Gene: AMELX

265
AI1E|AIH1|ALGN|AMG|AMGL|AMGX
amelogenin X-linked
protein-coding
Xp22.2
Ensembl:ENSG00000125363 MIM:300391 Vega:OTTHUMG00000021130 UniprotKB:Q99217
NG_012040.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MEP1B0.414
CXorf51A0.391
HES70.361
DLX40.353
CDH30.337
MRGPRX40.334
KRTAP5-30.331
MTNR1A0.331
ANKRD330.325
PYY0.323

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSE-0.241
WSCD1-0.213
KCNJ16-0.194
NWD1-0.191
C9orf57-0.187
CCDC160-0.186
ZBED6-0.184
DHFR-0.184
ZFP3-0.183
OR1G1-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of AMELX mRNA"15215175
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of AMELX mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AMELX mRNA]17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMELX mRNA16483693
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of AMELX mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of AMELX mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of AMELX mRNA27257137
C006780bisphenol Abisphenol A results in increased expression of AMELX protein27257137
D002104CadmiumCadmium results in decreased expression of AMELX mRNA24376830
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of AMELX mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AMELX mRNA]17585979
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of AMELX mRNA23914054
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of AMELX mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AMELX mRNA26924002
C070609EMD 53998EMD 53998 analog results in decreased expression of AMELX mRNA24977338
D005473FluoxetineFluoxetine results in decreased expression of AMELX mRNA21083617
D008713MethimazoleMethimazole results in decreased expression of AMELX mRNA22504374
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AMELX mRNA26924002
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of AMELX mRNA12832660
C006253pirinixic acidpirinixic acid results in decreased expression of AMELX mRNA23811191
D059808PolyphenolsPolyphenols results in decreased expression of AMELX mRNA16293270
D011441PropylthiouracilPropylthiouracil results in decreased expression of AMELX mRNA22504374
C017947sodium arsenitesodium arsenite results in increased expression of AMELX mRNA19072884
D012969Sodium FluorideSodium Fluoride results in increased expression of AMELX mRNA27257137
D012969Sodium FluorideSodium Fluoride results in increased expression of AMELX protein27257137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AMELX mRNA26377647
D014212TretinoinTretinoin results in increased expression of AMELX mRNA28689802
D014635Valproic AcidValproic Acid results in decreased methylation of AMELX gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AMELX gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18434575  
GO:0008083growth factor activity-ISS1734713  
GO:0030345structural constituent of tooth enamel-IDA1734713  2509010  
GO:0030345structural constituent of tooth enamel-IMP1483698  
GO:0042802identical protein binding-ISS1734713  
GO:0046848hydroxyapatite binding-ISS1734713  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-ISS1734713  
GO:0001837epithelial to mesenchymal transition-ISS1734713  
GO:0002062chondrocyte differentiation-ISS1734713  
GO:0007155cell adhesion-ISS1734713  
GO:0007165signal transduction-TAS16674683  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031214biomineral tissue development-TAS2509010  
GO:0032967positive regulation of collagen biosynthetic process-ISS1734713  
GO:0034505tooth mineralization-IMP1483698  
GO:0034505tooth mineralization-ISS1734713  
GO:0042127regulation of cell proliferation-ISS1734713  
GO:0042475odontogenesis of dentin-containing tooth-ISS1734713  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0070166enamel mineralization-IMP1916828  
GO:0070172positive regulation of tooth mineralization-TAS2509010  
GO ID GO Term Qualifier Evidence PubMed
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0009986cell surface-ISS1734713  
GO:0062023collagen-containing extracellular matrix-IDA2509010  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28266114Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. (2017 Mar)Chapple ILJ Clin Periodontol