Gene info: ID 2672

Gene: GFI1

GENE ID: 2672

Synonyms: GFI-1|GFI1A|SCN2|ZNF163

Description: growth factor independent 1 transcriptional repressor

Gene type: protein-coding

Location: 1p22.1

dbXrefs: Ensembl:ENSG00000162676 MIM:600871 Vega:OTTHUMG00000010897 UniprotKB:Q99684

RefSeq: NG_007874.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 13

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.472e-1 (AD) 3.378e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg09935388	chr1:92947588	GFI1		2.310e-84	Maternal smoking in pregnancy	27040690
cg14179389	chr1:92947961	GFI1		6.260e-68	Maternal smoking in pregnancy	27040690
cg12876356	chr1:92946825	GFI1		2.310e-71	Maternal smoking in pregnancy	27040690
cg18146737	chr1:92946700	GFI1		1.790e-63	Maternal smoking in pregnancy	27040690
cg09662411	chr1:92946132	GFI1		6.690e-52	Maternal smoking in pregnancy	27040690
cg18316974	chr1:92947035	GFI1		1.050e-53	Maternal smoking in pregnancy	27040690
cg06338710	chr1:92946187	GFI1		8.790e-41	Maternal smoking in pregnancy	27040690
cg10399789	chr1:92945668	GFI1		2.070e-29	Maternal smoking in pregnancy	27040690
cg04535902	chr1:92947332	GFI1		2.150e-18	Maternal smoking in pregnancy	27040690
cg09935388	chr1:92947588	GFI1		6.610e-111	Maternal smoking in pregnancy	27040690
cg14179389	chr1:92947961	GFI1		2.790e-101	Maternal smoking in pregnancy	27040690
cg12876356	chr1:92946825	GFI1		8.350e-99	Maternal smoking in pregnancy	27040690
cg18146737	chr1:92946700	GFI1		6.140e-91	Maternal smoking in pregnancy	27040690
cg09662411	chr1:92946132	GFI1		6.350e-76	Maternal smoking in pregnancy	27040690
cg18316974	chr1:92947035	GFI1		1.470e-67	Maternal smoking in pregnancy	27040690
cg06338710	chr1:92946187	GFI1		5.560e-49	Maternal smoking in pregnancy	27040690
cg10399789	chr1:92945668	GFI1		1.170e-34	Maternal smoking in pregnancy	27040690
cg04535902	chr1:92947332	GFI1		1.390e-22	Maternal smoking in pregnancy	27040690
cg09935388	chr1:92947588	GFI1		2.290e-119	Maternal smoking in pregnancy	27040690
cg14179389	chr1:92947961	GFI1		2.780e-107	Maternal smoking in pregnancy	27040690
cg12876356	chr1:92946825	GFI1		9.280e-108	Maternal smoking in pregnancy	27040690
cg18146737	chr1:92946700	GFI1		2.580e-100	Maternal smoking in pregnancy	27040690
cg09662411	chr1:92946132	GFI1		4.960e-85	Maternal smoking in pregnancy	27040690
cg18316974	chr1:92947035	GFI1		8.760e-74	Maternal smoking in pregnancy	27040690
cg06338710	chr1:92946187	GFI1		5.540e-56	Maternal smoking in pregnancy	27040690
cg10399789	chr1:92945668	GFI1		1.000e-47	Maternal smoking in pregnancy	27040690
cg04535902	chr1:92947332	GFI1		5.820e-22	Maternal smoking in pregnancy	27040690
cg04955573	chr1:92944306	GFI1		3.210e-14	Maternal smoking in pregnancy	27040690
cg14179389	chr1:92947961	GFI1		5.460e-16	Maternal smoking in pregnancy	27040690
cg09935388	chr1:92947588	GFI1		3.100e-17	Smoking	27651444
cg09662411	chr1:92946132	GFI1		2.200e-16	Smoking	27651444
cg12876356	chr1:92946825	GFI1		1.500e-15	Smoking	27651444
cg18146737	chr1:92946700	GFI1		4.800e-15	Smoking	27651444
cg18316974	chr1:92947035	GFI1		5.200e-14	Smoking	27651444
cg06338710	chr1:92946187	GFI1		1.700e-12	Smoking	27651444
cg14179389	chr1:92947961	GFI1		1.700e-9	Smoking	27651444
cg10399789	chr1:92945668	GFI1		7.100e-9	Smoking	27651444
cg09935388	chr1:92947588	GFI1		2.070e-17	Alcohol consumption per day	27843151
cg12876356	chr1:92946825	GFI1		5.860e-13	Alcohol consumption per day	27843151
cg18146737	chr1:92946700	GFI1		1.530e-9	Alcohol consumption per day	27843151
cg18316974	chr1:92947035	GFI1		1.900e-9	Alcohol consumption per day	27843151
cg09935388	chr1:92947588	GFI1		8.360e-26	Tobacco smoking	28225026
cg12876356	chr1:92946825	GFI1		2.090e-14	Tobacco smoking	28225026
cg18146737	chr1:92946700	GFI1		3.230e-11	Tobacco smoking	28225026
cg18316974	chr1:92947035	GFI1		5.150e-11	Tobacco smoking	28225026
cg09662411	chr1:92946132	GFI1		3.170e-8	Tobacco smoking	28225026
cg09935388	chr1:92947588	GFI1		8.640e-48	Smoking	28686328
cg12876356	chr1:92946825	GFI1		7.500e-35	Smoking	28686328
cg18316974	chr1:92947035	GFI1		1.070e-32	Smoking	28686328
cg09662411	chr1:92946132	GFI1		4.300e-28	Smoking	28686328
cg18146737	chr1:92946700	GFI1		3.100e-26	Smoking	28686328
cg06338710	chr1:92946187	GFI1		1.870e-23	Smoking	28686328
cg04535902	chr1:92947332	GFI1		1.030e-21	Smoking	28686328
cg10399789	chr1:92945668	GFI1		7.990e-19	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FCRL3	0.718
IL2RB	0.695
SLAMF7	0.688
TBX21	0.684
PARP15	0.678
KIR2DS4	0.673
DCAF4L2	0.661
LCK	0.656
PRF1	0.655
OR4D11	0.651

