Gene: PCOLCE2

26577
PCPE2
procollagen C-endopeptidase enhancer 2
protein-coding
3q23
Ensembl:ENSG00000163710 MIM:607064 Vega:OTTHUMG00000159312 UniprotKB:Q9UKZ9
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
2.047e-1 (AD)  4.443e-1 (ND)   (Frontal_Cortex)
4.670e-1 (AD)  7.221e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9841007chr3:142822845 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS20.741
STK32B0.686
MEGF110.646
KCNG40.613
GALR10.61
LHFPL30.61
BLM0.606
BMP20.604
GNG80.601
CD8B0.6

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNLDC1-0.399
NOS2-0.379
CUX2-0.368
GRB14-0.361
DBH-0.361
ADPRHL1-0.353
CCNO-0.347
RORB-0.345
DAPK1-0.344
KCNQ4-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PCOLCE2 mRNA"23146750
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PCOLCE2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCOLCE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCOLCE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PCOLCE2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PCOLCE2 mRNA27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of PCOLCE2 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of PCOLCE2 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of PCOLCE2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCOLCE2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCOLCE2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PCOLCE2 mRNA22228805|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCOLCE2 mRNA22300585
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of PCOLCE2 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCOLCE2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of PCOLCE2 mRNA19619570|2475840
D004958EstradiolEstradiol results in decreased expression of PCOLCE2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PCOLCE2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PCOLCE2 mRNA15336504
C584509C646 compoundC646 compound results in increased expression of PCOLCE2 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PCOLCE2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PCOLCE2 mRNA27339419
D002922CiguatoxinsCiguatoxins affects the expression of PCOLCE2 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of PCOLCE2 mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased expression of PCOLCE2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of PCOLCE2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PCOLCE2 mRNA25562108
D004041Dietary FatsDietary Fats results in decreased expression of PCOLCE2 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PCOLCE2 mRNA24535843
D004237DiuronDiuron results in decreased expression of PCOLCE2 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCOLCE2 mRNA17942748
D005472FluorouracilPCOLCE2 protein affects the susceptibility to Fluorouracil16217747
D005492Folic AcidFolic Acid affects the expression of PCOLCE2 mRNA17320366
C039281furanfuran results in increased expression of PCOLCE2 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of PCOLCE2 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of PCOLCE2 mRNA26191083
D008694MethamphetaminePCOLCE2 gene SNP affects the susceptibility to Methamphetamine18316681
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to PCOLCE2 promoter]20348232
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PCOLCE2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PCOLCE2 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of PCOLCE2 mRNA16100012
D000073878Palm OilPalm Oil results in decreased expression of PCOLCE2 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PCOLCE2 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCOLCE2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PCOLCE2 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PCOLCE2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of PCOLCE2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of PCOLCE2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PCOLCE2 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of PCOLCE2 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of PCOLCE2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in increased expression of PCOLCE2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PCOLCE2 mRNA23221170
D012906SmokeSmoke results in increased expression of PCOLCE2 mRNA21095227
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCOLCE2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCOLCE2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PCOLCE2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCOLCE2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCOLCE2 mRNA19770486
D019284ThapsigarginThapsigargin results in decreased expression of PCOLCE2 protein24648495
C009495titanium dioxidetitanium dioxide results in decreased expression of PCOLCE2 mRNA19464567|2355797
D014212TretinoinTretinoin results in decreased expression of PCOLCE2 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PCOLCE2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of PCOLCE2 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of PCOLCE2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PCOLCE2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCOLCE2 mRNA24935251|2915479
D014635Valproic AcidValproic Acid results in decreased expression of PCOLCE2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PCOLCE2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PCOLCE2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PCOLCE2 mRNA26272509
C088658zoledronic acidzoledronic acid results in decreased expression of PCOLCE2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005518collagen binding-IDA12393877  
GO:0008201heparin binding-IDA12393877  
GO:0016504peptidase activator activity-IDA12393877  
GO ID GO Term Qualifier Evidence PubMed
GO:0010952positive regulation of peptidase activity-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal