Gene: NPAS4

266743
Le-PAS|NXF|PASD10|bHLHe79
neuronal PAS domain protein 4
protein-coding
11q13.2
Ensembl:ENSG00000174576 MIM:608554 Vega:OTTHUMG00000167045 UniprotKB:Q8IUM7
NC_000011.10
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.713e-1 (AD)  1.914e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOSB0.834
EGR40.743
EGR10.724
ARC0.717
EGR20.707
NR4A30.697
PPP1R15A0.626
NR4A10.614
JUNB0.61
CYR610.608

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFTN2-0.364
GPR17-0.272
LRTOMT-0.263
BTBD8-0.258
GAB1-0.256
VCAN-0.255
UGT8-0.251
ZFHX4-0.249
MYO10-0.246
ANLN-0.244

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NPAS4 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPAS4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPAS4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPAS4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPAS4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPAS4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPAS4 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of NPAS4 mRNA19194377
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NPAS4 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NPAS4 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of NPAS4 mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in increased expression of NPAS4 mRNA21356183
C014347decitabinedecitabine results in increased expression of NPAS4 mRNA21856257
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of NPAS4 mRNA25242112
C118739entinostatentinostat results in decreased expression of NPAS4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPAS4 mRNA"27188386
C004312glycidolglycidol results in decreased expression of NPAS4 mRNA24915197
C008261lead acetatelead acetate results in decreased expression of NPAS4 mRNA22641619
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of NPAS4 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of NPAS4 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NPAS4 mRNA28001369
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPAS4 mRNA"27188386
D011441PropylthiouracilPropylthiouracil results in increased expression of NPAS4 mRNA24780913
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of NPAS4 mRNA19564919
C009250sevofluranesevoflurane results in increased expression of NPAS4 mRNA26206149
D012834SilverSilver results in decreased expression of NPAS4 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to NPAS4 promoter]19654925
D014635Valproic AcidValproic Acid results in decreased expression of NPAS4 mRNA28001369
C025643vinclozolinvinclozolin results in increased expression of NPAS4 mRNA22615374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA14701734  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA24465693  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA14701734  
GO:0005515protein binding-IPI24465693  
GO:0046982protein heterodimerization activity-IDA24465693  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007612learning-ISS-  
GO:0007614short-term memory-ISS-  
GO:0007616long-term memory-ISS-  
GO:0030154cell differentiation-IEA-  
GO:0032228regulation of synaptic transmission, GABAergic-ISS-  
GO:0035176social behavior-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA14701734  24465693  
GO:0048167regulation of synaptic plasticity-ISS-  
GO:0060079excitatory postsynaptic potential-ISS-  
GO:0060080inhibitory postsynaptic potential-ISS-  
GO:0071386cellular response to corticosterone stimulus-IEA-  
GO:1904862inhibitory synapse assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005667transcription factor complex-IEA-  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29093669Cocaine and Caffeine Effects on the Conditioned Place Preference Test: Concomitant Changes on Early Genes within the Mouse Prefrontal Cortex and Nucleus Accumbens. (2017)Muniz JAFront Behav Neurosci
29496477Activation of immediate early genes by nicotine after chronic neonatal nicotine exposure in brain areas involved in stress and anxiety responses. (2018 May 15)Halawa AABrain Res