Gene: SRPK3

26576
MSSK-1|MSSK1|STK23
SRSF protein kinase 3
protein-coding
Xq28
Ensembl:ENSG00000184343 MIM:301002 Vega:OTTHUMG00000024207 UniprotKB:Q9UPE1
NG_016329.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC1590.773
COL16A10.761
TRPV10.757
HSD17B30.74
UAP1L10.735
PCBP40.731
TJAP10.73
SFSWAP0.727
ABCA20.722
HIP1R0.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.342
OR4F29-0.314
FER1L6-0.299
ASB9-0.286
ARHGEF38-0.274
MTRNR2L9-0.272
ELF5-0.265
FMO1-0.261
IBSP-0.259
TTLL10-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SRPK3 mRNA"18648102
D000393Air PollutantsAir Pollutants results in decreased expression of SRPK3 mRNA25056781
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SRPK3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SRPK3 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SRPK3 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRPK3 mRNA21569818
C006780bisphenol Abisphenol A results in increased expression of SRPK3 mRNA28196854
C006780bisphenol Abisphenol A results in decreased expression of SRPK3 mRNA27178563
C006780bisphenol Abisphenol A results in increased expression of SRPK3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRPK3 mRNA21297351
D002737ChloropreneChloroprene results in decreased expression of SRPK3 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SRPK3 mRNA27858113
D003471CuprizoneCuprizone results in decreased expression of SRPK3 mRNA26577399
D002945CisplatinCisplatin results in increased expression of SRPK3 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of SRPK3 mRNA26033743
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SRPK3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SRPK3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRPK3 mRNA17942748
C082360fipronilfipronil results in increased expression of SRPK3 mRNA23962444
C039281furanfuran results in increased expression of SRPK3 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of SRPK3 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SRPK3 mRNA17183730
D008628MercuryMercury analog results in decreased expression of SRPK3 mRNA25056781
D008694MethamphetamineMethamphetamine results in increased expression of SRPK3 mRNA26307267
D013629TamoxifenTamoxifen affects the expression of SRPK3 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SRPK3 mRNA25172293
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRPK3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SRPK3 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of SRPK3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SRPK3 mRNA20133372
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SRPK3 mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of SRPK3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SRPK3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005515protein binding-IPI23602568  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000245spliceosomal complex assembly-IBA21873635  
GO:0006468protein phosphorylation-IEA-  
GO:0007519skeletal muscle tissue development-IEA-  
GO:0010468regulation of gene expression-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0050684regulation of mRNA processing-IBA21873635  
GO:0060537muscle tissue development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28747766DNA methylation signatures of chronic alcohol dependence in purified CD3(+) T-cells of patients undergoing alcohol treatment. (2017 Jul 26)Bruckmann CSci Rep