Gene: GDNF

2668
ATF|ATF1|ATF2|HFB1-GDNF|HSCR3
glial cell derived neurotrophic factor
protein-coding
5p13.2
Ensembl:ENSG00000168621 MIM:600837 Vega:OTTHUMG00000090809 UniprotKB:P39905
NG_011675.2
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.857e-1 (AD)  6.555e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM83G0.783
TNFRSF12A0.77
NGFR0.769
DMBX10.764
BMP20.756
LIF0.738
SPOCD10.737
TMPRSS130.734
RDH100.734
KIAA00400.732

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNA2-0.491
KCNQ4-0.478
SCRT1-0.478
DBH-0.466
AMER3-0.464
FGF9-0.461
IGLON5-0.46
CDH22-0.456
CUX2-0.45
ST6GALNAC5-0.448

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09301Chondroitin sulfateSmall Molecule24967-93-9Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]"27796870
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GDNF mRNA28329830
C1065923,9-bis((ethylthio)methyl)-K-252a"3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]"19647008
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDNF mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]"27796870
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDNF mRNA"27188386
C0408109-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2"9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA"22982731
C0408109-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2"Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]"22982731
C0408109-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2"NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]"22982731
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GDNF protein]26138014
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GDNF mRNA22129741
D000242Cyclic AMP"3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]"19647008
D000242Cyclic AMP"[GDNF protein co-treated with Cyclic AMP] results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"19647008
D000242Cyclic AMP[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium19647008
D000242Cyclic AMPMazindol inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]19647008
D000242Cyclic AMPvanoxerine inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]19647008
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GDNF mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GDNF mRNA23630614
D018350alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidGDNF protein results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid15893467
C067527aluminum maltolateGDNF protein inhibits the reaction [aluminum maltolate affects the localization of BAX protein]11592846
C067527aluminum maltolateGDNF protein inhibits the reaction [aluminum maltolate results in decreased expression of BCL2 protein]11592846
C067527aluminum maltolateGDNF protein inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]11592846
C067527aluminum maltolateGDNF protein promotes the reaction [aluminum maltolate results in increased expression of BCL2L1 protein]11592846
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GDNF mRNA16483693
D003913DextroamphetamineGDNF protein affects the susceptibility to Dextroamphetamine12213621
D003913DextroamphetamineGDNF protein affects the susceptibility to Dextroamphetamine12429192
D003913DextroamphetamineGDNF protein affects the susceptibility to [Dextroamphetamine co-treated with Oxidopamine]11771942
D003913DextroamphetamineGDNF protein affects the susceptibility to [Oxidopamine co-treated with Dextroamphetamine]11312561
D000661AmphetamineGDNF protein affects the susceptibility to Amphetamine16943855
D000661AmphetamineGDNF protein affects the susceptibility to Amphetamine15269253
D000661AmphetamineGDNF protein affects the susceptibility to [Oxidopamine co-treated with Amphetamine]11031079
D000661AmphetamineGDNF protein inhibits the reaction [Oxidopamine inhibits the reaction [Amphetamine results in increased expression of FOS protein]]11031079
D047310ApigeninApigenin inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA]28389404
D001058ApomorphineGDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine]11771942
D001151ArsenicArsenic results in decreased expression of GDNF mRNA19654921
C006632arsenic trioxidearsenic trioxide results in increased expression of GDNF mRNA20458559
C015001arsenitearsenite results in increased methylation of GDNF promoter23974009
C015001arseniteGDNF protein inhibits the reaction [arsenite results in increased activity of CASP12 protein]18226606
C015001arseniteGDNF protein inhibits the reaction [arsenite results in increased activity of CASP3 protein]18226606
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GDNF mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GDNF mRNA22316170
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GDNF mRNA"20382639
D004958EstradiolEstradiol results in increased expression of and results in increased secretion of GDNF protein15893467
D004958EstradiolEstradiol results in increased expression of GDNF mRNA15893467
C006780bisphenol Abisphenol A results in decreased methylation of GDNF promoter27271280
C006780bisphenol Abisphenol A results in decreased expression of GDNF mRNA17515113
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GDNF promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of GDNF mRNA25181051|2614162
C006780bisphenol Abisphenol A results in increased expression of GDNF mRNA26186136
D001971BromocriptineBromocriptine results in decreased expression of GDNF mRNA12770616
D001971BromocriptineBromocriptine results in decreased secretion of GDNF protein12770616
D002066BusulfanBusulfan affects the expression of GDNF mRNA20684317
D002066BusulfanBusulfan results in increased expression of GDNF mRNA22082982|2652424
C018475butyraldehydebutyraldehyde results in increased expression of GDNF mRNA26079696
C047047cabergolinecabergoline results in increased expression of GDNF mRNA12770616
