Gene: GFRA1

2674
GDNFR|GDNFRA|GFR-ALPHA-1|RET1L|RETL1|TRNR1
GDNF family receptor alpha 1
protein-coding
10q25.3
Ensembl:ENSG00000151892 MIM:601496 Vega:OTTHUMG00000019097 UniprotKB:P56159
NG_050620.1
PubMed
ND
1   
6.286e-1 (AD)  6.739e-1 (ND)   (Frontal_Cortex)
5.551e-1 (AD)  4.149e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPD20.718
SPON10.71
UNG0.698
DHTKD10.697
DPY19L30.695
NTRK20.691
WLS0.688
PBXIP10.687
ACOX10.687
SLC44A20.686

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.392
OR4F29-0.353
PNOC-0.343
EGFL6-0.332
VTCN1-0.329
FREM3-0.318
SCN5A-0.313
HCRTR1-0.311
NPBWR1-0.311
PIK3C2G-0.311

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased expression of GFRA1 mRNA"25270620
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GFRA1 mRNA"28903501
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of GFRA1 mRNA"21920950
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GFRA1 mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GFRA1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GFRA1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GFRA1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GFRA1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of GFRA1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GFRA1 mRNA19770486
D000447AldehydesAldehydes results in increased expression of GFRA1 mRNA25014914
D000452Aldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
D000452AldrinAldrin results in decreased expression of GFRA1 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GFRA1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GFRA1 mRNA24449571
D001151ArsenicArsenic affects the expression of GFRA1 protein24675094
D001151ArsenicArsenic affects the methylation of GFRA1 gene25304211
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in increased expression of GFRA1 mRNA16443354
D001280AtrazineAtrazine results in decreased expression of GFRA1 mRNA25929836
C487081belinostatbelinostat results in decreased expression of GFRA1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GFRA1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GFRA1 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GFRA1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of GFRA1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of GFRA1 mRNA16474171|1916744
C006780bisphenol Abisphenol A results in increased expression of GFRA1 mRNA16474171
C006780bisphenol Abisphenol A affects the methylation of GFRA1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of GFRA1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GFRA1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of GFRA1 mRNA26079696
D002211CapsaicinCapsaicin affects the expression of GFRA1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
D002220CarbamazepineCarbamazepine affects the expression of GFRA1 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of GFRA1 mRNA26272509
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GFRA1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of GFRA1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of GFRA1 mRNA19167446
D003520CyclophosphamideGFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D016572CyclosporineCyclosporine results in decreased expression of GFRA1 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of GFRA1 mRNA21865292
D003634DDT[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
D003907DexamethasoneDexamethasone results in increased expression of GFRA1 mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of GFRA1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of GFRA1 mRNA]20032058
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GFRA1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GFRA1 mRNA21151649
D003632Dichlorodiphenyldichloroethane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
D003633Dichlorodiphenyl Dichloroethylene[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
D004026Dieldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
D004317DoxorubicinGFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D004732Endrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
C118739entinostatentinostat results in decreased expression of GFRA1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
D000431EthanolEthanol results in decreased expression of GFRA1 mRNA22198099
D000431EthanolEthanol results in decreased expression of GFRA1 mRNA15353170
D005472FluorouracilGFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C039281furanfuran results in decreased expression of GFRA1 mRNA25539665
D019833GenisteinGenistein results in increased expression of GFRA1 mRNA16474171
D006025GlycosaminoglycansGlycosaminoglycans affects the reaction [GDNF protein promotes the reaction [GFRA1 protein results in increased activity of RET protein]]20807638
D017313FenretinideFenretinide results in increased expression of GFRA1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GFRA1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GFRA1 mRNA27392435
D007657Ketone BodiesKetone Bodies results in decreased expression of GFRA1 mRNA16807920
D001556Lindane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
D008701MethapyrileneMethapyrilene results in decreased expression of GFRA1 mRNA16393664
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GFRA1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GFRA1 mRNA"26251327
C568376MT19c compoundMT19c compound results in decreased expression of GFRA1 mRNA21781307
C500085muraglitazarmuraglitazar results in decreased expression of GFRA1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GFRA1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GFRA1 mRNA"25620056
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
D009532NickelNickel results in decreased expression of GFRA1 mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GFRA1 mRNA27935865
D017239PaclitaxelGFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C016030pantogabpantogab results in increased expression of GFRA1 mRNA17379144
D010269ParaquatParaquat results in increased expression of GFRA1 mRNA17077588
C046012pentanalpentanal results in increased expression of GFRA1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of GFRA1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GFRA1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GFRA1 mRNA19429403
D010615PhenacetinPhenacetin results in increased expression of GFRA1 mRNA17698508
D010634PhenobarbitalPhenobarbital results in increased expression of GFRA1 mRNA19270015
C030299phenylhydrazinephenylhydrazine results in increased expression of GFRA1 mRNA17698508
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GFRA1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GFRA1 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GFRA1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GFRA1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GFRA1 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in increased expression of GFRA1 mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of GFRA1 mRNA19162173
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of GFRA1 mRNA16474171
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of GFRA1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GFRA1 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of GFRA1 mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of GFRA1 mRNA19167446
C089730rosiglitazonerosiglitazone results in decreased expression of GFRA1 mRNA21515302
D012402RotenoneRotenone results in decreased expression of GFRA1 mRNA19013527
D012834SilverSilver results in increased expression of GFRA1 mRNA27131904
D019821Simvastatin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA28263720
C009277sodium arsenatesodium arsenate results in increased expression of GFRA1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of GFRA1 mRNA22714537
D012969Sodium FluorideSodium Fluoride results in increased expression of GFRA1 mRNA27862939
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]22150557
C446685systhanesysthane results in decreased expression of GFRA1 mRNA16730040
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA"18579281
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of GFRA1 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GFRA1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GFRA1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GFRA1 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GFRA1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of GFRA1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of GFRA1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNA19770486|2323856
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GFRA1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNA23238561
D013853ThioacetamideThioacetamide results in decreased expression of GFRA1 mRNA23411599
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in increased expression of GFRA1 mRNA16443354
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GFRA1 mRNA17085092
D014212TretinoinTretinoin results in increased expression of GFRA1 mRNA16604517
D014212TretinoinTretinoin results in decreased expression of GFRA1 mRNA17303670
C032910triadimefontriadimefon results in decreased expression of GFRA1 mRNA16730040
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GFRA1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of GFRA1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GFRA1 mRNA"24407104
C057693troglitazonetroglitazone results in decreased expression of GFRA1 mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GFRA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GFRA1 mRNA25192806|2800136
D014635Valproic AcidValproic Acid results in increased expression of GFRA1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of GFRA1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GFRA1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of GFRA1 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFRA1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of GFRA1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-TAS9545641  
GO:0016167glial cell-derived neurotrophic factor receptor activity-TAS10829012  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007165signal transduction-IBA21873635  
GO:0007166cell surface receptor signaling pathway-NAS8674117  
GO:0007399nervous system development-IBA21873635  
GO:0007411axon guidance-TAS-  
GO:0035860glial cell-derived neurotrophic factor receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0019898extrinsic component of membrane-TAS10829012  
GO:0031225anchored component of membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-8853659RET signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24641868Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens. (2014 May)Evans RLCancer Prev Res (Phila)