Gene: GREM1

26585
C15DUPq|CKTSF1B1|CRAC1|CRCS4|DAND2|DRM|DUP15q|GREMLIN|HMPS|HMPS1|IHG-2|MPSH|PIG2
gremlin 1, DAN family BMP antagonist
protein-coding
15q13.3
Ensembl:ENSG00000166923 MIM:603054 Vega:OTTHUMG00000129319 UniprotKB:O60565
NG_033791.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.505e-1 (AD)  7.475e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST180.87
FOLH10.868
FRMD4B0.847
MOG0.845
ASPA0.844
C21orf910.841
HHIP0.837
SLC44A10.836
GJB10.835
RASGRP30.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.476
GRB14-0.435
LTK-0.431
CHRNA2-0.411
NEUROD1-0.406
ASGR2-0.383
CALB2-0.378
SHISA8-0.375
WTIP-0.366
SDK1-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of GREM1 mRNA19041380
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in decreased expression of GREM1 mRNA]25827057
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in decreased expression of GREM1 mRNA25827057
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GREM1 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]"17975199
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GREM1 mRNA]"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GREM1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GREM1 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of GREM1 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]"17975199
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of GREM1 mRNA]"17975199
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of GREM1 mRNA"17975199
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GREM1 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of GREM1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GREM1 mRNA16483693
C000228aristolochic acid Iaristolochic acid I results in increased expression of GREM1 mRNA22525892
C000228aristolochic acid Iaristolochic acid I results in increased expression of GREM1 protein22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased activity of BMP7 protein]22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of CDH1 protein]22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD1 protein modified form]22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD5 protein modified form]22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD9 protein modified form]22525892
C000228aristolochic acid IGREM1 mutant form inhibits the reaction [aristolochic acid I results in increased expression of ACTA2 protein]22525892
C000228aristolochic acid IGREM1 protein inhibits the reaction [BMP7 protein results in decreased susceptibility to aristolochic acid I]22525892
C006632arsenic trioxidearsenic trioxide results in decreased expression of GREM1 mRNA19128835
C015001arsenitearsenite results in increased methylation of GREM1 promoter23974009
D017638Asbestos, Crocidolite"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]"17975199
D017638Asbestos, Crocidolite"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]"17975199
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GREM1 mRNA"17975199|1868714
D017638Asbestos, Crocidolite"U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]"17975199
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the localization of GREM1 protein"17975199
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GREM1 mRNA"17975199
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GREM1 protein"17975199
C487081belinostatbelinostat results in increased expression of GREM1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GREM1 mRNA22178795
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GREM1 mRNA21839799
D004958EstradiolEstradiol affects the expression of GREM1 mRNA22574217
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of GREM1 mRNA17404688
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of GREM1 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of GREM1 mRNA25912373
C006780bisphenol Abisphenol A results in decreased methylation of GREM1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of GREM1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GREM1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of GREM1 mRNA26079696
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in decreased expression of GREM1 mRNA]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GREM1 mRNA25827057
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of GREM1 mRNA26272509
D003300CopperCopper deficiency results in increased expression of GREM1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of GREM1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of GREM1 mRNA15755911
D003471CuprizoneCuprizone results in decreased expression of GREM1 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]18200517
C014347decitabinedecitabine results in increased expression of GREM1 mRNA16367923
D003907DexamethasoneDexamethasone inhibits the reaction [BMP2 protein results in increased expression of GREM1 mRNA]15268896
D003907DexamethasoneDexamethasone inhibits the reaction [BMP4 protein results in increased expression of GREM1 mRNA]15268896
D003907DexamethasoneDexamethasone inhibits the reaction [BMP6 protein results in increased expression of GREM1 mRNA]15268896
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GREM1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of GREM1 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GREM1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GREM1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of GREM1 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of GREM1 mRNA16002434|2648566
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of GREM1 mRNA20146380
C118739entinostatentinostat results in increased expression of GREM1 mRNA26272509
C069837fullerene C60fullerene C60 results in decreased expression of GREM1 mRNA19167457
C039281furanfuran results in increased expression of GREM1 mRNA27387713
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of GREM1 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of GREM1 mRNA17109745
D005944GlucosamineIL1B inhibits the reaction [Glucosamine results in decreased expression of GREM1 mRNA]17109745
D005947GlucoseGlucose results in increased expression of GREM1 mRNA10026205|1074466
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GREM1 mRNA28628672
C051890irinotecanirinotecan results in increased expression of GREM1 mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of GREM1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GREM1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of GREM1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GREM1 mRNA25307878
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GREM1 mRNA26644586
C008261lead acetatelead acetate results in increased expression of GREM1 mRNA27562236
D015122MercaptopurineMercaptopurine results in increased expression of GREM1 mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of GREM1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GREM1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GREM1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
D009532NickelNickel results in increased expression of GREM1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide affects the expression of GREM1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of GREM1 mRNA22714537
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GREM1 mRNA17616710
C570897NSC668394NSC668394 results in increased expression of GREM1 mRNA27137931
C016340o,p'-DDT"o,p'-DDT results in increased expression of GREM1 mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GREM1 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of GREM1 mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of GREM1 mRNA22178795
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GREM1 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GREM1 mRNA26272509
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of GREM1 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of GREM1 mRNA17404688|2086464
D011374ProgesteroneProgesterone results in decreased expression of GREM1 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of GREM1 mRNA24780913
C010313pseudocumenepseudocumene results in increased expression of GREM1 protein17337753
C043680ptaquilosideptaquiloside results in decreased expression of GREM1 mRNA23274088
C541923sandostatinLARsandostatinLAR results in increased expression of GREM1 mRNA17210224
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GREM1 mRNA23806026|2589566
D012822Silicon DioxideGREM1 protein inhibits the reaction [Silicon Dioxide results in increased expression of COL1A1 mRNA]27428020
D012822Silicon DioxideGREM1 protein inhibits the reaction [Silicon Dioxide results in increased expression of CXCL10 protein]27428020
D012822Silicon DioxideGREM1 protein inhibits the reaction [Silicon Dioxide results in increased expression of TNC mRNA]27428020
D012906SmokeSmoke results in increased expression of GREM1 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of GREM1 gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of GREM1 mRNA27862939
D013311StreptozocinStreptozocin results in increased expression of GREM1 mRNA10744662
C004648testosterone enanthatetestosterone enanthate affects the expression of GREM1 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GREM1 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GREM1 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GREM1 mRNA20067830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GREM1 mRNA18691609|1993321
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GREM1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GREM1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GREM1 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA18200517
C113580U 0126"U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]"17975199
C022884undecaneundecane results in increased expression of GREM1 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GREM1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GREM1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of GREM1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of GREM1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of GREM1 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GREM1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GREM1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of GREM1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI16545136  20660291  27036124  
GO:0016015morphogen activity-ISS9660951  
GO:0030297transmembrane receptor protein tyrosine kinase activator activity-ISS-  
GO:0036122BMP binding-IDA27036124  
GO:0036122BMP binding-ISS9660951  
GO:0042803protein homodimerization activity-IPI27036124  
GO:0043184vascular endothelial growth factor receptor 2 binding-ISS9660951  
GO:0048018receptor ligand activity-ISS9660951  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IDA16545136  
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0002042cell migration involved in sprouting angiogenesis-ISS9660951  
GO:0002092positive regulation of receptor internalization-ISS9660951  
GO:0003257positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation-ISS9660951  
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0007165signal transduction-ISS-  
GO:0007171activation of transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0007267cell-cell signaling-IEA-  
GO:0008284positive regulation of cell proliferation-IDA16545136  
GO:0009954proximal/distal pattern formation-IEA-  
GO:0010717regulation of epithelial to mesenchymal transition-IMP16816361  
GO:0030199collagen fibril organization-IMP15539560  
GO:0030308negative regulation of cell growth-IEA-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030502negative regulation of bone mineralization-IMP15539560  
GO:0030514negative regulation of BMP signaling pathway-IDA15539560  
GO:0030514negative regulation of BMP signaling pathway-IMP16816361  27036124  
GO:0032331negative regulation of chondrocyte differentiation-IMP10556075  
GO:0032872regulation of stress-activated MAPK cascadeNOTISS9660951  
GO:0033689negative regulation of osteoblast proliferation-IMP15539560  
GO:0043066negative regulation of apoptotic process-IMP10556075  
GO:0045668negative regulation of osteoblast differentiation-IMP27036124  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS9660951  
GO:0046851negative regulation of bone remodeling-IMP15539560  
GO:0048263determination of dorsal identity-IMP9660951  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IEA-  
GO:0051893regulation of focal adhesion assembly-IEA-  
GO:0051973positive regulation of telomerase activity-IDA16545136  
GO:0060173limb development-IMP10556075  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IDA15539560  
GO:0060676ureteric bud formation-IEA-  
GO:0061098positive regulation of protein tyrosine kinase activity-IEA-  
GO:0072331signal transduction by p53 class mediatorNOTISS9660951  
GO:0090027negative regulation of monocyte chemotaxis-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA15539560  
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis-IEA-  
GO:0090191negative regulation of branching involved in ureteric bud morphogenesis-IEA-  
GO:0090291negative regulation of osteoclast proliferation-IMP15539560  
GO:1900086positive regulation of peptidyl-tyrosine autophosphorylation-ISS9660951  
GO:1900155negative regulation of bone trabecula formation-IMP15539560  
GO:1900158negative regulation of bone mineralization involved in bone maturation-IMP15539560  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO:2000273positive regulation of signaling receptor activity-ISS-  
GO:2000727positive regulation of cardiac muscle cell differentiation-ISS9660951  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-NAS9660951  
GO:0009986cell surface-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22367214Characterization of gene-environment interactions for colorectal cancer susceptibility loci. (2012 Apr 15)Hutter CMCancer Res