C047047cabergolinecabergoline results in increased secretion of GDNF protein12770616
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GDNF protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GDNF protein26138014
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GDNF mRNA20360939
D002330CarmustineGDNF protein results in decreased susceptibility to Carmustine19138852
D002737ChloropreneChloroprene results in decreased expression of GDNF mRNA23125180
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein15385557
C043561chrysinchrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein]29054324
D003042CocaineCocaine results in decreased expression of GDNF mRNA14622243
D003520CyclophosphamideCyclophosphamide results in increased expression of GDNF mRNA10683293
D003609Dactinomycin"Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]"22982731
D003609DactinomycinDactinomycin inhibits the reaction [NEPP11 compound results in increased expression of GDNF mRNA]22982731
D003609DactinomycinDactinomycin results in decreased expression of GDNF mRNA22982731
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein15385557
D003907DexamethasoneDexamethasone results in decreased expression of GDNF mRNA22733784
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GDNF promoter23359474
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D002945CisplatinCisplatin results in increased expression of GDNF24704392
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GDNF promoter23359474
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GDNF mRNA22677342
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GDNF mRNA20360939
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GDNF mRNA22129741
D004298DopamineGDNF protein inhibits the reaction [Oxidopamine results in decreased secretion of Dopamine]12213621
D004298DopamineGDNF protein results in increased metabolism of Dopamine15269253
C060297echinacosideechinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF]27432061
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D000431EthanolEthanol affects the expression of GDNF mRNA22198099
D000431EthanolEthanol results in decreased expression of GDNF protein19397965
D000431Ethanol[Ethanol co-treated with resveratrol] results in increased expression of GDNF mRNA23770283
D000431EthanolEthanol results in increased expression of GDNF protein23770283
D000431Ethanolresveratrol promotes the reaction [Ethanol results in increased expression of GDNF protein]23770283
C020748ferrous sulfateGDNF protein results in decreased susceptibility to ferrous sulfate17935603
D005411Flame RetardantsFlame Retardants results in increased expression of GDNF mRNA27219277
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GDNF mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of GDNF mRNA28329830
D005473FluoxetineFluoxetine results in increased expression of GDNF mRNA15456934
D005473FluoxetineU 0126 inhibits the reaction [Fluoxetine results in increased expression of GDNF mRNA]15456934
C039281furanfuran results in decreased expression of GDNF mRNA25539665|2619464
D006025GlycosaminoglycansGlycosaminoglycans affects the reaction [GDNF protein promotes the reaction [GFRA1 protein results in increased activity of RET protein]]20807638
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of GDNF mRNA27219277
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of GDNF mRNA17997286
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of GDNF mRNA]17997286
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GDNF mRNA22129741
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GDNF mRNA24503145
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GDNF protein24503145
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GDNF mRNA28693884
D008094Lithium[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein12914250
C025340manganese chloridemanganese chloride results in increased methylation of GDNF gene27913844
D008454MazindolMazindol inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]19647008
D008694MethamphetamineGDNF protein results in decreased susceptibility to Methamphetamine17356005
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GDNF mRNA21385734
D008774MethylphenidateMethylphenidate results in decreased expression of GDNF mRNA22470460
D0156551-Methyl-4-phenylpyridinium"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]"27796870
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GDNF27432061
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein27796870
D0156551-Methyl-4-phenylpyridinium"3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]"19647008
D0156551-Methyl-4-phenylpyridinium"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]"27796870
D0156551-Methyl-4-phenylpyridiniumechinacoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF]27432061
D0156551-Methyl-4-phenylpyridinium[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium19647008
D0156551-Methyl-4-phenylpyridiniumMazindol inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]19647008
D0156551-Methyl-4-phenylpyridiniumpuerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]27796870
D0156551-Methyl-4-phenylpyridiniumvanoxerine inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]19647008
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GDNF mRNA28268219
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein28268219
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[GDNF protein co-treated with Cyclic AMP] results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"19647008
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]"23747572
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein]"23747572
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased expression of FOS mRNA]22564763
