Gene info: ID 2669

Gene: GEM

GENE ID: 2669

Synonyms: KIR

Description: GTP binding protein overexpressed in skeletal muscle

Gene type: protein-coding

Location: 8q22.1

dbXrefs: Ensembl:ENSG00000164949 MIM:600164 Vega:OTTHUMG00000164392 UniprotKB:P55040

RefSeq: NC_000008.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.827e-1 (AD) 9.552e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NFKB2	0.827
TGIF1	0.825
PNP	0.797
ZC3H12A	0.795
TIPARP	0.794
MAFF	0.786
ZFP36L1	0.785
BAG3	0.783
CDKN1A	0.781
RNF122	0.778

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDCA5	-0.514
ABCC12	-0.513
SLC7A4	-0.512
KCNB2	-0.509
CALHM1	-0.506
LRRC38	-0.494
AGMAT	-0.489
LHX6	-0.489
PPEF1	-0.487
CNTN6	-0.486

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of GEM mRNA	23792671
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of GEM mRNA"	20406850
C012796	2-butenal	2-butenal results in increased expression of GEM mRNA	20471460
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GEM mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GEM mRNA"	27188386
D000079	Acetaldehyde	Acetaldehyde results in increased expression of GEM mRNA	23416264
D000082	Acetaminophen	Acetaminophen results in increased expression of GEM mRNA	21420995\|2906747
D000082	Acetaminophen	GEM gene polymorphism affects the susceptibility to Acetaminophen	26104854
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GEM protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GEM mRNA	22100608\|2715375
D015766	Albendazole	[Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA	16861626
D000638	Amiodarone	Amiodarone results in increased expression of GEM mRNA	19774075
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of GEM mRNA"	25757056
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of GEM mRNA"	18687144\|2535159
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in increased expression of GEM mRNA	24758408
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of GEM mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GEM mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of GEM mRNA	19619570\|2010694
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of GEM mRNA]	24758408
D004958	Estradiol	Estradiol affects the expression of GEM mRNA	15598610
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of GEM mRNA	18192240
C044887	beta-methylcholine	beta-methylcholine affects the expression of GEM mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GEM mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of GEM mRNA	26364221
C006780	bisphenol A	bisphenol A results in increased expression of GEM mRNA	27685785\|2927551
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GEM mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of GEM mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GEM mRNA	28628672
D020122	tert-Butylhydroperoxide	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA	20847119
D020122	tert-Butylhydroperoxide	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GEM mRNA	20847119
D020122	tert-Butylhydroperoxide	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of GEM mRNA]	20847119
C018475	butyraldehyde	butyraldehyde results in increased expression of GEM mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of GEM mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of GEM mRNA	21694771
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of GEM promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of GEM mRNA	17484886
D002737	Chloroprene	Chloroprene results in decreased expression of GEM mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GEM mRNA	20938992
D003042	Cocaine	Cocaine results in increased expression of GEM mRNA	15009677
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of GEM mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of GEM mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of GEM mRNA	19549813
D003375	Coumestrol	Coumestrol results in increased expression of GEM mRNA	19167446
C030973	cupric oxide	cupric oxide results in increased expression of GEM mRNA	22077320
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of GEM mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in increased expression of GEM mRNA	20106945\|2556210
D003703	Demecolcine	Demecolcine results in increased expression of GEM mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in decreased expression of GEM mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GEM mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GEM mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GEM mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of GEM mRNA	21041162
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GEM mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GEM mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of GEM mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of GEM mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of GEM mRNA	22023808
D002117	Calcitriol	Calcitriol results in increased expression of GEM mRNA	14996990\|1600243
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of GEM mRNA	24690739
C521792	DMU-212	DMU-212 affects the expression of GEM mRNA	26428916
D004317	Doxorubicin	Doxorubicin affects the expression of GEM mRNA	15205334
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA]	18089841
D005472	Fluorouracil	Fluorouracil affects the expression of GEM mRNA	15205334
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of GEM mRNA	24657277
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GEM mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of GEM mRNA	20655997
D005947	Glucose	Glucose results in increased expression of GEM mRNA	17178593
C010178	heliotrine	heliotrine results in increased expression of GEM mRNA	26100227
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GEM mRNA	21179406
C492448	ICG 001	ICG 001 results in decreased expression of GEM mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GEM mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GEM mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GEM mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GEM mRNA	25613284
C051890	irinotecan	irinotecan results in increased expression of GEM mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GEM mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GEM mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GEM mRNA	28628672
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of GEM mRNA	18089841
D007559	Ivermectin	[Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA	16861626
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of GEM mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of GEM mRNA	25307878
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of GEM mRNA	24796395
D007854	Lead	Lead results in decreased expression of GEM mRNA	19921347
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] affects the expression of GEM mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of GEM mRNA	19564919
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GEM mRNA	20938992
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of GEM mRNA	24657277
D008727	Methotrexate	Methotrexate results in decreased expression of GEM mRNA	17400583
D008727	Methotrexate	Methotrexate results in increased expression of GEM mRNA	17379860\|2465727
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GEM mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of GEM mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GEM mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GEM mRNA"	25102311
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GEM mRNA"	25554681
D009532	Nickel	Nickel affects the expression of GEM mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of GEM mRNA]	14575637
D009538	Nicotine	Nicotine results in increased expression of GEM mRNA	17456735
C570896	NSC305787	NSC305787 results in increased expression of GEM mRNA	27137931
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of GEM mRNA	20971185
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of GEM mRNA	24888373
D010126	Ozone	Ozone results in increased expression of GEM mRNA	28623178
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of GEM mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of GEM mRNA	26705709
C046012	pentanal	pentanal results in increased expression of GEM mRNA	26079696
D010634	Phenobarbital	Phenobarbital affects the expression of GEM mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GEM mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of GEM mRNA	26272509
C060836	pioglitazone	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA	20847119
D010938	Plant Oils	Plant Oils results in increased expression of GEM mRNA	23370395
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of GEM mRNA	24888373
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of GEM mRNA	22714537
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of GEM mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of GEM mRNA	22238285
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in increased expression of GEM mRNA	26100227
D011794	Quercetin	Quercetin results in increased expression of GEM mRNA	21632981
C089730	rosiglitazone	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA	20847119
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] affects the expression of GEM mRNA	19564919
C534628	SCH 23390	SCH 23390 results in decreased expression of GEM mRNA	19564919
C009237	senecionine	senecionine results in increased expression of GEM mRNA	26100227
C009238	senkirkine	senkirkine results in increased expression of GEM mRNA	26100227
C078903	seocalcitol	seocalcitol results in increased expression of GEM mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of GEM mRNA	23806026\|2589566
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of GEM mRNA	22300531\|2535159
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of GEM mRNA	19073995\|2322117
D020123	Sirolimus	[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of GEM mRNA	25307878
C009277	sodium arsenate	sodium arsenate results in increased expression of GEM mRNA	21795629
D012999	Soman	Soman results in increased expression of GEM mRNA	19281266
D053260	Soot	Soot results in increased expression of GEM mRNA	26551751
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of GEM mRNA]	24758408
D013629	Tamoxifen	Tamoxifen results in increased expression of GEM mRNA	25123088
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GEM mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GEM mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GEM mRNA	21041162
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of GEM mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GEM mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of GEM mRNA	21694771
C009495	titanium dioxide	titanium dioxide results in increased expression of GEM mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GEM mRNA	28065790
C483909	torcetrapib	torcetrapib results in increased expression of GEM mRNA	19164467\|2322803
C011559	tributyltin	tributyltin results in increased expression of GEM mRNA	21683754
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of GEM mRNA]	14575637
C012589	trichostatin A	trichostatin A results in decreased expression of GEM mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of GEM mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GEM mRNA"	26179874
C057693	troglitazone	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA	20847119
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of GEM mRNA]	20847119
D014520	Urethane	Urethane results in increased expression of GEM mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of GEM mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of GEM mRNA	24935251\|2915479
D014635	Valproic Acid	Valproic Acid affects the expression of GEM mRNA	17292431
D014638	Vanadates	Vanadates results in increased expression of GEM mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GEM gene	25560391
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of GEM mRNA	18593933
C088658	zoledronic acid	zoledronic acid results in decreased expression of GEM mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IDA	17107948
GO:0003924	GTPase activity	-	IDA	17107948
GO:0005246	calcium channel regulator activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	12093360 14701738 16189514 16924111 19060904 20679232 25416956
GO:0005516	calmodulin binding	-	IEA	-
GO:0005525	GTP binding	-	IBA	21873635
GO:0005525	GTP binding	-	IDA	17107948
GO:0019003	GDP binding	-	IDA	17052716 17107948

