Gene: GFI1

2672
GFI-1|GFI1A|SCN2|ZNF163
growth factor independent 1 transcriptional repressor
protein-coding
1p22.1
Ensembl:ENSG00000162676 MIM:600871 Vega:OTTHUMG00000010897 UniprotKB:Q99684
NG_007874.1
PubMed
ND
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.472e-1 (AD)  3.378e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09935388chr1:92947588GFI12.310e-84Maternal smoking in pregnancy27040690
cg14179389chr1:92947961GFI16.260e-68Maternal smoking in pregnancy27040690
cg12876356chr1:92946825GFI12.310e-71Maternal smoking in pregnancy27040690
cg18146737chr1:92946700GFI11.790e-63Maternal smoking in pregnancy27040690
cg09662411chr1:92946132GFI16.690e-52Maternal smoking in pregnancy27040690
cg18316974chr1:92947035GFI11.050e-53Maternal smoking in pregnancy27040690
cg06338710chr1:92946187GFI18.790e-41Maternal smoking in pregnancy27040690
cg10399789chr1:92945668GFI12.070e-29Maternal smoking in pregnancy27040690
cg04535902chr1:92947332GFI12.150e-18Maternal smoking in pregnancy27040690
cg09935388chr1:92947588GFI16.610e-111Maternal smoking in pregnancy27040690
cg14179389chr1:92947961GFI12.790e-101Maternal smoking in pregnancy27040690
cg12876356chr1:92946825GFI18.350e-99Maternal smoking in pregnancy27040690
cg18146737chr1:92946700GFI16.140e-91Maternal smoking in pregnancy27040690
cg09662411chr1:92946132GFI16.350e-76Maternal smoking in pregnancy27040690
cg18316974chr1:92947035GFI11.470e-67Maternal smoking in pregnancy27040690
cg06338710chr1:92946187GFI15.560e-49Maternal smoking in pregnancy27040690
cg10399789chr1:92945668GFI11.170e-34Maternal smoking in pregnancy27040690
cg04535902chr1:92947332GFI11.390e-22Maternal smoking in pregnancy27040690
cg09935388chr1:92947588GFI12.290e-119Maternal smoking in pregnancy27040690
cg14179389chr1:92947961GFI12.780e-107Maternal smoking in pregnancy27040690
cg12876356chr1:92946825GFI19.280e-108Maternal smoking in pregnancy27040690
cg18146737chr1:92946700GFI12.580e-100Maternal smoking in pregnancy27040690
cg09662411chr1:92946132GFI14.960e-85Maternal smoking in pregnancy27040690
cg18316974chr1:92947035GFI18.760e-74Maternal smoking in pregnancy27040690
cg06338710chr1:92946187GFI15.540e-56Maternal smoking in pregnancy27040690
cg10399789chr1:92945668GFI11.000e-47Maternal smoking in pregnancy27040690
cg04535902chr1:92947332GFI15.820e-22Maternal smoking in pregnancy27040690
cg04955573chr1:92944306GFI13.210e-14Maternal smoking in pregnancy27040690
cg14179389chr1:92947961GFI15.460e-16Maternal smoking in pregnancy27040690
cg09935388chr1:92947588GFI13.100e-17Smoking27651444
cg09662411chr1:92946132GFI12.200e-16Smoking27651444
cg12876356chr1:92946825GFI11.500e-15Smoking27651444
cg18146737chr1:92946700GFI14.800e-15Smoking27651444
cg18316974chr1:92947035GFI15.200e-14Smoking27651444
cg06338710chr1:92946187GFI11.700e-12Smoking27651444
cg14179389chr1:92947961GFI11.700e-9Smoking27651444
cg10399789chr1:92945668GFI17.100e-9Smoking27651444
cg09935388chr1:92947588GFI12.070e-17Alcohol consumption per day27843151
cg12876356chr1:92946825GFI15.860e-13Alcohol consumption per day27843151
cg18146737chr1:92946700GFI11.530e-9Alcohol consumption per day27843151
cg18316974chr1:92947035GFI11.900e-9Alcohol consumption per day27843151
cg09935388chr1:92947588GFI18.360e-26Tobacco smoking28225026
cg12876356chr1:92946825GFI12.090e-14Tobacco smoking28225026
cg18146737chr1:92946700GFI13.230e-11Tobacco smoking28225026
cg18316974chr1:92947035GFI15.150e-11Tobacco smoking28225026
cg09662411chr1:92946132GFI13.170e-8Tobacco smoking28225026
cg09935388chr1:92947588GFI18.640e-48Smoking28686328
cg12876356chr1:92946825GFI17.500e-35Smoking28686328
cg18316974chr1:92947035GFI11.070e-32Smoking28686328
cg09662411chr1:92946132GFI14.300e-28Smoking28686328
cg18146737chr1:92946700GFI13.100e-26Smoking28686328
cg06338710chr1:92946187GFI11.870e-23Smoking28686328
cg04535902chr1:92947332GFI11.030e-21Smoking28686328
cg10399789chr1:92945668GFI17.990e-19Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCRL30.718
IL2RB0.695
SLAMF70.688
TBX210.684
PARP150.678
KIR2DS40.673
DCAF4L20.661
LCK0.656
PRF10.655
OR4D110.651

