Gene: HS6ST3

266722
HS6ST-3
heparan sulfate 6-O-sulfotransferase 3
protein-coding
13q32.1
Ensembl:ENSG00000185352 MIM:609401 Vega:OTTHUMG00000017232 UniprotKB:Q8IZP7
NC_000013.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.906e-1 (AD)  8.703e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7322488chr13:96264380 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH10.921
GRM50.919
GPR260.915
PPM1E0.912
RGS7BP0.901
CDKL50.898
FAM78B0.891
PCDHAC20.888
SCN8A0.886
SLC9A70.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.609
AGTRAP-0.552
RAB13-0.547
APOM-0.544
HEY2-0.543
HEBP2-0.543
MEF2B-0.539
MPST-0.524
TGFB3-0.523
COPZ2-0.521

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HS6ST3 mRNA"25614096
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HS6ST3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST3 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of HS6ST3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HS6ST3 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HS6ST3 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HS6ST3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HS6ST3 mRNA21714911
C006780bisphenol Abisphenol A results in decreased expression of HS6ST3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HS6ST3 gene28505145
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HS6ST3 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST3 gene20938992
D003300CopperCopper deficiency results in increased expression of HS6ST3 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of HS6ST3 mRNA26577399
D002945CisplatinCisplatin results in decreased expression of HS6ST3 mRNA21603599
D019422Dietary SucroseDietary Sucrose results in increased expression of HS6ST3 mRNA26033743
C118739entinostatentinostat results in decreased expression of HS6ST3 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HS6ST3 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST3 gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HS6ST3 mRNA24763279
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HS6ST3 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of HS6ST3 mRNA24449571
D009532NickelNickel results in decreased expression of HS6ST3 mRNA25583101
D010100OxygenOxygen deficiency affects the methylation of HS6ST3 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of HS6ST3 mRNA24205000
D011441PropylthiouracilPropylthiouracil results in decreased expression of HS6ST3 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HS6ST3 mRNA21570461
D014212TretinoinTretinoin results in increased expression of HS6ST3 mRNA21934132
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HS6ST3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HS6ST3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of HS6ST3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HS6ST3 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HS6ST3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017095heparan sulfate 6-O-sulfotransferase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0015015heparan sulfate proteoglycan biosynthetic process, enzymatic modification-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal