Gene: SEC14L3

266629
TAP2
SEC14 like lipid binding 3
protein-coding
22q12.2
Ensembl:ENSG00000100012 MIM:612824 Vega:OTTHUMG00000151259 UniprotKB:Q9UDX4
NG_027515.1
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.478e-1 (AD)  2.508e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2G30.377
IFNA100.364
PDX10.362
ZNF4670.357
HPSE20.35
PLA2G50.345
PYGM0.332
ARSF0.331
PLA2G30.325
REN0.323

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC27-0.279
WDR53-0.272
SOSTDC1-0.264
FANCL-0.246
ARMC3-0.243
KRBOX4-0.243
NSA2-0.243
MCM2-0.239
SHQ1-0.234
COMMD2-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00163Vitamin ESmall Molecule59-02-9Approved|NutraceuticalTarget
DB14001alpha-Tocopherol succinateSmall Molecule4345-03-3Approved|NutraceuticalTarget
DB14002D-alpha-Tocopherol acetateSmall Molecule58-95-7Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of SEC14L3 mRNA"25710175
D000082AcetaminophenAcetaminophen affects the expression of SEC14L3 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SEC14L3 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SEC14L3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SEC14L3 mRNA16483693
D001152ArsenicalsArsenicals results in decreased expression of SEC14L3 mRNA28625800
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEC14L3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEC14L3 mRNA22228805|2719552
C006780bisphenol Abisphenol A results in decreased expression of SEC14L3 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of SEC14L3 protein25933445
D003976DiazinonDiazinon results in increased methylation of SEC14L3 gene22964155
D017313FenretinideFenretinide results in decreased expression of SEC14L3 mRNA28973697
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SEC14L3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SEC14L3 mRNA"25554681
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of SEC14L3 protein19438287
D052638Particulate MatterParticulate Matter results in increased expression of SEC14L3 protein17520064
D010634PhenobarbitalPhenobarbital results in decreased expression of SEC14L3 protein19952500
D010936Plant ExtractsPlant Extracts results in decreased expression of SEC14L3 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of SEC14L3 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of SEC14L3 mRNA24780913
D011794QuercetinQuercetin affects the expression of SEC14L3 mRNA18178720
C059514resveratrolresveratrol results in increased expression of SEC14L3 mRNA23419489
D053260SootSoot results in decreased expression of SEC14L3 mRNA26551751
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SEC14L3 mRNA28973375
C009495titanium dioxidetitanium dioxide affects the expression of SEC14L3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SEC14L3 protein27818348
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SEC14L3 protein17520064
C025643vinclozolinvinclozolin affects the expression of SEC14L3 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of SEC14L3 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal