Gene: LATS2

26524
KPM
large tumor suppressor kinase 2
protein-coding
13q12.11
Ensembl:ENSG00000150457 MIM:604861 Vega:OTTHUMG00000016531 UniprotKB:Q9NRM7
NC_000013.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.287e-1 (AD)  7.399e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06264663chr13:21563415LATS23.300e-10Smoking27651444
cg00666749chr13:21637118LATS21.160e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAP230.866
MSN0.861
WWTR10.846
NEDD40.841
ZNF2170.841
ELF10.838
CNN20.834
RREB10.831
ANO60.831
DRAM10.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.645
MARCH4-0.631
DLK2-0.63
SMIM18-0.62
ABCC12-0.615
KCNB2-0.614
HAS1-0.605
MYADML2-0.602
LRTM2-0.6
CALHM1-0.598

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of LATS2 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LATS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LATS2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LATS2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LATS2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of LATS2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of LATS2 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of LATS2 mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to LATS2 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LATS2 mRNA"19150397|2001819
D004958EstradiolEstradiol results in decreased expression of LATS2 mRNA24758408
C006780bisphenol Abisphenol A affects the expression of LATS2 mRNA20170705
C006780bisphenol Abisphenol A affects the expression of LATS2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LATS2 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of LATS2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LATS2 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LATS2 gene20938992
D003300CopperCopper results in decreased expression of LATS2 protein16246896
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of LATS2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of LATS2 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of LATS2 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of LATS2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of LATS2 mRNA19770486
C014347decitabinedecitabine affects the methylation of LATS2 promoter17049657
C014347decitabine[decitabine affects the methylation of LATS2 promoter] which affects the expression of LATS2 mRNA17049657|1704965
D003976DiazinonDiazinon affects the expression of LATS2 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LATS2 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LATS2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LATS2 mRNA27392435
D004237DiuronDiuron results in decreased expression of LATS2 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of LATS2 mRNA"23811387
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LATS2 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LATS2 mRNA23649840
C540355fenamidonefenamidone results in increased expression of LATS2 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LATS2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of LATS2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of LATS2 mRNA19167457
D017313FenretinideFenretinide results in decreased expression of LATS2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LATS2 mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LATS2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LATS2 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LATS2 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of LATS2 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LATS2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LATS2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LATS2 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of LATS2 mRNA23811387
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA"18778698
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA]"18778698
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of LATS2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LATS2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LATS2 mRNA25729387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of LATS2 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of LATS2 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of LATS2 mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of LATS2 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LATS2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of LATS2 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of LATS2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LATS2 mRNA27029645
D012834SilverSilver results in increased expression of LATS2 mRNA26014281
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of LATS2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LATS2 mRNA21570461
D013792ThalidomideThalidomide analog results in increased expression of LATS2 mRNA20525221
C009495titanium dioxidetitanium dioxide results in decreased expression of LATS2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LATS2 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LATS2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of LATS2 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LATS2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LATS2 mRNA26272509
C057693troglitazonetroglitazone results in increased expression of LATS2 mRNA28973697
D014520UrethaneUrethane results in increased expression of LATS2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LATS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LATS2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LATS2 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of LATS2 mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of LATS2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA10871863  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI16413547  18158288  19739119  20303269  24255178  24682284  
25026211  25438054  27107012  
GO:0005524ATP binding-IDA10871863  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IBA21873635  
GO:0000082G1/S transition of mitotic cell cycle-IDA12853976  
GO:0006468protein phosphorylation-IDA10871863  
GO:0009755hormone-mediated signaling pathway-IDA15131260  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0035329hippo signaling-IBA21873635  
GO:0035329hippo signaling-IDA20412773  
GO:0035329hippo signaling-TAS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IDA10871863  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IDA12853976  
GO:0046620regulation of organ growth-IBA21873635  
GO:0051301cell division-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP20412773  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IBA21873635  
GO:0000922spindle pole-IDA12853976  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10673337  
GO:0005634nucleus-NAS10673337  
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2028269Signaling by HippoTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24976335Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas. (2014 Aug)Luo SYLung Cancer
22966299Hypermethylation of the large tumor suppressor genes in Japanese lung cancer. (2010 Mar)Sasaki HOncol Lett