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased expression of FOS protein]22564763
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased phosphorylation of MAPK1 protein]22564763
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [GDNF protein results in increased phosphorylation of MAPK3 protein]22564763
C523799MRK 003GDNF results in increased susceptibility to MRK 00319903844
C568376MT19c compoundMT19c compound results in decreased expression of GDNF mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of GDNF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GDNF mRNA"25554681
C424427NEPP11 compoundDactinomycin inhibits the reaction [NEPP11 compound results in increased expression of GDNF mRNA]22982731
C424427NEPP11 compoundNEPP11 compound results in increased expression of GDNF mRNA22982731
C029938nickel sulfatenickel sulfate results in decreased expression of GDNF mRNA22714537
C007350nitrofennitrofen results in decreased expression of GDNF mRNA20152352
C007350nitrofennitrofen results in decreased expression of GDNF protein20152352
C007350nitrofennitrofen results in increased expression of GDNF mRNA20152352
C007350nitrofennitrofen results in increased expression of GDNF protein20152352
D016627OxidopamineGDNF protein affects the susceptibility to Oxidopamine12213621
D016627OxidopamineGDNF protein inhibits the reaction [Oxidopamine results in decreased secretion of Dopamine]12213621
D016627Oxidopaminechrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein]29054324
D016627OxidopamineOxidopamine results in decreased expression of GDNF protein29054324
D016627OxidopamineGDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine]11771942
D016627OxidopamineGDNF protein affects the susceptibility to [Dextroamphetamine co-treated with Oxidopamine]11771942
D016627OxidopamineGDNF protein affects the susceptibility to Oxidopamine11031079|1131256
D016627OxidopamineGDNF protein affects the susceptibility to [Oxidopamine co-treated with Amphetamine]11031079
D016627OxidopamineGDNF protein affects the susceptibility to [Oxidopamine co-treated with Dextroamphetamine]11312561
D016627OxidopamineGDNF protein inhibits the reaction [Oxidopamine inhibits the reaction [Amphetamine results in increased expression of FOS protein]]11031079
D010100OxygenGDNF protein results in decreased susceptibility to Oxygen17935603
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of GDNF mRNA]21688324
D010269ParaquatGDNF protein results in decreased susceptibility to Paraquat17935603
D010269ParaquatParaquat results in increased expression of GDNF mRNA21688324
D010479PergolidePergolide results in increased expression of GDNF mRNA12770616
D010479PergolidePergolide results in increased secretion of GDNF protein12770616
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDNF mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GDNF mRNA26272509
D010862Pilocarpine[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein12914250
D010862PilocarpinePilocarpine results in increased expression of GDNF mRNA7854063
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of GDNF mRNA22714537
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D011374ProgesteroneProgesterone results in increased expression of GDNF mRNA22238285
C033607puerarin"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [puerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]]"27796870
C033607puerarinpuerarin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GDNF protein]27796870
C031967rasagilinerasagiline results in increased expression of GDNF mRNA14687604
C031967rasagilinerasagiline results in increased expression of GDNF protein14687604
C031967rasagilineSulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]14687604
C059514resveratrol[Ethanol co-treated with resveratrol] results in increased expression of GDNF mRNA23770283
C059514resveratrolresveratrol promotes the reaction [Ethanol results in increased expression of GDNF protein]23770283
D012402RotenoneGDNF protein affects the reaction [PITX3 protein results in decreased susceptibility to Rotenone]18646205
D012402RotenoneApigenin inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA]28389404
D012402RotenoneRotenone results in decreased expression of GDNF mRNA28389404
D012402RotenoneGDNF protein results in decreased susceptibility to Rotenone18646205
D012431RutinRutin results in increased expression of GDNF mRNA28693884
C036617salsolinolsalsolinol results in decreased expression of GDNF protein23261589
C076944salvianolic acid BNFE2L2 protein affects the reaction [salvianolic acid B results in increased expression of GDNF mRNA]24991814
C076944salvianolic acid BNFE2L2 protein affects the reaction [salvianolic acid B results in increased secretion of GDNF protein]24991814
C076944salvianolic acid Bsalvianolic acid B results in increased expression of GDNF mRNA24991814
C076944salvianolic acid Bsalvianolic acid B results in increased secretion of GDNF protein24991814
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GDNF mRNA23806026
D012834SilverSilver inhibits the reaction [GDNF protein results in increased activity of FYN protein]20488942
D019821SimvastatinSimvastatin results in increased expression of GDNF20851742
D012906SmokeSmoke results in increased expression of GDNF mRNA23693141
C017947sodium arsenitesodium arsenite results in increased expression of GDNF mRNA16014739
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of GDNF mRNA]17997286
D012460SulfasalazineSulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]14687604
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]"23747572
C084178telmisartan"telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein]"23747572
D013739TestosteroneTestosterone results in increased expression of GDNF mRNA25181385
