
C024565ethylene dichlorideethylene dichloride results in decreased expression of GCH1 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GCH1 mRNA24211769
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GCH1 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of GCH1 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GCH1 mRNA28329830
D005485FlutamideFlutamide results in increased expression of GCH1 mRNA24136188
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of GCH1 mRNA24657277
D005557FormaldehydeFormaldehyde results in increased expression of GCH1 mRNA23649840
C070081fulvestrantfulvestrant inhibits the reaction [resveratrol results in increased expression of GCH1 protein]17666920
C039281furanfuran results in increased methylation of GCH1 gene22079235
D005978GlutathioneGlutathione deficiency results in increased expression of GCH1 mRNA15345336
D006152Cyclic GMPCAT protein inhibits the reaction [GCH1 gene mutant form results in increased abundance of Cyclic GMP]25490417
D006152Cyclic GMPEPO protein inhibits the reaction [GCH1 gene mutant form results in increased abundance of Cyclic GMP]25490417
D006152Cyclic GMPGCH1 gene mutant form results in increased abundance of Cyclic GMP25490417
D006152Cyclic GMPGCH1 protein affects the abundance of Cyclic GMP21963838
D006160Guanosine Triphosphate"2,4-diaminohypoxanthine inhibits the reaction [[GCH1 protein co-treated with Guanosine Triphosphate] results in increased chemical synthesis of sapropterin]"7756597
D006160Guanosine Triphosphate[GCH1 protein co-treated with Guanosine Triphosphate] results in increased chemical synthesis of sapropterin7756597
C425931GW 501516GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein]22886847
D017313FenretinideFenretinide results in decreased expression of GCH1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of GCH1 mRNA28973697
D006861Hydrogen PeroxideEPO protein inhibits the reaction [GCH1 gene mutant form results in increased abundance of Hydrogen Peroxide]25490417
D006861Hydrogen PeroxideGCH1 gene mutant form results in increased abundance of Hydrogen Peroxide25490417
D006861Hydrogen PeroxideGCH1 protein affects the abundance of Hydrogen Peroxide21963838
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GCH1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GCH1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of GCH1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GCH1 mRNA23430699|2479639
C067713lactacystinlactacystin inhibits the reaction [[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin]17872449
C067713lactacystinlactacystin inhibits the reaction [4-hydroxy-2-nonenal results in increased degradation of GCH1 protein]17872449
C008261lead acetatelead acetate results in increased expression of GCH1 mRNA25270620
C008261lead acetatelead acetate results in decreased expression of GCH1 mRNA22641619
D001556LindaneLindane results in increased expression of GCH1 mRNA18804290
C433788lipopolysaccharide, E. coli O26-B6"[lipopolysaccharide, E. coli O26-B6 co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCH1 mRNA"12566086
C433788lipopolysaccharide, E. coli O26-B6"rosiglitazone inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCH1 mRNA]"12566086
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GCH1 mRNA25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GCH1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GCH1 protein18634867
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GCH1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCH1 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of GCH1 mRNA19564919
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of GCH1 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of GCH1 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GCH1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GCH1 mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GCH1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GCH1 mRNA24211769
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GCH1 mRNA23649840
D008774MethylphenidateMethylphenidate results in decreased expression of GCH1 mRNA22470460
D016685MitomycinMitomycin results in decreased expression of GCH1 mRNA24211769
D008942MitoxantroneGCH1 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GCH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GCH1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GCH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GCH1 mRNA"25554681
D009281NaphthalenesNaphthalenes results in increased expression of GCH1 protein17337753
C017096n-butoxyethanoln-butoxyethanol results in increased expression of GCH1 mRNA19812364
C051752nefazodonenefazodone results in increased expression of GCH1 mRNA24136188
D009532NickelNickel results in increased expression of GCH1 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of GCH1 mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of GCH1 mRNA19167457
D009538NicotineNicotine results in increased expression of GCH1 mRNA16949557
C012655nimesulidenimesulide results in increased expression of GCH1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GCH1 mRNA17616710
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]15659429
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]15659429
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]15659429
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GCH1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of GCH1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of GCH1 mRNA26516004
D010126OzoneOzone results in increased expression of GCH1 mRNA17095637
D010269ParaquatParaquat results in increased expression of GCH1 mRNA20388547
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of GCH1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GCH1 mRNA26705709
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GCH1 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GCH1 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of GCH1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GCH1 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of GCH1 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of GCH1 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GCH1 mRNA19162173
C024273profenofosprofenofos results in decreased expression of GCH1 mRNA17569032
D011374ProgesteroneProgesterone results in increased expression of GCH1 mRNA19246319
C045950propiconazolepropiconazole results in increased expression of GCH1 mRNA22334560
C010313pseudocumenepseudocumene results in increased expression of GCH1 protein17337753
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA]12832416
D012110ReserpineReserpine results in increased expression of GCH1 mRNA8103077
D012110ReserpineReserpine results in increased expression of GCH1 mRNA alternative form8103077
C059514resveratrolresveratrol results in increased expression of GCH120610621
C059514resveratrolresveratrol results in increased expression of GCH1 mRNA20610621
C059514resveratrol[resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin20610621
C059514resveratrolfulvestrant inhibits the reaction [resveratrol results in increased expression of GCH1 protein]17666920
C059514resveratrolresveratrol results in increased expression of GCH1 protein17666920
C089730rosiglitazone"rosiglitazone inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 co-treated with TNF protein co-treated with IFNG protein] results in increased expression of GCH1 mRNA]"12566086
D012402RotenoneRotenone results in increased expression of GCH1 mRNA19304788
D012402RotenoneRotenone results in decreased expression of GCH1 mRNA19013527
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of GCH1 mRNA21427059
C003402sapropterin[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin17872449
C003402sapropterinAscorbic Acid inhibits the reaction [[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin]17872449
C003402sapropterinlactacystin inhibits the reaction [[4-hydroxy-2-nonenal results in decreased activity of GCH1 protein] which results in decreased chemical synthesis of sapropterin]17872449
C003402sapropterinEPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]25041251
C003402sapropterinGCH1 mutant form results in decreased abundance of sapropterin25041251
C003402sapropterinGCH1 protein results in increased chemical synthesis of sapropterin14551046
C003402sapropterin"EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]"25490417
C003402sapropterinGCH1 gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin25490417
C003402sapropterin"[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin"25490417
C003402sapropterinGCH1 protein affects the abundance of sapropterin21963838
C003402sapropterin[resveratrol results in increased expression of GCH1 mRNA] which results in increased abundance of sapropterin20610621
C003402sapropterin"2,4-diaminohypoxanthine inhibits the reaction [[GCH1 protein co-treated with Guanosine Triphosphate] results in increased chemical synthesis of sapropterin]"7756597
C003402sapropterinGCH1 protein affects the chemical synthesis of sapropterin20610621
C003402sapropterin[GCH1 protein co-treated with Guanosine Triphosphate] results in increased chemical synthesis of sapropterin7756597
C003402sapropterinGCH1 protein results in increased chemical synthesis of sapropterin11368234
D012524SarinSarin results in decreased expression of GCH1 mRNA19522546
C016727sepiapterin"sepiapterin inhibits the reaction [[2,4-diaminohypoxanthine results in decreased activity of GCH1 protein] which affects the susceptibility to Calcimycin]"12855421
C009250sevofluranesevoflurane affects the expression of GCH1 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GCH1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of GCH1 mRNA19073995
D012822Silicon DioxideSilicon Dioxide results in increased expression of GCH1 mRNA22431001
D012834SilverSilver results in decreased expression of GCH1 mRNA27131904
D012906SmokeSmoke affects the expression of GCH1 mRNA23693141
C016104sodium bichromatesodium bichromate results in increased expression of GCH1 mRNA22561333
C016104sodium bichromatesodium bichromate results in decreased expression of GCH1 mRNA22561333
D012999SomanSoman results in increased expression of GCH1 mRNA19281266
D053260SootSoot results in increased expression of GCH1 mRNA22461453|2655175
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of GCH1 mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GCH1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCH1 mRNA26378955
D013481SuperoxidesGCH1 protein affects the abundance of Superoxides21963838
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of GCH1 mRNA"26680231
D014284TriiodothyronineTriiodothyronine results in increased expression of GCH1 mRNA15953391
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GCH1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GCH1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GCH1 mRNA18691609|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GCH1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GCH1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of GCH1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GCH1 mRNA20133372
D019772TopotecanGCH1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GCH1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of GCH1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of GCH1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of GCH1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of GCH1 mRNA24935251
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of GCH1 mRNA17982090
C022884undecaneundecane results in increased expression of GCH1 protein17337753
D014520UrethaneUrethane results in increased expression of GCH1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GCH1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GCH1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GCH1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of GCH1 mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of GCH1 mRNA23869203
C029297vinylidene chloridevinylidene chloride results in increased expression of GCH1 mRNA26682919
D000225AdenineAdenine results in decreased expression of GCH1 mRNA24211769
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of GCH1 mRNA18593933
D015034Zinc OxideZinc Oxide analog results in decreased expression of GCH1 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of GCH1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA2463916  
GO:0003934GTP cyclohydrolase I activity-IBA21873635  
GO:0003934GTP cyclohydrolase I activity-IDA7730309  7874165  16778797  
GO:0003934GTP cyclohydrolase I activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI9092499  16696853  19294699  21988832  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IDA3753653  14717702  
GO:0008270zinc ion binding-IBA21873635  
GO:0008270zinc ion binding-IDA11087827  14717702  
GO:0030742GTP-dependent protein binding-IEA-  
GO:0031369translation initiation factor binding-IEA-  
GO:0042803protein homodimerization activity-IPI16696853  
GO:0050662coenzyme binding-IEA-  
GO:0051019mitogen-activated protein kinase binding-IPI19294699  
GO ID GO Term Qualifier Evidence PubMed
GO:0006729tetrahydrobiopterin biosynthetic process-IBA21873635  
GO:0006729tetrahydrobiopterin biosynthetic process-IDA7678411  9445252  
GO:0006729tetrahydrobiopterin biosynthetic process-IMP17101830  19666465  
GO:0006809nitric oxide biosynthetic process-NAS9445252  
GO:0008217regulation of blood pressure-IMP17717598  
GO:0010460positive regulation of heart rate-IEA-  
GO:0014916regulation of lung blood pressure-IEA-  
GO:0032496response to lipopolysaccharide-IDA7678411  9445252  
GO:0032496response to lipopolysaccharideNOTIEP15604419  
GO:0034341response to interferon-gamma-IDA7678411  9445252  12607127  
GO:0034612response to tumor necrosis factor-IDA9445252  
GO:00359987,8-dihydroneopterin 3'-triphosphate biosynthetic process-IEA-  
GO:0042311vasodilation-IEA-  
GO:0042416dopamine biosynthetic process-IDA16338639  
GO:0042559pteridine-containing compound biosynthetic process-IDA2463916  3753653  15721862  
GO:0045776negative regulation of blood pressure-IEA-  
GO:0046654tetrahydrofolate biosynthetic process-IEA-  
GO:0048265response to pain-ISS-  
GO:0050884neuromuscular process controlling posture-IMP7874165  
GO:0051000positive regulation of nitric-oxide synthase activity-IDA12176133  15721862  
GO:0051000positive regulation of nitric-oxide synthase activity-IMP17717598  19666465  
GO:0051186cofactor metabolic process-TAS-  
GO:0051260protein homooligomerization-IDA11087827  
GO:0051291protein heterooligomerization-IEA-  
GO:2000121regulation of removal of superoxide radicals-IMP19666465  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16778797  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10907721  
GO:0005829cytosol-IDA2463916  3318829  
GO:0005829cytosol-TAS-  
GO:0031410cytoplasmic vesicle-IDA3318829  
GO:0031965nuclear membrane-IDA-  
GO:0032991protein-containing complex-IDA11087823  
GO:0044306neuron projection terminus-TAS23457032  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-8978934Metabolism of cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23365103SGCE mutations cause psychiatric disorders: clinical and genetic characterization. (2013 Jan)Peall KJBrain