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000278	mitotic cell cycle	-	IMP	22964304
GO:0006955	immune response	-	TAS	7912851
GO:0007165	signal transduction	-	TAS	7912851 8825643
GO:0007166	cell surface receptor signaling pathway	-	TAS	7912851
GO:0051276	chromosome organization	-	IMP	22964304
GO:0051310	metaphase plate congression	-	IMP	22964304
GO:1901842	negative regulation of high voltage-gated calcium channel activity	-	IEA	-
GO:1903169	regulation of calcium ion transmembrane transport	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0009898	cytoplasmic side of plasma membrane	-	IDA	7912851
GO:0030496	midbody	-	IDA	22964304
GO:0051233	spindle midzone	-	IDA	22964304
GO:0072686	mitotic spindle	-	IDA	22964304

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26323932	Predictors and impact of cytotoxic second-line chemotherapy for stage IIIa-IV nonsmall lung cancer patients in China: A retrospective institution analysis of 132 patients. (2015 Aug)	Cheng B	J Cancer Res Ther
11410715	Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. (2001 Jun)	Xu Y	Alcohol Clin Exp Res
21368495	[A case of lung adenocarcinoma with postoperative recurrence maintaining complete remission by treatment with gefitinib]. (2011 Feb)	Morio A	Gan To Kagaku Ryoho