D013739TestosteroneTestosterone results in increased expression of GDNF protein25181385
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GDNF mRNA17586704
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GDNF mRNA18691609
D013749TetrachlorodibenzodioxinGDNF protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CLDN5 protein]26582458
D013749TetrachlorodibenzodioxinGDNF protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TJP1 protein]26582458
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GDNF mRNA26582458
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased secretion of GDNF protein"12770616
D014050TolueneToluene results in increased expression of GDNF protein10983624
D014212TretinoinTretinoin results in increased secretion of GDNF protein16849523
D014212Tretinoin[Tretinoin results in increased secretion of GDNF protein] which results in increased activity of RET protein16849523
D014212TretinoinTretinoin results in decreased expression of GDNF protein17026715
D014212TretinoinU 0126 inhibits the reaction [Tretinoin results in decreased expression of GDNF protein]17026715
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GDNF gene27618143
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GDNF mRNA29024780
C113580U 0126U 0126 inhibits the reaction [Tretinoin results in decreased expression of GDNF protein]17026715
C113580U 0126U 0126 inhibits the reaction [Fluoxetine results in increased expression of GDNF mRNA]15456934
C043425vanoxerinevanoxerine inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium]19647008
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA25607892
D019287Zinc SulfateZinc Sulfate results in decreased expression of GDNF mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-TAS10829012  
GO:0005515protein binding-IPI25416956  
GO:0008083growth factor activity-IEA-  
GO:0042803protein homodimerization activity-IDA8493557  8988018  
GO:1902379chemoattractant activity involved in axon guidance-TAS22998873  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001656metanephros development-ISS-  
GO:0001658branching involved in ureteric bud morphogenesis-ISS-  
GO:0001755neural crest cell migration-IDA15242795  
GO:0001759organ induction-IEA-  
GO:0001941postsynaptic membrane organization-IEA-  
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis-IEA-  
GO:0007165signal transduction-TAS7830769  
GO:0007399nervous system development-TAS22998873  
GO:0007411axon guidance-TAS-  
GO:0008284positive regulation of cell proliferation-IDA22897442  
GO:0008344adult locomotory behavior-TAS12358785  
GO:0010468regulation of gene expression-IGI22897442  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0021516dorsal spinal cord development-ISS-  
GO:0021784postganglionic parasympathetic fiber development-ISS-  
GO:0030432peristalsis-ISS-  
GO:0031175neuron projection development-IDA15242795  
GO:0031175neuron projection development-TAS22998873  
GO:0032770positive regulation of monooxygenase activity-IDA12358785  
GO:0033603positive regulation of dopamine secretion-TAS12358785  
GO:0043066negative regulation of apoptotic process-TAS7830769  
GO:0043524negative regulation of neuron apoptotic process-IDA8493557  
GO:0045597positive regulation of cell differentiation-IGI22897442  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12358785  
GO:0048255mRNA stabilization-IDA12358785  
GO:0048484enteric nervous system development-ISS-  
GO:0048485sympathetic nervous system development-ISS-  
GO:0048568embryonic organ development-ISS-  
GO:0051584regulation of dopamine uptake involved in synaptic transmission-IDA8493557  
GO:0060676ureteric bud formation-IEA-  
GO:0060688regulation of morphogenesis of a branching structure-ISS-  
GO:0071679commissural neuron axon guidance-ISS-  
GO:0072107positive regulation of ureteric bud formation-IDA8657307  
GO:0072108positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-IEA-  
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis-IDA8657307  17229286  
GO:2000736regulation of stem cell differentiation-TAS23626767  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IDA10921886  
GO:2001260regulation of semaphorin-plexin signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA9811930  
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-8853659RET signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15659598Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. (2005 Jan 19)He DYJ Neurosci
24331739Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress. (2014 May)Viola TWJ Psychiatry Neurosci
27994179Association between smoking behaviour and genetic variants of glial cell line-derived neurotrophic factor. (2016 Dec)Kotyuk EJ Genet
29066725Heparan sulfate: Resilience factor and therapeutic target for cocaine abuse. (2017 Oct 24)Chen JSci Rep
25975578The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. (2015)Lin CCancer Biol Ther
15899247Glial cell line-derived neurotrophic factor-conjugated nanoparticles suppress acquisition of cocaine self-administration in rats. (2005 Jul)Green-Sadan TExp Neurol
25234806Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. (2015 Jan)Dijkstra AEEur Respir J
25155311Ethanol and nicotine interaction within the posterior ventral tegmental area in male and female alcohol-preferring rats: evidence of synergy and differential gene activation in the nucleus accumbens shell. (2015 Feb)Truitt WAPsychopharmacology (Berl)
20482506Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence. (2010)Leggio LCurr Pharm Des
26346883Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. (2016 Aug)Peregud DICell Mol Neurobiol
25251136Rutin upregulates neurotrophic factors resulting in attenuation of ethanol-induced oxidative stress in HT22 hippocampal neuronal cells. (2015 Aug 15)Song KJ Sci Food Agric