Gene: GCNT2

2651
CCAT|CTRCT13|GCNT2C|GCNT5|IGNT|II|NACGT1|NAGCT1|ULG3|bA360O19.2|bA421M1.1
glucosaminyl (N-acetyl) transferase 2 (I blood group)
protein-coding
6p24.3-p24.2
Ensembl:ENSG00000111846 MIM:600429 Vega:OTTHUMG00000014244 UniprotKB:Q8N0V5
NG_007469.3
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.162e-2 (AD)  8.802e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6913109chr6:10607699 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F20.769
MAP3K10.688
CCDC500.669
BACH10.647
PDE5A0.639
CCND10.638
PCDH180.635
JAG10.635
SEMA5A0.633
RBMS30.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBA2-0.416
FEZF2-0.415
TMEM191C-0.41
FGF22-0.402
PNPLA7-0.384
ADTRP-0.384
MYADML2-0.377
ITGA2B-0.376
GPR150-0.368
RHO-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GCNT2 mRNA"28903501
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GCNT2 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GCNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GCNT2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GCNT2 mRNA21420995|2906747
D020106AcrylamideAcrylamide results in decreased expression of GCNT2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GCNT2 mRNA19770486
D001151ArsenicArsenic results in decreased expression of GCNT2 mRNA19654921
C015001arsenitearsenite results in increased methylation of GCNT2 promoter23974009
D001374AzacitidineAzacitidine results in decreased expression of GCNT2 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GCNT2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GCNT2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GCNT2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GCNT2 mRNA21839799
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GCNT2 mRNA20823114
C006780bisphenol Abisphenol A results in increased expression of GCNT2 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of GCNT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GCNT2 gene28505145
D000069286BortezomibBortezomib results in increased expression of GCNT2 mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GCNT2 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GCNT2 mRNA17484886
D019327Copper SulfateCopper Sulfate results in increased expression of GCNT2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of GCNT2 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of GCNT2 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of GCNT2 mRNA21198554
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GCNT2 mRNA23640034
D013759DronabinolDronabinol results in decreased expression of GCNT2 mRNA21955143
D003907DexamethasoneDexamethasone results in increased expression of GCNT2 mRNA22733784
D003976DiazinonDiazinon results in increased methylation of GCNT2 gene22964155
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GCNT2 mRNA20823114
D002945CisplatinGCNT2 protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of GCNT2 mRNA28031460
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GCNT2 mRNA19638242
D004237DiuronDiuron results in decreased expression of GCNT2 mRNA25152437
D004642EmodinEmodin results in increased expression of GCNT2 mRNA15612046
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GCNT2 mRNA22079256
D000431EthanolEthanol results in decreased expression of GCNT2 mRNA21955143
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GCNT2 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of GCNT2 mRNA20655997|2364984
C039281furanfuran results in increased expression of GCNT2 mRNA24183702
D005897GlafenineGlafenine results in increased expression of GCNT2 mRNA24136188
C004312glycidolglycidol results in decreased expression of GCNT2 mRNA24915197
D017313FenretinideFenretinide results in increased expression of GCNT2 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of GCNT2 mRNA20003209
D007608Kainic AcidKainic Acid results in increased expression of GCNT2 mRNA17997037
D048628KetolidesKetolides analog results in increased expression of GCNT2 mRNA24967691
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of GCNT2 mRNA20823114
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GCNT2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GCNT2 mRNA"20188158
D009020MorphineMorphine results in increased expression of GCNT2 mRNA21955143
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of GCNT2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GCNT2 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of GCNT2 mRNA22714537
D009538NicotineNicotine results in decreased expression of GCNT2 mRNA21955143
D009538NicotineNicotine results in increased expression of GCNT2 mRNA17997037
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GCNT2 mRNA25729387
D010126OzoneOzone results in increased expression of GCNT2 mRNA19555225
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of GCNT2 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GCNT2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GCNT2 mRNA19429403
D010634PhenobarbitalPhenobarbital affects the expression of GCNT2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of GCNT2 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of GCNT2 mRNA17426115|1844570
D010936Plant ExtractsPlant Extracts results in increased expression of GCNT2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GCNT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GCNT2 mRNA22079256|2271453
D017035PravastatinPravastatin results in increased expression of GCNT2 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of GCNT2 mRNA27225895
D011794QuercetinQuercetin results in decreased expression of GCNT2 mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of GCNT2 mRNA15612046
D012834SilverSilver results in increased expression of GCNT2 mRNA26014281
D012906SmokeSmoke results in increased expression of GCNT2 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of GCNT2 mRNA18812580
D012999SomanSoman results in increased expression of GCNT2 mRNA19281266
C075117squalestatin 1squalestatin 1 affects the expression of GCNT2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of GCNT2 mRNA27225895
D013311StreptozocinStreptozocin results in increased expression of GCNT2 mRNA25905778
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of GCNT2 mRNA"26680231
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GCNT2 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GCNT2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GCNT2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GCNT2 mRNA15800033
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GCNT2 mRNA21215274
D013792ThalidomideThalidomide results in decreased expression of GCNT2 mRNA26217789
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GCNT2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of GCNT2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of GCNT2 mRNA16604517
D014635Valproic AcidValproic Acid affects the expression of GCNT2 mRNA25979313
C034028vanadyl sulfatevanadyl sulfate results in increased expression of GCNT2 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GCNT2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GCNT2 mRNA"27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of GCNT2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008109N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity-IMP12424189  
GO ID GO Term Qualifier Evidence PubMed
GO:0006024glycosaminoglycan biosynthetic process-TAS8449405  
GO:0006486protein glycosylation-IEA-  
GO:0006486protein glycosylation-IMP12424189  
GO:0007179transforming growth factor beta receptor signaling pathway-IMP21750175  
GO:0007275multicellular organism development-TAS9134435  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0010608posttranscriptional regulation of gene expression-IMP21750175  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP21750175  
GO:0010812negative regulation of cell-substrate adhesion-IMP21750175  
GO:0030335positive regulation of cell migration-IMP21750175  
GO:0034116positive regulation of heterotypic cell-cell adhesion-IMP21750175  
GO:0036438maintenance of lens transparency-IMP12424189  
GO:0051897positive regulation of protein kinase B signaling-IMP21750175  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP21750175  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005575cellular_component-ND-  
GO:0005794Golgi apparatus-IDA-  
GO:0016020membrane-TAS8449405  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal