Gene info: ID 26523

Gene: AGO1

GENE ID: 26523

Synonyms: EIF2C|EIF2C1|GERP95|Q99|hAgo1

Description: argonaute 1, RISC catalytic component

Gene type: protein-coding

Location: 1p34.3

dbXrefs: Ensembl:ENSG00000092847 MIM:606228 Vega:OTTHUMG00000007381 UniprotKB:Q9UL18

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.493e-1 (AD) 8.248e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YLPM1	0.875
CDC42BPA	0.873
ZNF445	0.868
HUWE1	0.865
BPTF	0.857
EXOC6B	0.856
GIGYF2	0.855
ZC3H13	0.855
MCM3AP	0.852
RABGAP1	0.85

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.637
OR4F5	-0.606
PRRX2	-0.308
GSC	-0.301
RPE65	-0.299
ASIP	-0.292
S100A3	-0.277
ZNF114	-0.271
HCRT	-0.27
LHX5	-0.268

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AGO1 mRNA"	19114083
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of AGO1 mRNA"	18648102
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of AGO1 gene	27153756
D000393	Air Pollutants	AGO1 gene SNP affects the susceptibility to Air Pollutants	26724585
D001554	Benzene	Benzene results in increased expression of AGO1 mRNA	19162166
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AGO1 mRNA	22300585
D004958	Estradiol	Estradiol affects the expression of AGO1 mRNA	22574217
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of AGO1 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of AGO1 mRNA	26496021
D002220	Carbamazepine	Carbamazepine affects the expression of AGO1 mRNA	25979313
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AGO1 mRNA	24763279
C084597	chlorcyclizine	chlorcyclizine results in decreased expression of AGO1 mRNA	21058326
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AGO1 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AGO1 gene	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of AGO1 mRNA	19320972
D016572	Cyclosporine	Cyclosporine results in decreased expression of AGO1 mRNA	20106945
D013759	Dronabinol	Dronabinol results in increased expression of AGO1 mRNA	16597638
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of AGO1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of AGO1 mRNA	27594783
C000944	dicrotophos	dicrotophos results in increased expression of AGO1 mRNA	28302478
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of AGO1 mRNA	29097150
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AGO1 mRNA	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AGO1 gene	20938992
D005839	Gentamicins	Gentamicins results in increased expression of AGO1 mRNA	22061828
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AGO1 mRNA	24763279
C492448	ICG 001	ICG 001 results in increased expression of AGO1 mRNA	26191083
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of AGO1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of AGO1 mRNA	24796395
D007854	Lead	Lead affects the expression of AGO1 mRNA	28903495
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AGO1 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AGO1 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of AGO1 mRNA	28001369
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of AGO1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of AGO1 mRNA"	25554681
C016030	pantogab	pantogab results in decreased expression of AGO1 mRNA	17379144
D010433	Pentylenetetrazole	Pentylenetetrazole affects the expression of AGO1 mRNA	21503142
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of AGO1 mRNA	22698814
C017947	sodium arsenite	sodium arsenite results in decreased expression of AGO1 mRNA	16014739
D053260	Soot	AGO1 gene SNP affects the susceptibility to Soot	26724585
D013849	Thimerosal	Thimerosal results in decreased expression of AGO1 mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in increased expression of AGO1 mRNA	23557971
D014212	Tretinoin	Tretinoin results in increased expression of AGO1 mRNA	16140955
C057693	troglitazone	troglitazone results in decreased expression of AGO1 mRNA	28973697
D014520	Urethane	Urethane results in increased expression of AGO1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of AGO1 mRNA	26272509
D001335	Vehicle Emissions	AGO1 gene SNP affects the susceptibility to Vehicle Emissions	26724585
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of AGO1 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of AGO1 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of AGO1 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000993	RNA polymerase II core binding	-	IDA	25336585
GO:0001047	core promoter binding	-	IMP	25336585
GO:0003723	RNA binding	-	HDA	22681889
GO:0003723	RNA binding	-	IDA	23809764
GO:0003725	double-stranded RNA binding	-	IDA	19966796
GO:0003727	single-stranded RNA binding	-	IDA	19966796
GO:0004521	endoribonuclease activity	NOT	IDA	23809764
GO:0005515	protein binding	-	IPI	12526743 16289642 16756390 17891150 17932509 18482256 19167051 19324964 19383768 19716330 20616046 22484317 22915799 25036637 25336585 28330616
GO:0035198	miRNA binding	-	IDA	15260970

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000956	nuclear-transcribed mRNA catabolic process	-	IDA	18771919
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	-
GO:0010501	RNA secondary structure unwinding	-	IDA	19966796
GO:0010501	RNA secondary structure unwinding	-	IMP	22795694
GO:0010586	miRNA metabolic process	-	IEA	-
GO:0016525	negative regulation of angiogenesis	-	IMP	23426184
GO:0031054	pre-miRNA processing	-	IDA	19966796
GO:0035194	posttranscriptional gene silencing by RNA	-	TAS	-
GO:0035196	production of miRNAs involved in gene silencing by miRNA	-	IMP	22795694
GO:0035278	miRNA mediated inhibition of translation	-	IDA	18771919
GO:0035279	mRNA cleavage involved in gene silencing by miRNA	NOT	IDA	15260970
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	-	IDA	19966796
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	25336585
GO:0060964	regulation of gene silencing by miRNA	-	TAS	-
GO:0090625	mRNA cleavage involved in gene silencing by siRNA	NOT	IDA	15260970
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000932	P-body	-	IEA	-
GO:0005634	nucleus	-	IC	25336585
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	15260970 20014101
GO:0005829	cytosol	-	TAS	-
GO:0005844	polysome	-	IDA	17932509
GO:0016442	RISC complex	-	IDA	15260970 19966796
GO:0035068	micro-ribonucleoprotein complex	-	IDA	17932509
GO:0070578	RISC-loading complex	-	IDA	19966796
GO:1990904	ribonucleoprotein complex	-	IDA	17932509

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-157118	Signaling by NOTCH	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1912408	Pre-NOTCH Transcription and Translation	TAS
R-HSA-1912422	Pre-NOTCH Expression and Processing	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-203927	MicroRNA (miRNA) biogenesis	TAS
R-HSA-211000	Gene Silencing by RNA	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2559580	Oxidative Stress Induced Senescence	TAS
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2559585	Oncogene Induced Senescence	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	TAS
R-HSA-426496	Post-transcriptional silencing by small RNAs	TAS
R-HSA-5578749	Transcriptional regulation by small RNAs	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	TAS
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8943723	Regulation of PTEN mRNA translation	TAS
R-HSA-8948700	Competing endogenous RNAs (ceRNAs) regulate PTEN translation	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25495208	Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. (2015 Mar)	Gedik H	DNA Cell Biol