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C1orf53	-0.345
OMG	-0.321
B3GALT1	-0.305
ZNF835	-0.304
FUT9	-0.301
PURG	-0.298
LGI1	-0.294
GGH	-0.286
CRYBA2	-0.285
C19orf73	-0.283

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in increased expression of GFI1 mRNA	26690555
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GFI1 gene	27153756
C430898	AGN 194204	AGN 194204 results in increased expression of GFI1 mRNA	16339527
D000447	Aldehydes	Aldehydes results in increased expression of GFI1 mRNA	25014914
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GFI1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GFI1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of GFI1 gene	25304211
D001280	Atrazine	Atrazine results in increased expression of GFI1 mRNA	25929836
D001554	Benzene	Benzene results in increased expression of GFI1 mRNA	19162166
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of GFI1 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GFI1 mRNA	22316170\|2623829
C006780	bisphenol A	bisphenol A results in decreased expression of GFI1 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of GFI1 mRNA	17553608
C018475	butyraldehyde	butyraldehyde results in increased expression of GFI1 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GFI1 mRNA	24982889
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of GFI1 mRNA	23650126
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFI1 gene	20938992
D003367	Cotinine	Cotinine affects the methylation of GFI1 gene	22851337
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of GFI1 mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in decreased expression of GFI1 mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of GFI1 mRNA	23914054
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of GFI1 mRNA	17330099
D003907	Dexamethasone	Dexamethasone results in decreased expression of GFI1 mRNA	21041162
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of GFI1 mRNA	28962523
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of GFI1 mRNA	21041162
D005038	Ethylnitrosourea	Ethylnitrosourea results in decreased expression of GFI1 protein	28549617
D005419	Flavonoids	Flavonoids results in increased expression of GFI1 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFI1 gene	20938992
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of GFI1 mRNA	25982114
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFI1 gene	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of GFI1 mRNA	17400583
D009532	Nickel	Nickel results in increased expression of GFI1 mRNA	24768652\|2558310
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of GFI1 mRNA	25729387
C046012	pentanal	pentanal results in increased expression of GFI1 mRNA	26079696
C467566	pomalidomide	pomalidomide results in increased expression of GFI1 mRNA	15292067
D011374	Progesterone	Progesterone results in increased expression of GFI1 mRNA	21768398
D011374	Progesterone	TGFB1 protein promotes the reaction [Progesterone results in increased expression of GFI1 mRNA]	21768398
C005556	propionaldehyde	propionaldehyde results in increased expression of GFI1 mRNA	26079696
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of GFI1 mRNA	19073995
D013629	Tamoxifen	Tamoxifen results in increased expression of GFI1 mRNA	19031437
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GFI1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GFI1 mRNA	16102516\|2104116
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of GFI1 mRNA	16888099
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of GFI1 gene	26756918
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of GFI1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of GFI1 mRNA	16888099
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of GFI1 mRNA	29024780
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GFI1 gene	25560391
D014750	Vincristine	Vincristine results in decreased expression of GFI1 mRNA	23649840
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of GFI1 mRNA	17330099