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.345
OMG-0.321
B3GALT1-0.305
ZNF835-0.304
FUT9-0.301
PURG-0.298
LGI1-0.294
GGH-0.286
CRYBA2-0.285
C19orf73-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of GFI1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GFI1 gene27153756
C430898AGN 194204AGN 194204 results in increased expression of GFI1 mRNA16339527
D000447AldehydesAldehydes results in increased expression of GFI1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GFI1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GFI1 mRNA24449571
D001151ArsenicArsenic affects the methylation of GFI1 gene25304211
D001280AtrazineAtrazine results in increased expression of GFI1 mRNA25929836
D001554BenzeneBenzene results in increased expression of GFI1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of GFI1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GFI1 mRNA22316170|2623829
C006780bisphenol Abisphenol A results in decreased expression of GFI1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of GFI1 mRNA17553608
C018475butyraldehydebutyraldehyde results in increased expression of GFI1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GFI1 mRNA24982889
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of GFI1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFI1 gene20938992
D003367CotinineCotinine affects the methylation of GFI1 gene22851337
D003520CyclophosphamideCyclophosphamide results in decreased expression of GFI1 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of GFI1 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GFI1 mRNA23914054
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of GFI1 mRNA17330099
D003907DexamethasoneDexamethasone results in decreased expression of GFI1 mRNA21041162
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of GFI1 mRNA28962523
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of GFI1 mRNA21041162
D005038EthylnitrosoureaEthylnitrosourea results in decreased expression of GFI1 protein28549617
D005419FlavonoidsFlavonoids results in increased expression of GFI1 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFI1 gene20938992
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GFI1 mRNA25982114
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GFI1 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of GFI1 mRNA17400583
D009532NickelNickel results in increased expression of GFI1 mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GFI1 mRNA25729387
C046012pentanalpentanal results in increased expression of GFI1 mRNA26079696
C467566pomalidomidepomalidomide results in increased expression of GFI1 mRNA15292067
D011374ProgesteroneProgesterone results in increased expression of GFI1 mRNA21768398
D011374ProgesteroneTGFB1 protein promotes the reaction [Progesterone results in increased expression of GFI1 mRNA]21768398
C005556propionaldehydepropionaldehyde results in increased expression of GFI1 mRNA26079696
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GFI1 mRNA19073995
D013629TamoxifenTamoxifen results in increased expression of GFI1 mRNA19031437
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GFI1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GFI1 mRNA16102516|2104116
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of GFI1 mRNA16888099
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of GFI1 gene26756918
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GFI1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GFI1 mRNA16888099
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GFI1 mRNA29024780
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GFI1 gene25560391
D014750VincristineVincristine results in decreased expression of GFI1 mRNA23649840
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of GFI1 mRNA17330099

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA19506020  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI11060035  12874834  16287849  17197705  17636019  17909014  
18805794  19506020  20190815  20547752  21570500  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA15947108  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS8441411  
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15947108  19506020  
GO:0006351transcription, DNA-templated-IEA-  
GO:0010956negative regulation of calcidiol 1-monooxygenase activity-IDA15947108  
GO:0010957negative regulation of vitamin D biosynthetic process-IC15947108  
GO:0010977negative regulation of neuron projection development-IDA19026687  
GO:0016032viral process-TAS8441411  
GO:0030097hemopoiesis-IEA-  
GO:0032088negative regulation of NF-kappaB transcription factor activity-ISS-  
GO:0034121regulation of toll-like receptor signaling pathway-IDA20547752  
GO:0045892negative regulation of transcription, DNA-templated-IDA12874834  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0051569regulation of histone H3-K4 methylation-IEA-  
GO:0070105positive regulation of interleukin-6-mediated signaling pathway-IDA11060035  
GO:0071222cellular response to lipopolysaccharide-IEP20547752  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12874834  20547752  
GO:0005654nucleoplasm-IBA21873635  
GO:0016363nuclear matrix-IDA12874834  
GO:0016604nuclear body-IDA11060035  
GO:0017053transcriptional repressor complex-IDA12874834  19506020  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25862628DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)Kupers LKInt J Epidemiol
28820654Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy. (2017)van Otterdijk SDEpigenetics
25325234Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age. (2015 Feb)Lee KWEnviron Health Perspect
28494218Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife. (2018)Tehranifar PEpigenetics
27403598Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. (2016 Sep)Gonseth SEpigenetics
25552657Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). (2015 Apr 15)Richmond RCHum Mol Genet
22851337450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. (2012 Oct)Joubert BREnviron Health Perspect
24485148Differences in smoking associated DNA methylation patterns in South Asians and Europeans. (2014 Feb 3)Elliott HRClin Epigenetics
28662467Locus-specific DNA methylation changes and phenotypic variability in children with attention-deficit hyperactivity disorder. (2017 Oct)Sengupta SMPsychiatry Res
27677632Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. (2016 Dec)Schwender KForensic Sci Med Pathol
29618728Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)Miyake KSci Rep
29695247Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. (2018 Apr 25)Witt SHBMC Genomics
26580635Assessment of Offspring DNA Methylation across the Lifecourse Associated with Prenatal Maternal Smoking Using Bayesian Mixture Modelling. (2015 Nov 13)de Vocht FInt J Environ Res Public Health