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	19506020
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	11060035 12874834 16287849 17197705 17636019 17909014 18805794 19506020 20190815 20547752 21570500
GO:0044212	transcription regulatory region DNA binding	-	IBA	21873635
GO:0044212	transcription regulatory region DNA binding	-	IDA	15947108
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	8441411
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	15947108 19506020
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	-	IDA	15947108
GO:0010957	negative regulation of vitamin D biosynthetic process	-	IC	15947108
GO:0010977	negative regulation of neuron projection development	-	IDA	19026687
GO:0016032	viral process	-	TAS	8441411
GO:0030097	hemopoiesis	-	IEA	-
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	ISS	-
GO:0034121	regulation of toll-like receptor signaling pathway	-	IDA	20547752
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	12874834
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0051569	regulation of histone H3-K4 methylation	-	IEA	-
GO:0070105	positive regulation of interleukin-6-mediated signaling pathway	-	IDA	11060035
GO:0071222	cellular response to lipopolysaccharide	-	IEP	20547752

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	12874834 20547752
GO:0005654	nucleoplasm	-	IBA	21873635
GO:0016363	nuclear matrix	-	IDA	12874834
GO:0016604	nuclear body	-	IDA	11060035
GO:0017053	transcriptional repressor complex	-	IDA	12874834 19506020

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25862628	DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)	Kupers LK	Int J Epidemiol
28820654	Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy. (2017)	van Otterdijk SD	Epigenetics
25325234	Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age. (2015 Feb)	Lee KW	Environ Health Perspect
28494218	Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife. (2018)	Tehranifar P	Epigenetics
27403598	Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. (2016 Sep)	Gonseth S	Epigenetics
25552657	Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). (2015 Apr 15)	Richmond RC	Hum Mol Genet
22851337	450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. (2012 Oct)	Joubert BR	Environ Health Perspect
24485148	Differences in smoking associated DNA methylation patterns in South Asians and Europeans. (2014 Feb 3)	Elliott HR	Clin Epigenetics
28662467	Locus-specific DNA methylation changes and phenotypic variability in children with attention-deficit hyperactivity disorder. (2017 Oct)	Sengupta SM	Psychiatry Res
27677632	Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. (2016 Dec)	Schwender K	Forensic Sci Med Pathol
29618728	Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)	Miyake K	Sci Rep
29695247	Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. (2018 Apr 25)	Witt SH	BMC Genomics
26580635	Assessment of Offspring DNA Methylation across the Lifecourse Associated with Prenatal Maternal Smoking Using Bayesian Mixture Modelling. (2015 Nov 13)	de Vocht F	Int J Environ Res Public Health